Plasticidad de las redes neuronales

Líneas de investigación

¿Cómo codifica, almacena y recupera nuestro cerebro las memorias?
Las experiencias modulan la actividad sináptica en el cerebro y determinan su estructura funcional. De esta forma, las redes neuronales relevantes en un determinado contexto son reclutadas y garantizan la adaptación comportamental. No obstante y a pesar de su importancia, conocemos muy poco sobre las reglas que rigen la transformación de la dinámica sináptica en dinámica de la red neuronal. Trabajos de nuestro laboratorio han demostrado que los circuitos neuronales que soportan el aprendizaje y la memoria son funcionalmente reorganizados como consecuencia de la potenciación sináptica en el hipocampo. En la actualidad estamos investigando los mecanismos que subyacen a dicha reorganización funcional, centrándonos en fenómenos de plasticidad sináptica a corto y largo plazo, así como en el balance excitación/inhibición en regiones concretas del cerebro. Con ello, además, investigamos los mecanismos que determinan la direccionalidad del flujo de información en el complejo entramado de conexiones cerebrales. Empleamos diversos modelos animales y técnicas de imagen por resonancia magnética funcional (RMNf) combinadas con registros electrofisiológicos, estimulación eléctrica u optogenética de regiones diana y evaluación comportamental.

Los mismos mecanismos celulares que median la neuroplasticidad y permiten aprender de, y reaccionar ante, cambios en el ambiente, también pueden ser activados por drogas de abuso. Estudios en humanos y animales han demostrado que la naturaleza refractaria de la adicción resulta de la activación, inducida por la droga, de los circuitos de recompensa. De esta forma, los comportamientos de búsqueda de droga son aprendidos y quedan grabados en el cerebro de los adictos. Aplicando la misma aproximación experimental multidisciplinar, estamos investigando la reorganización funcional de las redes neuronales que sostienen la adicción y la recaída.

Publicaciones relevantes

Mapping microglia and astrocyte activation in vivo using diffusion MRI Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena , Mark Drakesmith2, Kristin Koller, Derek K Jones , Santiago Canals , Silvia De Santis Sci Adv. 2022 8(21):eabq2923 https://doi.org/10.1126/sciadv.abq2923
Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks López-Madrona VJ, Pérez-Montoyo E, Álvarez-Salvado E, Moratal D, Herreras O, Pereda E, Mirasso CR, Canals S eLife 2020 9:e57313 https://doi.org/10.7554/eLife.57313
KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain Lipinski M, Muñoz-Viana R, Del Blanco B, Marquez-Galera A, Medrano-Relinque J, Caramés JM, Szczepankiewicz AA, Fernandez-Albert J, Navarrón CM, Olivares R, Wilczyński GM, Canals S, Lopez-Atalaya JP, Barco A Nat Commun 2020 11(1):2588 https://doi.org/10.1038/s41467-020-16246-0
Multishell diffusion imaging reveals sex-specific trajectories of early white matter degeneration in normal aging Toschi N, Gisbert RA, Passamonti L, Canals S, De Santis S Neurobiol Aging 2020 86:191 https://doi.org/10.1016/j.neurobiolaging.2019.11.014
Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence De Santis S, Bach P, Pérez-Cervera L, Cosa-Linan A, Weil G, Vollstädt-Klein S, Hermann D, Kiefer F, Kirsch P, Ciccocioppo R, Sommer WH, Canals S JAMA Psychiatry 2019 76(7):749 https://doi.org/10.1001/jamapsychiatry.2019.0318
Finding influential nodes for integration in brain networks using optimal percolation theory Del Ferraro G, Moreno A, Min B, Morone F, Perez-Ramirez U, Peérez-Cervera L, Parra LC, Holodny A, Canals S, Makse HA Nat Commun 2018 9(1):2274 https://doi.org/10.1038/s41467-018-04718
Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features Aller MI, Pecoraro V, Paternain AV, Canals S, Lerma J J Neurosci 2015 35(40):13619 https://doi.org/10.1523/JNEUROSCI.2217-15.2015
Functional MRI of long-term potentiation: imaging network plasticity Alvarez-Salvado E, Pallares V, Moreno A, Canals S Philos Trans R Soc B-Biol Sci 2014 369 (1633) https://doi.org/10.1098/rstb.2013.0152

Investigador principal

Santiago Canals Gamoneda

Investigador doctor

Encarni Marcos Sanmartín

Investigador doctor

Alejandro Sempere Ferrández

Predoctoral / Apoyo investigación

Raquel García Hernández

Predoctoral / Apoyo investigación

Jesús Limens Pinaque

Predoctoral / Apoyo investigación

Elena Pérez Montoyo

Predoctoral / Apoyo investigación

Andrés Pérez Segura

Predoctoral / Apoyo investigación

Predoctoral / Apoyo investigación

Alejandro Trouvé Carpena

Técnico

Analía Rico Rodríguez

Técnico

Clara Serrano Navarro

Administración

Rosa Sánchez Cayuela

Estudiantes máster

Alejandro Sospedra Orellano

Mapping microglia and astrocyte activation in vivo using diffusion MRI Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena , Mark Drakesmith2, Kristin Koller, Derek K Jones , Santiago Canals , Silvia De Santis Sci Adv. 2022 8(21):eabq2923 https://doi.org/10.1126/sciadv.abq2923
From a systems view to spotting a hidden island: A narrative review implicating insula function in alcoholism Sommer WH, Canals S, Bifone A, Heilig M, Hyytiä P Neuropharmacology 2022 209:108989 https://doi.org/10.1016/j.neuropharm.2022.108989
Increased network centrality of the anterior insula in early abstinence from alcohol Bordier C, Weil G, Bach P, Scuppa G, Nicolini C, Forcellini G, Pérez-Ramirez U, Moratal D, Canals S, Hoffmann S, Hermann D, Vollstädt-Klein S, Kiefer F, Kirsch P, Sommer WH, Bifone A Addict Biol 2022 27(1):e13096 https://doi.org/10.1111/adb.13096
Functional Interactions between Entorhinal Cortical Pathways Modulate Theta Activity in the Hippocampus Lopez-Madrona VJ, Canals S Biology (Basel) 2021 10(8):692 https://doi.org/10.3390/biology10080692
Increased network centrality of the anterior insula in early abstinence from alcohol Bordier C, Weil G, Bach P, Scuppa G, Nicolini C, Forcellini G, Pérez-Ramirez U, Moratal D, Canals S, Hoffmann S, Hermann D, Vollstädt-Klein S, Kiefer F, Kirsch P, Sommer WH, Bifone A Addict Biol 2021 27(1):e13096 https://doi.org/10.1111/adb.13096
Information Transmission in Delay-Coupled Neuronal Circuits in the Presence of a Relay Population Sánchez-Claros J, Pariz A, Valizadeh A, Canals S, Mirasso CR Front Syst Neurosci 2021 15:705371 https://doi.org/10.3389/fnsys.2021.705371
Natural Polyhydroxy Flavonoids, Curcuminoids, and Synthetic Curcumin Analogs as a7 nAChRs Positive Allosteric Modulators Ximenis M, Mulet J, Sala S, Sala F, Criado M, González-Muñiz R, Pérez de Vega MJ Int J Mol Sci 2021 22(2):973 https://doi.org/10.3390/ijms22020973
Neuroimaging reveals functionally distinct neuronal networks associated with high-level alcohol consumption in two genetic rat models Pallarés V, Dudek M, Moreno A, Pérez-Ramírez Ú, Moratal D, Haaranen M, Ciccocioppo R, Sommer WH, Canals S, Hyytiä P Behav Pharmacol 2021 32(2&3):229 https://doi.org/10.1097/FBP.0000000000000582
The importance of urgency in decision making based on dynamic information Ferrucci L, Genovesio A, Marcos E PLoS Comput Biol 2021 17(10):e1009455 https://doi.org/10.1371/journal.pcbi.1009455
Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain De Santis S, Cosa-Linan A, Garcia-Hernandez R, Dmytrenko L, Vargova L, Vorisek I, Stopponi S, Bach P, Kirsch P, Kiefer F, Ciccocioppo R, Sykova E, Moratal D, Sommer WH, Canals S Sci Adv 2020 6(26):eaba0154 https://doi.org/10.1126/sciadv.aba0154
Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks López-Madrona VJ, Pérez-Montoyo E, Álvarez-Salvado E, Moratal D, Herreras O, Pereda E, Mirasso CR, Canals S eLife 2020 9:e57313 https://doi.org/10.7554/eLife.57313
Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone Bach P, Weil G, Pompili E, Hoffmann S, Hermann D, Vollstädt-Klein S, Mann K, Perez-Ramirez U, Moratal D, Canals S, Dursun SM, Greenshaw AJ, Kirsch P, Kiefer F, Sommer WH Addict Biol 2020 25(1):e12717 https://doi.org/10.1111/adb.12717
KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain Lipinski M, Muñoz-Viana R, Del Blanco B, Marquez-Galera A, Medrano-Relinque J, Caramés JM, Szczepankiewicz AA, Fernandez-Albert J, Navarrón CM, Olivares R, Wilczyński GM, Canals S, Lopez-Atalaya JP, Barco A Nat Commun 2020 11(1):2588 https://doi.org/10.1038/s41467-020-16246-0
Low-dimensional dynamics for working memory and time encoding Cueva CJ, Saez A, Marcos E, Genovesio A, Jazayeri M, Romo R, Salzman CD, Shadlen MN, Fusi S Proc Natl Acad Sci USA 2020 117(37):23021 https://doi.org/10.1073/pnas.1915984117
Multishell diffusion imaging reveals sex-specific trajectories of early white matter degeneration in normal aging Toschi N, Gisbert RA, Passamonti L, Canals S, De Santis S Neurobiol Aging 2020 86:191 https://doi.org/10.1016/j.neurobiolaging.2019.11.014
1-(2 ‘,5 ‘-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of alpha 7 Nicotinic Receptors with Analgesic and Neuroprotective Activity Perez de Vega MJ, Fernandez-Mendivil C, de la Torre-Martinez R, Gonzalez-Rodriguez S, Mullet J, Sala F, Sala S, Criado M, Moreno-Fernandez S, Miguel M, Fernandez-Carvajal A, Ferrer-Montiel A, Lopez MG, Gonzalez-Muniz R ACS Chem Neurosci 2019 10(8):3900 https://doi.org/10.1021/acschemneuro.9b00364
Detecting Alcohol-Induced Brain Damage Noninvasively Using Diffusion Tensor Imaging De Santis S, Sommer WHx Canals S ACS Chem Neurosci 2019 10(10):4187 https://doi.org/10.1021/acschemneuro.9b00481
Direct pathway neurons in mouse dorsolateral striatum in vivo receive stronger synaptic input than indirect pathway neurons Filipović M, Ketzef M, Reig R, Aertsen A, Silberberg G, Kumar A Journal of Neurophysiology 2019 122(6):2294 https://doi.org/10.1152/jn.00481.2019
Hidden Markov Models Predict the Future Choice Better Than a PSTH-Based Method Marcos E, Londei F, Genovesio A Neural Computation 2019 31(9):1874 https://doi.org/10.1162/neco_a_01216
Inferring correlations associated to causal interactions in brain signals using autoregressive models López-Madrona VJ, Matias FS, Mirasso CR, Canals S, Pereda E Scientifc Reports 2019 9(1):17041 https://doi.org/10.1038/s41598-019-53453-2
Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence De Santis S, Bach P, Pérez-Cervera L, Cosa-Linan A, Weil G, Vollstädt-Klein S, Hermann D, Kiefer F, Kirsch P, Ciccocioppo R, Sommer WH, Canals S JAMA Psychiatry 2019 76(7):749 https://doi.org/10.1001/jamapsychiatry.2019.0318
Non-invasive MRI windows to neuroinflammation De Santis S, Canals S Neuroscience 2019 403:1 https://doi.org/10.1016/j.neuroscience.2019.01.051
Radiomicrobiomics: Advancing Along the Gut-brain Axis Through Big Data Analysis De Santis S, Moratal D, Canals S Magn Reson Imaging 2019 403:145 https://doi.org/10.1016/j.neuroscience.2017.11.055
TherMouseDuino: An affordable Open-Source temperature control system for functional magnetic resonance imaging experimentation with mice Quiñones DR, Fernandez-Molla LM, Pacheco-Torres J, Carames JM, Canals S, Moratal D Magn Reson Imaging 2019 58:67 https://doi.org/10.1016/j.mri.2019.01.009
A Tangible Educative 3D Printed Atlas of the Rat Brain Quiñones DR, Ferragud-Agullo J, Perez-Feito R, Garcia-Manrique JA, Canals S, Moratal D Materials 2018 11(9):1531 https://doi.org/10.3390/ma11091531
Alcoholic liver disease: Utility of animal models Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gomez Del Moral M, Martinez-Naves E, Nevzorova YA, Cubero FJ World J Gastroenterol 2018 24(45):5063 https://doi.org/10.3748/wjg.v24.i45.5063
Finding influential nodes for integration in brain networks using optimal percolation theory Del Ferraro G, Moreno A, Min B, Morone F, Perez-Ramirez U, Peérez-Cervera L, Parra LC, Holodny A, Canals S, Makse HA Nat Commun 2018 9(1):2274 https://doi.org/10.1038/s41467-018-04718
Functional MRI of Synaptic Plasticity Pacheco-Torres, Jesus; Moreno, Andrea; Fernandez, Begona; Perez-Cervera, Laura; Maria Carames, Jose; Miguel Fernandez-Molla, Luis; Perez-Montoyo, Elena; Martinez-Sanchez, Miriam; Moratal, David; Canals, Santiago HANDBOOK OF IN VIVO NEURAL PLASTICITY TECHNIQUES: A SYSTEMS NEUROSCIENCE APPROACH TO THE NEURAL BASIS OF MEMORY AND COGNITION 2018 28:441 https://doi.org/10.1016/B978-0-12-812028-6.00024-0
High frequency neurons determine effective connectivity in neuronal networks Pariz A, Esfahani ZG, Parsi SS, Valizadeh A, Canals S, Mirasso CR Neuroimage 2018 166:349 https://doi.org/10.1016/j.neuroimage.2017.11.014
Mapping Functional Connectivity in the Rodent Brain Using Electric-Stimulation fMRI Perez-Cervera L, Carames JM, Fernandez-Molla LM, Moreno A, Fernandez B, Perez-Montoyo E, Moratal D, Canals S, Pacheco-Torres J Methods Mol Biol 2018 1718:117 https://doi.org/10.1007/978-1-4939-7531-0_8
Silent Learning Rossato JI, Moreno A, Genzel L, Yamasaki M, Takeuchi T, Canals S, Morris RGM Curr Biol 2018 28(21):3508 https://doi.org/10.1016/j.cub.2018.09.012
Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study Lucia FS, Pacheco-Torres J, González-Granero S, Canals S, Obregón MJ, García-Verdugo JM, Berbel P Front Neuroanat 2018 12:31 https://doi.org/10.3389/fnana.2018.00031
Multi-modal MRI classifiers identify excessive alcohol consumption and treatment effects in the brain Cosa A, Moreno A, Pacheco-Torres J, Ciccocioppo R, Hyytiä P, Sommer WH, Moratal D, Canals S Addict Biol 2017 22(5):1459 https://doi.org/10.1111/adb.12418
On the role of the entorhinal cortex in the effective connectivity of the hippocampal formation Lopez-Madrona VJ, Matias FS, Pereda E, Canals S, Mirasso CR Chaos 2017 27(4):47401 https://doi.org/10.1063/1.4979001
The Yin and Yang of Memory Consolidation: Hippocampal and Neocortical Genzel , Rossato JI, Jacobse J, Grieves RM, Spooner PA, Battaglia FP, Fernandez G, Morris RGM Plos Biol 2017 15(1):e200531 https://doi.org/10.1371/journal.pbio.2000531
1,3-diphenylpropan-1-ones as allosteric modulators of alpha 7 nACh receptors with analgesic and antioxidant properties Criado M, Balsera B, Mulet J, Sala S, Sala F, de la Torre-Martinez R, Fernandez-Carvajal A, Ferrer-Montiel A, Moreno-Fernandez S, Miguel M, Perez de Vega MJ, Gonzalez-Muñiz R Future Med Chem 2016 8(7):731 https://doi.org/10.4155/fmc-2015-0001
Frequency-Dependent Gating of Hippocampal-Neocortical Interactions Moreno A, Morris RGM, Canals S Cereb Cortex 2016 26(5):2105 https://doi.org/10.1093/cercor/bhv033
Modulation of nucleus accumbens connectivity by alcohol drinking and naltrexone in alcohol-preferring rats: A manganese-enhanced magnetic resonance imaging study Dudek M, Canals S, Sommer WH, Hyytiä P Eur Neuropsychopharmacol 2016 26(3):445 https://doi.org/10.1016/j.euroneuro.2016.01.003
N-Benzylpiperidine Derivatives as alpha 7 Nicotinic Receptor Antagonists Criado M, Mulet J, Sala F, Sala S, Colmena I, Gandia L, Bautista-Aguilera OM, Samadi A, Chioua M, Marco-Contelles J ACS Chem Neurosci 2016 7(8):1157 https://doi.org/10.1021/acschemneuro.6b00122
Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens Hadar R, Vengeliene V, Barroeta Hlusicke E, Canals S, Noori HR, Wieske F, Rummel J, Harnack D, Heinz A, Spanagel R, Winter C Transl Psychiatr 2016 6:e840 https://doi.org/10.1038/tp.2016.100
Tuning noninvasive brain stimulation with MRI to cope with intersubject variability Habich A, Canals S, Klöppel S Curr Opin Neurol 2016 29(4):453 https://doi.org/10.1097/WCO.0000000000000353
Adult Newborn Neurons Are Involved in Learning Acquisition and Long-Term Memory Formation: The Distinct Demands on Temporal Neurogenesis of Different Cognitive Tasks Suarez-Pereira I, Canals S, Carrion AM Hippocampus 2015 25(1):51 https://doi.org/10.1002/hipo.22349
Brain activation induced by voluntary alcohol and saccharin drinking in rats assessed with manganese-enhanced magnetic resonance imaging Dudek M, Abo-Ramadan U, Hermann D, Brown M, Canals S, Sommer WH, Hyytia P Addict Biol 2015 20(6):1012 https://doi.org/10.1111/adb.12179
Brain size regulations by cbp haploinsufficiency evaluated by in-vivo MRI based volumetry Ateca-Cabarga JC, Cosa A, Pallares V, Lopez-Atalaya JP, Barco A, Canals S, Moratal D Sci Rep 2015 5:16256 https://doi.org/10.1038/srep16256
Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features Aller MI, Pecoraro V, Paternain AV, Canals S, Lerma J J Neurosci 2015 35(40):13619 https://doi.org/10.1523/JNEUROSCI.2217-15.2015
Neurosurgery planning in rodents using a magnetic resonance imaging assisted framework to target experimentally defined networks Pallares V, Moya J, Samper-Belda FJ, Canals S, Moratal D Comput Meth Programs Biomed 2015 121(2):66 https://doi.org/10.1016/j.cmpb.7015.05.011
Widespread Vestibular Activation of the Rodent Cortex Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW J Neurosci 2015 35(15):5926 https://doi.org/10.1523/JNEUROSCI.1869-14.2015
Avoiding catastrophic failure in correlated networks of networks Reis S, Hu Y, Babino A, Andrade JA, Canals S, Sigman M, Makse H Nat Phys 2014 10(10):762 https://doi.org/10.1038/NPHYS3081
Chalcones as positive allosteric modulators of alpha-7 nicotinic acetylcholine receptors: A new target for a privileged structure Balsera B, Mulet J, Fernandez-Carvajal A, Torre-Martinez Rde L, Ferrer-Montiel A, Hernandez-Jimenez JG, Estevez-Her, Borges R, Freitas AE, Lopez MG, Garcia-Lopez MT, Gonzalez-Muñiz R, Perez de Vega MJ, Valor LM, Svobodova L, Sala S, Sala F, Criado M Eur J Med Chem 2014 86:724 https://doi.org/10.1016/j.ejmech.2014.09.039
Effect of triazine derivatives on neuronal nicotinic receptors Vazquez-Romero A, Criado M, Messeguer A, Vidal-Mosquera M, Mulet J, Sala F, Sala S ACS Chem Neurosci 2014 5(8):683 https://doi.org/10.1021/cn5000748
Functional MRI in mice lacking IP3-dependent calcium signaling in astrocytes Jego P, Pacheco-Torres J, Araque A, Canals S J Cereb Blood F Met 2014 34(10):1599 https://doi.org/10.1038/jcbfm.2014.144
Functional MRI of long-term potentiation: imaging network plasticity Alvarez-Salvado E, Pallares V, Moreno A, Canals S Philos Trans R Soc B-Biol Sci 2014 369 (1633) https://doi.org/10.1098/rstb.2013.0152
Phenotyping the central nervous system of the embryonic mouse by magnetic resonance microscopy Martinez-Martinez MA, Pacheco-Torres J, Borrell V, Canals S NeuroImage 2014 97:95 https://doi.org/10.1016/j.neuroimage.2014.04.043
Amelioration of ischemic brain damage by peritoneal dialysis, Godino MC, Romera VG, Sanchez-Tomero JA, Pacheco J, Canals S, Lerma J, Vivancos J, Moro MA, Torres M, Lizasoain I, Sanchez-Prieto J J Clin Invest 2013 123(10):4359 https://doi.org/10.1172/JCI67284
Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes Del Pino I, Garcia-Frigola C, Dehorter N, Brotons-Mas JR, Alvarez-Salvado E, Martinez de Lagran M, Ciceri G, Gabaldon MV, Moratal D, Dierssen M, Canals S, Marin O, Rico B Neuron 2013 79(6):1152 https://doi.org/10.1016/j.neuron.2013.07.010
Neurophysiological, metabolic and cellular compartments that drive neurovascular coupling and neuroimaging signals Moreno A, Jego P, de la Cruz F, Canals S Front Neuroenergetics 2013 5:3 https://doi.org/10.3389/fnene.2013.00003
Expression and functional properties of a7 acetylcholine nicotinic receptors are modified in the presence of other receptor subunits Criado M, Valor LM, Mulet J, Gerber S, Sala S, Sala F J Neurochem 2012 123(4):504 https://doi.org/10.1111/j.1471-4159.2012.07931.x
A small cytoplasmic region adjacent to the fourth transmembrane segment of the alpha 7 nicotinic receptor is essential for its biogenesis Criado M, Mulet J, Gerber S, Sala S, Sala F FEBS Lett 2011 585(15):2477 https://doi.org/10.1016/j.febslet.2011.06.028
Biocytin-Derived MRI Contrast Agent for Longitudinal Brain Connectivity Studies Mishra A, Schuz A, Engelmann J, Beyerlein M, Logothetis NK, Canals S ACS Chem Neurosci 2011 2(10):578 https://doi.org/10.1021/cn200022m
Mutants of beta-strand beta 3 and the loop B in the interface between alpha 7 subunits of a homomeric acetylcholine receptor show functional and pharmacological alterations Criado M, Mulet J, Gerber S, Sala S, Sala F J Neurochem 2011 118(6):968 https://doi.org/10.1111/j.1471-4159.2011.07381.x
Substitutions of amino acids in the pore domain of homomeric alpha 7 nicotinic receptors for analogous residues present in heteromeric receptors modify gating, rectification and binding properties Criado M, Svobodova L, Mulet J, Sala F, Sala S J Neurochem 2011 119(1):40 https://doi.org/10.1111/j.1471-4159.2011.07398.x
Role of loop 9 on the function of neuronal nicotinic receptors Criado M, Castillo M, Mulet J, Sala F, Sala S BBA-Biomembranes 2010 1798(3):654 https://doi.org/10.1016/j.bbamem.2009.12.013
Role of the extracellular transmembrane domain interface in gating and pharmacology of a heteromeric neuronal nicotinic receptor Aldea M, Castillo M, Mulet J, Sala S, Criado M, Sala F J Neurochem 2010 113(4):1036 https://doi.org/10.1111/j.1471-4159.2010.06665.x
The loop between beta-strands beta 2 and beta 3 and its interaction with the N-terminal alpha-helix is essential for biogenesis of alpha 7 nicotinic receptors Criado M, Mulet J, Castillo M, Gerber S, Sala S, Sala F J Neurochem 2010 112(1):103 https://doi.org/10.1111/j.1471-4159.2009.06439.x

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