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Carolina Luna
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Mar Francés

Nuestro objetivo es dilucidar los mecanismos de función y disfunción del cerebro y utilizar este

conocimiento para mejorar la vida de las personas

Últimas noticias

14th IN Progress Report Workshop (14th and 15th October)
14 de octubre de 2021
Descubren una proteína que protege al cerebro de la enfermedad de Alzheimer
3 de marzo de 2022
Día Internacional de la Mujer en la Ciencia en el Instituto de Neurociencias
11 de febrero de 2022
Dos millones y medio de euros para estudiar cómo se forman los circuitos sensoriales en el cerebro en desarrollo
26 de abril de 2022
Prueba
El Instituto de Neurociencias hace balance de 2021 y presenta sus tradicionales 12 hitos en investigación
21 de enero de 2022
El Instituto de Neurociencias recibe el Distintivo de Igualdad del CSIC
8 de marzo de 2022
El Instituto de Neurociencias renueva la Cátedra de Neurobiología ‘Remedios Caro Almela’
30 de mayo de 2022
El Investigador del Instituto de Neurociencias Luis Miguel Gutiérrez participa en la exposición internacional “Cajal 2022, una visión artística”
8 de abril de 2022
El Premio Nobel de Medicina David Julius visitará el Instituto de Neurociencias
3 de junio de 2022
Encuentro de investigación: ISABIAL-Instituto de Neurociencias, 7 de junio
3 de junio de 2022
International Workshop on Chronic Pain and Itch: Mechanisms and Circuits (October 20-22)
20 de octubre de 2021
RECURSO
La AVI y el Instituto de Neurociencias se reúnen para impulsar el desarrollo de proyectos de innovación en el ámbito de la salud
18 de octubre de 2021
La investigadora del Instituto de Neurociencias Ángela Nieto ingresa en la Academia de Ciencias de Francia
26 de enero de 2022
Master in Neuroscience: Five International Scholarships for the course 2022-23
10 de marzo de 2022
Pint of Science Alicante – Una mente maravillosa, 9 de mayo
4 de mayo de 2022
Semana Mundial del Cerebro 14-18 Marzo
14 de marzo de 2022
Synapses Lecture Series – 24 Feb 2022
18 de febrero de 2022
cerebro transparente
Visualizan los circuitos de oxitocinay vasopresina en 3D con una resolución sin precedentes
13 de octubre de 2021
Todas las noticias

Investigaciones destacadas

A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3
A Complex Code of Extrinsic Influences on Cortical Progenitor Cells of Higher Mammals
A gene regulatory network to control EMT programs in development and disease
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair
A Proteomic Analysis Reveals the Interaction of GluK1 Ionotropic Kainate Receptor Subunits with Go Proteins
A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels
A Retino retinal Projection Guided by Uncc Emerged in Species with Retinal Waves
A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves
A right handed signalling pathway drives heart looping in vertebrates
A right-handed signalling pathway drives heart looping in vertebrates
A Serrate-Notch-Canoe complex mediates glial-neuroepithelial cell interactions essential during Drosophila optic lobe development,
A Wide Diversity of Cortical GABAergic Interneurons Derives from the Embryonic Preoptic Area
A Zic2-regulated switch in a noncanonical Wnt/betacatenin pathway is essential for the formation of bilateral circuits
autores SciAdv
Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming
destacado
Body-fat sensor triggers ribosome maturation in the steroidogenic gland to initiate sexual maturation in Drosophila
C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease
cAMP Response Element-Binding Protein Is a Primary Hub of Activity-Driven Neuronal Gene Expression
Captivating New Roles of F-Actin Cortex in Exocytosis anc Bulk Endocytosis in Neurosecretory Cells
CBP and SRF co regulate dendritic growth and synaptic maturation
CBP and SRF co-regulate dendritic growth and synaptic maturation
CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement
Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer’s disease
ScienceAdvances
Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain
Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells
Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells
Conserved miR-8/miR-200 Defines a Glial Niche that Controls Neuroepithelial Expansion and Neuroblast Transition
Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity
photo zoom agosto
Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly
Diverse Thalamocortical Short-Term Plasticity Elicited by Ongoing Stimulation
Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice
CellReports Dominguez
Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb
eEF1A Mediates the Nuclear Export of SNAG-Containing Proteins via the Exportin5-Aminoacyl-tRNA Complex
eLife
Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts
Emergent Growth Cone Responses to Combinations of Slit1 and Netrin 1 in Thalamocortical Axon Topography
Endocrine remodelling of the adult intestine sustains reproduction in Drosophila
Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells
Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells
Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes
Evolution of cortical neurogenesis in amniotes controlled by Robo signaling levels
Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels
Finding influential nodes for integration in brain networks using optimal percolation theory
Finding influential nodes for integration in brain networks using optimal percolation theory
FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons
Focal Adhesion Kinase Modulates Radial Glia-Dependent Neuronal Migration through Connexin-26
Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth
Frequency-Dependent Gating of Hippocampal-Neocortical Interactions
Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes
Genomic landscape of transcriptional and epigenetic dysregulation in early-onset polyglutamine disease
Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibiton
Germinal Zones in the Developing Cerebral Cortex of Ferret: Ontogeny, Cell Cycle Kinetics, and Diversity of Progenitors
Glial-secreted Netrins regulate Robo1/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem and progenitor cell division
Heteromers of amyloid precursor protein in cerebrospinal fluid
Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain
Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation
NatNeurosci Barco
Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus
Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features
Increased Grik4 Gene Dosage Causes Imbalanced Circuit Output and Human Disease-Related Behaviors
Inhibition of gamma-Secretase Leads to an Increase in Presenilin-1
Interspersed Distribution of Selectivity to Kinematic Stimulus Features in Supragranular Layers of Mouse Barrel Cortex
Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation
NatCommAutores
KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects
Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells
Lineage-specific laminar organization of cortical GABAergic interneurons
Loss of Kdmc Causes Spurious Transcription and Prevents the Fine Tuning of Activity Regulated Enhancers in Neurons
Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons
Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction
Mapping microglia and astrocyte activation in vivo using diffusion MRI
eLife autores
Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum
Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates
jama psychiatry
Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence
Phenotyping the central nervous system of the embryonic mouse by magnetic resonance microscopy
PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation
JNeurosci
Piezo2 mediates low-threshold mechanically-evoked pain in the cornea
Science mayo
Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice.
Prenatal thalamic waves regulate cortical area size prior to sensory processing
Reciprocal Repression between Sox3 and Snail Transcription Factors Defines Embryonic Territories at Gastrulation
Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules
Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules
Regulation of cerebral cortex size and folding by expansion of basal progenitors
photoEMBOJ Borrell
Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium
Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch
Secondary loss of miR-3607 reduced cortical progenitor amplification during rodent evolution
Silent Learning
Slit/Robo Signaling Modulates the Proliferation of Central Nervous System Progenitors
Snail1-induced partial epitelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease
Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth
Statistical Wiring of Thalamic Receptive Fields Optimizes Spatial Sampling of the Retinal Image
Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis
Synergism between canoe and scribble mutations causes tumorlike overgrowth via Ras activation in neural stem cells and epithelia
The Actin-Binding Protein Canoe/AF-6 Forms a Complex with Robo and Is Required for Slit-Robo Signaling during Axon Pathfinding at the CNS Midline
The apolipoprotein receptor LRP3 compromises APP levels
The beta-amyloid peptide compromises Reelin signaling in Alzheimer’s disease
The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells
The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells
The evolutionary history of Ephs and ephrins: towards multicellular organisms
The Hippo Pathway Core Cassette Regulates Asymmetric Cell Division
The Immunosuppressant Macrolide Tacrolimus Activates Cold Sensing TRPM Channels
The immunosuppressant macrolide tacrolimus activates cold-sensing TRPM8 channels
The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors
The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation
The speed – curvature power law in Drosophila larval locomotion
Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate,
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
Uncoupling of EphA/ephrinA signaling and spontaneous activity in neural circuit wiring
Widespread Vestibular Activation of the Rodent Cortex
Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain
Zic2-Dependent Axon Midline Avoidance Controls the Formation of Major Ipsilateral Tracts in the CNS
Investigaciones destacadas previas

CERTIFICADOS, DISTINCIONES Y ALIANZAS
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Programas de Investigación

2
Regulación y diferenciación de células madre neurales
Plasticidad celular en enfermedad y reparación cerebral
Construcción y adaptación de los circuitos neuronales en redes funcionales
Modulación sináptica de los circuitos neuronales y la conducta
Bases genéticas y epigenéticas de la individualidad y el envejecimiento
Neurobiología del dolor y la inflamación
Cognición y comportamiento humano
Investigación traslacional de las enfermedades neurológicas y psiquiátricas

Nuestro proyecto se basa en ocho programas de INVESTIGACIÓN y un esquema
de servicio y transferencia a la sociedad estructurada en cuatro ejes de actuación:

SLIDER

FORMACIÓN

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INNOVACIÓN

TRASLACIÓN

COMUNICACIÓN