Desarrollo, Plasticidad y Reprogramación de Circuitos Sensoriales

Líneas de investigación

El objetivo general de nuestro laboratorio es el de comprender los mecanismos celulares y moleculares implicados en la guía axonal de los principales tractos axonales del SNC de mamíferos. En particular, nuestro interés se centra en estudiar cómo se forma uno de los sistemas de guía axonal más complejos en el SNC de mamíferos: el sistema talamocortical. A través de este sistema, la información sensorial es transmitida a la corteza cerebral de manera topográfica, produciéndose la adquisición de la percepción de los estímulos que nos rodean. Asimismo, el desarrollo anormal del sistema tálamocortical podría estar implicado en algunas enfermedades neurológicas, tales como el autismo o la epilepsia.

En nuestro laboratorio estamos interesados en el análisis de dos mecanismos básicos del desarrollo de la proyección tálamocortical: (1) la especificación celular, es decir, el proceso por el cual se generan los distintos tipos de neuronas del tálamo dorsal (visuales, auditivas, etc), y (2) cómo se produce la guía axonal e integración de cada una de estas proyecciones topográficas en el circuito cortical. Para estudiar estos mecanismos usamos el ratón como modelo experimental y empleamos una aproximación multidisciplinar que incluye métodos de embriología experimental, técnicas avanzadas de imagen en tiempo real y métodos estándar de histología, biología celular y molecular.

Publicaciones relevantes

Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids. Eduardo Leyva-Díaz, Emily S. Wilson, Guillermina López-Bendito Cell Stem Cell. 2024 31(3): p283-284 https://doi.org/10.1016/j.stem.2024.02.008
Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice. Ángela Rodríguez-Prieto, Isabel Mateos-White, Mar Aníbal-Martínez, Carmen Navarro-González, Cristina Gil-Sanz, Yaiza Domínguez-Canterla, Ana González-Manteiga, Verónica Del Buey Furió, Guillermina López-Bendito, Pietro Fazzari. Life Science Alliance. 2024 Volume 7, No. 9 https://doi.org/10.26508/lsa.202302250
The superior colliculus: New insights into an evolutionarily ancient structure. Teresa Guillamón-Vivancos , Fabrizio Favaloro , Francesco Dori , Guillermina López-Bendito. Current Opinion in Neurobiology. 2024 89: December 2024, 102926 https://doi.org/10.1016/j.conb.2024.102926
Input-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus Teresa Guillamón-Vivancos, Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Juan Antonio Moreno-Bravo, Miguel Valdeolmillos, Francisco J. Martini, Guillermina López-Bendito Science 2022 Aug 19; 377(6608):845-850 https://doi.org/10.1126/science.abq2960
Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming Herrero-Navarro Á, Puche-Aroca L, Moreno-Juan V, Sempere-Ferràndez A, Espinosa A, Susín R, Torres-Masjoan L, Leyva-Díaz E, Karow M, Figueres-Oñate M, López-Mascaraque L, López-Atalaya JP, Berninger B, López-Bendito G Sci Adv 2021 7(15):eabe8978 https://doi.org/10.1126/sciadv.abe8978
Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons Company V, Andreu-Cervera A, Madrigal MP, Andrés B, Almagro-García F, Chédotal A, López-Bendito G, Martinez S, Echevarría D, Moreno-Bravo JA, Puelles E Front Cell Dev Biol 2021 9:682067 https://doi.org/10.3389/fcell.2021.682067
Spontaneous activity in developing thalamic and cortical sensory networks Martini FJ,Guillamón-Vivancos T, Moreno-Juan V, Valdeolmillos M, López-Bendito G. Neuron 2021 109(16):2519 https://doi.org/10.1016/j.neuron.2021.06.026
Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice. Antón-Bolaños N, Sempere-Ferrandez A, Guillamon-Vivancos T, Martini FJ, Perez-Saiz L, Gezelius H, Filipchuk A, Valdeolmillos M, Lopez-Bendito G Science 2019 364(6444):987 https://doi.org/10.1126/science.aav7617
Prenatal thalamic waves regulate cortical area size prior to sensory processing Moreno-Juan V, Filipchuk A, Anton-Bolaños N, Mezzera C, Gezelius H, Andres B, Rodriguez-Malmierca L, Susin R, Schaad O, Iwasato T, Schüle R, Rutlin M, Nelson S, Ducret S, Valdeolmillos M, Rijli FM, Lopez-Bendito G Nat Commun 2017 8:14172 https://doi.org/10.1038/ncomms14172
FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons Leyva-Diaz E, del Toro D, Menal MJ, Cambray S, Susin R, Tessier-Lavigne M, Klein R, Egea J, Lopez-Bendito G Curr Biol 2014 24(5):494 https://doi.org/10.1016/j.cub.2014.01.042

Jefe de grupo

Guillermina López Bendito Profesor de Investigación CSIC

Investigador Senior

Francisco Martini Profesor Doctor UMH

Investigador emergente

Mª Teresa Guillamón Vivancos Junior Leader La Caixa

Investigador emergente

Eduardo Leyva Díaz Investigador CIDEGENT

Investigador postdoctoral

Fabrizio Favaloro

Investigador postdoctoral

Verónica Miguela Fernández

Investigador postdoctoral

Elena Pérez Montoyo

Investigador postdoctoral

Daniel Torres Romero

Investigador postdoctoral

Investigador postdoctoral

Investigador postdoctoral

Emily Sarah Wilson

Investigador predoctoral

Mar Aníbal Martínez

Investigador predoctoral

Pablo Castellano Ruiz

Investigador predoctoral

Investigador predoctoral

Eleni Giannopoulou

Investigador predoctoral

Chrysoula Giasafaki

Investigador predoctoral

Lorenzo Alberto Puche Aroca

Personal técnico

Belén Andrés Bayón

Personal técnico

Luis Miguel Rodríguez Malmierca

Personal técnico

María Aurelia Torregrosa Mira

Personal administración

Helena Campos Martín Asistente laboratorio

Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids. Eduardo Leyva-Díaz, Emily S. Wilson, Guillermina López-Bendito Cell Stem Cell. 2024 31(3): p283-284 https://doi.org/10.1016/j.stem.2024.02.008
Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice. Ángela Rodríguez-Prieto, Isabel Mateos-White, Mar Aníbal-Martínez, Carmen Navarro-González, Cristina Gil-Sanz, Yaiza Domínguez-Canterla, Ana González-Manteiga, Verónica Del Buey Furió, Guillermina López-Bendito, Pietro Fazzari. Life Science Alliance. 2024 Volume 7, No. 9 https://doi.org/10.26508/lsa.202302250
The superior colliculus: New insights into an evolutionarily ancient structure. Teresa Guillamón-Vivancos , Fabrizio Favaloro , Francesco Dori , Guillermina López-Bendito. Current Opinion in Neurobiology. 2024 89: December 2024, 102926 https://doi.org/10.1016/j.conb.2024.102926
Spontaneous Thalamic Activity Modulates the Cortical Innervation of the Primary Visual Nucleus of the Thalamus. Moreno-Juan, V., Aníbal-Martínez, M., Herrero-Navarro, Á., Valdeolmillos, M., Martini, F.J., López-Bendito, G. Neuroscience 2023 508: 87-97 https://doi.org/10.1016/j.neuroscience.2022.07.022
Mesoscale calcium imaging in vivo: evolution and contribution to developmental neuroscience. Guillamón-Vivancos T, Vandael D, Torres D, López-Bendito G, Martini FJ. Front Neurosci. 2023 17: 1210199 https://doi.org/10.3389/fnins.2023.1210199
Building thalamic neuronal networks during mouse development. Huerga-Gómez I, Martini FJ, López-Bendito G. Front Neural Circuits. 2023 17: 1098913 https://doi.org/10.3389/fncir.2023.1098913
Input-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus Teresa Guillamón-Vivancos, Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Juan Antonio Moreno-Bravo, Miguel Valdeolmillos, Francisco J. Martini, Guillermina López-Bendito Science 2022 Aug 19; 377(6608):845-850 https://doi.org/10.1126/science.abq2960
Cross-Modal Plasticity in Brains Deprived of Visual Input Before Vision. López-Bendito, G., Aníbal-Martínez, M., Martini, F.J. Annu Rev Neurosci . 2022 45: 471-489 https://doi.org/10.1146/annurev-neuro-111020-104222
Dynamic interplay between thalamic activity and Cajal-Retzius cells regulates the wiring of cortical layer 1. Genescu, I., Aníbal-Martínez, M., Kouskoff, V., Chenouard, N., Mailhes-Hamon, C., Cartonnet, H., Lokmane, L., Rijli, F.M., López-Bendito, G., Gambino, F., Garel, S. Cell Rep. 2022 39(2): 110667 https://doi.org/10.1016/j.celrep.2022.110667
A unique bipartite Polycomb signature regulates stimulus-response transcription during development Kitazawa T, Machlab D, Joshi O, Maiorano N, Kohler H, Ducret S, Kessler S, Gezelius H, Soneson C, Papasaikas P, López-Bendito G, Stadler MB, Rijli FM Nat Genet 2021 53(3):379 https://doi.org/10.1038/s41588-021-00789-z
Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation Alçada-Morais S, Gonçalves N, Moreno-Juan V, Andres B, Ferreira S, Marques JM, Magalhães J, Rocha JMM, Xu X, Partidário M, Cunha RA, López-Bendito G, Rodrigues RJ Cereb Cortex 2021 31(12):5652 https://doi.org/10.1093/cercor/bhab188
Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming Herrero-Navarro Á, Puche-Aroca L, Moreno-Juan V, Sempere-Ferràndez A, Espinosa A, Susín R, Torres-Masjoan L, Leyva-Díaz E, Karow M, Figueres-Oñate M, López-Mascaraque L, López-Atalaya JP, Berninger B, López-Bendito G Sci Adv 2021 7(15):eabe8978 https://doi.org/10.1126/sciadv.abe8978
Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons Company V, Andreu-Cervera A, Madrigal MP, Andrés B, Almagro-García F, Chédotal A, López-Bendito G, Martinez S, Echevarría D, Moreno-Bravo JA, Puelles E Front Cell Dev Biol 2021 9:682067 https://doi.org/10.3389/fcell.2021.682067
Spontaneous activity in developing thalamic and cortical sensory networks Martini FJ,Guillamón-Vivancos T, Moreno-Juan V, Valdeolmillos M, López-Bendito G. Neuron 2021 109(16):2519 https://doi.org/10.1016/j.neuron.2021.06.026
Netrin-1/DCC Signaling Differentially Regulates the Migration of Pax7, Nkx6.1, Irx2, Otp, and Otx2 Cell Populations in the Developing Interpeduncular Nucleus García-Guillén IM, Alonso A, Morales-Delgado N, Andrés B, Puelles L, López-Bendito G, Marín F, Aroca P Front Cell Dev Biol 2020 8:588851 https://doi.org/10.3389/fcell.2020.588851
Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring Riva M, Genescu I, Habermacher C, Orduz D, Ledonne F, Rijli FM, López-Bendito G, Coppola E, Garel S, Angulo MC, Pierani A eLife 2019 8:e50503 https://doi.org/10.7554/eLife.50503
Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice. Antón-Bolaños N, Sempere-Ferrandez A, Guillamon-Vivancos T, Martini FJ, Perez-Saiz L, Gezelius H, Filipchuk A, Valdeolmillos M, Lopez-Bendito G Science 2019 364(6444):987 https://doi.org/10.1126/science.aav7617
Development of the Thalamocortical Interactions: Past, Present and Future Lopez-Bendito G Neuroscience 2018 385:67 https://doi.org/10.1016/j.neuroscience.2018.06.020
Developmental interactions between thalamus and cortex: a true love reciprocal story Anton-Bolaños N, Espinosa A, Lopez-Bendito G Curr Opin Neurobiol 2018 52:33 https://doi.org/10.1016/j.conb.2018.04.018
Developmental neuroscience (2018) Kolodkin AL, Lopez-BenditoG Curr Opin Neurobiol 2018 53:III https://doi.org/10.1016/j.conb.2018.https://doi.org/10.010
Impact of thalamocortical input on barrel cortex development Martini FJ, Moreno-Juan V, Filipchuk A, Valdeolmillos M, Lopez-Bendito G Neuroscience 2018 368:246 https://doi.org/10.1016/j.neuroscience.2017.04.005
Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes Gezelius H, Moreno-Juan V, Mezzera C, Thakurela S, Rodriguez-Malmierca LM, Pistolic J, Benes V, Tiwari VK, Lopez-Bendito G Cereb Cortex 2017 27(11):5054 https://doi.org/10.1093/cercor/bhw290
Prenatal thalamic waves regulate cortical area size prior to sensory processing Moreno-Juan V, Filipchuk A, Anton-Bolaños N, Mezzera C, Gezelius H, Andres B, Rodriguez-Malmierca L, Susin R, Schaad O, Iwasato T, Schüle R, Rutlin M, Nelson S, Ducret S, Valdeolmillos M, Rijli FM, Lopez-Bendito G Nat Commun 2017 8:14172 https://doi.org/10.1038/ncomms14172
Balancing family with a successful career in neuroscience Poirazi P, Belin D, Gräff J, Hanganu-Opatz IL, Lopez-Bendito G Eur J Neurosci 2016 44(2):1797 https://doi.org/10.1111/ejn.13280
Cross-modal plasticity in sensory deprived animal models: From the thalamocortical development point of view Mezzera C, Lopez-Bendito G J Chem Neuroanat 2016 75:32 https://doi.org/10.1016/j.jchemneu.2015.09.005
Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion Moreno-Bravo JA, Martinez-Lopez JE, Madrigal MP, Kim M, Mastick GS, Lopez-Bendito G, Martinez S, Puelles E Brain Struct Funct 2016 221(1):665 https://doi.org/10.1007/s00429-014-0932-4
Getting published: how to write a successful neuroscience paper Schwabe L, Lopez-Bendito G, Ribeiro C Eur J Neurosci 2016 43(8):992 https://doi.org/10.1111/ejn.13215
Moving on: mobility for early-career neuroscientists Grubb MS, Hoogenraad CC, Schwabe L, Lopez-Bendito G Eur J Neurosci 2016 44(6):2285 https://doi.org/10.1111/ejn.13339
Antagonistic Effects of BACE1 and APH1B-gamma-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse Barao S, Gartner A, Leyva-Diaz E, Demyanenko G,Munck S, Vanhoutvin T, Zhou L, Schachner M, Lopez-Bendito G, Maness PF, De Strooper B Cell Rep 2015 12(9):1367 https://doi.org/10.1016/j.celrep.2015.07.059
DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity Castillo-Paterna M, Moreno-Juan V, Filipchuk A, Rodriguez-Malmierca L, Susin R, Lopez-Bendito G EMBO Rep 2015 16(7):851 https://doi.org/10.15252/embr.201439882
Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development Morello F, Prasad AA, Rehberg K, de Sa RV, Anton-Bolaños N, Leyva Diaz E, Adolfs Y, Tissir F, Lopez-Bendito G, Pasterkamp RJ J Neurosci 2015 35(42):14205 https://doi.org/10.1523/JNEUROSCI.1840-15.2015
FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons Leyva-Diaz E, del Toro D, Menal MJ, Cambray S, Susin R, Tessier-Lavigne M, Klein R, Egea J, Lopez-Bendito G Curr Biol 2014 24(5):494 https://doi.org/10.1016/j.cub.2014.01.042
Inputs from the thalamocortical system on axon pathfinding mechanisms Garel S, Lopez-Bendito G Curr Opin Neurobiol 2014 27:143 https://doi.org/10.1016/j.conb.2014.03.013
In and Out from the Cortex: Development of Major Forebrain Connections Leyva-Diaz E, Lopez-Bendito G Neuroscience 2013 254:26 https://doi.org/10.1016/j.neuroscience.2013.08.070
Uncoupling of EphA/ephrinA signaling and spontaneous activity in neural circuit wiring Benjumeda I, Escalante A, Law C, Morales D, Chauvin G, Muca G, Coca Y, Lopez-Bendito G, Kania A, Martinez-Otero L, Herrera E J Neurosci 2013 33(46):18208 https://doi.org/10.1523/JNEUROSCI.1931-13.2013
Cell replacement therapies for nervous system regeneration Lopez-Bendito G, Arlotta P Dev Neurobiol 2012 72(2):145 https://doi.org/10.1002/dneu.20897
Development and plasticity of thalamocortical systems Jabaudon D, Lopez-Bendito G Eur J Neurosci 2012 35(10):1522 https://doi.org/10.1111/j.1460-9568.2012.08117.x
Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain Molnar Z, Garel S, Lopez-Bendito G, Maness P, Price DJ Eur J Neurosci 2012 35(10):1573 https://doi.org/10.1111/j.1460-9568.2012.08119.x
Shaping brain connections through spontaneous neural activity Yamamoto N, Lopez-Bendito G Eur J Neurosci 2012 35(10):1595 https://doi.org/10.1111/j.1460-9568.2012.08101.x
Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth Mire E, Mezzera C, Leyva-Diaz E, Paternain AV, Squarzoni P, Bluy L, Castillo-Paterna M, Lopez MJ, Peregrin S, Tessier-Lavigne M, Gare S, Galceran J, Lerma J, Lopez-Bendito G Nat Neurosci 2012 15(8):1134 https://doi.org/10.1038/nn.3160
The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors Marcos-Mondejar P, Peregrin S, Li JY, Carlsson L, Tole S, Lopez-Bendito G J Neurosci 2012 32(13):4372 https://doi.org/10.1523/JNEUROSCI.5851-11.2012
Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness Sanchez-Alcaniz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, Lopez-Bendito G, Stumm R, Marin O Neuron 2011 69(1):77 https://doi.org/10.1016/j.neuron.2010.12.006
Emergent Growth Cone Responses to Combinations of Slit1 and Netrin 1 in Thalamocortical Axon Topography Bielle F, Marcos-Mondejar P, Leyva-Diaz E, Lokmane L, Mire E, Mailhes C, Keita M, Garcia N, Tessier-Lavigne M, Garel S, Lopez-Bendito G Curr Biol 2011 21(20):1748 https://doi.org/10.1016/j.cub.2011.09.008
Fgfr3 Regulates Development of the Caudal Telencephalon Moldrich RX, Mezzera C, Holmes WM, Goda S, Brookfield SJ, Rankin AJ, Barr E, Kurniawan N, Dewar D, Richards LJ,Lopez-Bendito G, Iwata T Dev Dynam 2011 240(6):1586 https://doi.org/10.1002/dvdy.22636
Slit2 Activity in the Migration of Guidepost Neurons Shapes Thalamic Projections during Development and Evolution Bielle F, Marcos-Mondejar P, Keita M, Mailhes C, Verney C, Nquyen Ba-Charvet K, Tessier-Lavigne M, Lopez-Bendito G, Garel S Neuron 2011 69(6):1085 https://doi.org/10.1016/j.neuron.2011.02.026

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Input-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus

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Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice.

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