Lines of investigation

Our research focuses on the molecular bases of neuronal plasticity, learning and memory, and other long-lasting modifications of the animal’s behavior. More precisely, we are investigating the role of specific transcription and epigenetic factors in these processes. We also aim to determine how the malfunction of epigenetic mechanisms leads to different pathological situations in the nervous system. To tackle these questions, we use a multidisciplinary approach that combines mouse genetics, genomics, behavioral and electrophysiological analyses and molecular and cellular biology techniques. From the methodological point of view, we are particularly interested in the application of genomic profiling techniques based on next generation sequencing (NGS) and epigenetic editing approaches in the nervous system.

We currently work on two main lines of research:

• Interplay of transcriptional and epigenetic mechanisms in activity-dependent transcription: Alterations in the patterns of neuronal gene expression are thought to underlie the long-lasting changes in the strength of synaptic connections responsible for the encoding of memories in the nervous system. We are investigating the participation of specific activity-regulated transcription factors, such as CREB and SRF, and epigenetic enzymes, such as CBP and p300, in this process. We are also interested in determining the role of the covalent modification of chromatin in neuroplasticity.

• Contribution of epigenetic mechanisms to intellectual disability (ID) disorders: We investigate the contribution of epigenetic mechanisms, such as histone acetylation and methylation, to the pathoetiology of different neurological conditions associated with cognitive impairments and autism, including Rubinstein-Taybi syndrome and X-linked intellectual disability. Towards this end, we generate and characterize mouse models for these conditions, explore the molecular causes of the disease and tackle new therapies.

Representative Publications

Postdoctoral Researcher
Postdoctoral Researcher
Postdoctoral Researcher
Postdoctoral Researcher
Predoctoral Researcher
Predoctoral Researcher
Predoctoral Researcher
Predoctoral Researcher
Predoctoral Researcher
Predoctoral Researcher
Predoctoral Researcher
Technical personnel
Technical personnel

Research groups of Unit

Molecular Neurobiology and Neuropathology

Research groups of Scientific Program