Instituto de Neurociencias de Alicante -

Jefe de grupo

Profesor de Investigación CSIC

Teléfono 965 91 9243 - Lab 026-027-028

Email anieto@umh.es

Grupo

Plasticidad Celular en Desarrollo y Enfermedad
https://in.umh-csic.es/grupo3902

Programas

Proyectos

Artículos

A hormetic transcriptional program coregulates invasion, proliferation and dormancy to define metastatic potential. Jiménez-Castaño, R., Narwade, N., Moreno-Bueno, G., Sánchez-Laorden, B., Galcerán, J., Youssef, K.K. and Nieto, M.A. Nature Communications. 2026 17: 3425 https://doi.org/10.1038/s41467-026-70242-4
Enhanced RNA-targeting CRISPR-Cas technology in zebrafish. Ismael Moreno-Sánchez, Luis Hernández-Huertas, Daniel Nahón-Cano, Pedro Manuel Martínez-García, Anthony J. Treichel, Carlos Gómez-Marin, Laura Tomás-Gallardo, Gabriel da Silva Pescador, Gopal Kushawah, Rhonda Egidy, Anoja Perera, Alejandro Díaz-Moscoso, Alejandra Cano-Ruiz, John A. Walker II, Manuel J. Muñoz, Kevin Holden, Joan Galcerán, M. Ángela Nieto, Ariel A. Bazzini & Miguel A. Moreno-Mateos. Nature Communications. 2025 16; Article number: 2591 https://doi.org/10.1038/s41467-025-57792-9
Melanoma innervation, noradrenaline and cancer progression in zebrafish xenograft model. Francesca Lorenzini, Johanna Marines, Julien Le Friec, Nam Do Khoa, Maria Angela Nieto, Berta Sanchez-Laorden, Maria Caterina Mione, Laura Fontenille & Karima Kissa. Cell Death Discov. 2025 11- Article num. 260 (2025) https://doi.org/10.1038/s41420-025-02523-8
Mutual repression between Pax2 and Snail factors regulates the epithelial/mesenchymal state during intermediate mesoderm differentiation. Juan M Fons ,Oscar H Ocaña ,M Angela Nieto, Development. 2025 152(16): dev204848 https://doi.org/10.1242/dev.204848
Intron detention tightly regulates the stemness/differentiation switch in the adult neurogenic niche. Gonzalez-Iglesias A, Arcas A, Domingo-Muelas A, Mancini E, Galcerán J, Valcárcel J, Fariñas I and Nieto MA. Nature Communications. 2024 15, 2837 https://doi.org/10.1038/s41467-024-47092-z
Epithelial–mesenchymal transition in tissue repair and degeneration. Youssef, K.K. and Nieto, M.A. Nat. Rev. Mol. Cell. Biol. 2024 25, 720-739 https://doi.org/10.1038/s41580-024-00733-z
Two distinct Epithelial to Mesenchymal Transition Programmes Control Invasion and Inflammation in Segregated Tumour Cell Populations. Kass Youssef, K., Narwade, N., Arcas, A., Marquez-Galera, A., Jiménez, R., Lopez-Blau, C., Fazilaty, H., García-Gutierrez, D., Cano, A., Galcerán, J., Moreno-Bueno, G., Lopez-Atalaya, J.P. and Nieto, M.A. Nature Cancer. 2024 https://doi.org/10.1038/s43018-024-00839-5
Microenvironmental Snail1-induced immunosuppression promotes melanoma growth. Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B. Oncogene 2023 42 (36), pp. 2659 - 2672 https://doi.org/10.1038/s41388-023-02793-5
Antifibrotic drugs as therapeutic tools in resistant melanoma. Sanchez-Laorden B, Nieto MA. EMBO Mol Med. 2022 14(3):e15449 - Editorial https://doi.org/10.15252/emmm.202115449
Are You Interested or Afraid of Working on EMT? Nieto MA Methods Mol Biol 2021 2179:19 https://doi.org/10.1007/978-1-0716-0779-4_4
50+shades of EMT in 20 years of embryo-cancer bonding Nieto MA Nat Rev Mol Cell Biol 2020 21(10):563 https://doi.org/10.1038/s41580-020-00287-w
G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas Palacios-Garcia J, Sanz-Flores M, Asensio A, Alvarado R, Rojo-Berciano S, Stamatakis K, Paramio JM, Cano A, Nieto MA, Garcia-Escudero R, Mayor F Jr, Ribas C Int J Cancer 2020 147(1):218 https://doi.org/10.1002/ijc.32838
Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B Dev Cell 2020 54(5):593 https://doi.org/10.1016/j.devcel.2020.06.021
Glucose Metabolism Takes Center Stage in Epithelial-Mesenchymal Plasticity Kass Youssef K, Nieto MA Dev Cell. 2020 53(2):133 https://doi.org/10.1016/j.devcel.2020.03.021
Guidelines and definitions for research on epithelial-mesenchymal transition Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RJY, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G, EMT International Association (TEMTIA) Nat Rev Mol Cell Biol 2020 21(6):341 https://doi.org/10.1038/s41580-020-0237-9
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition Mitchel JA, Das A, O'Sullivan MJ, Stancil IT, DeCamp SJ, Koehler S, Ocaña OH, Butler JP, Fredberg JJ, Nieto MA, Bi D, Park JA Nat Commun 2020 11(1):5053 https://doi.org/10.1038/s41467-020-18841-7
Proliferation and EMT trigger heart repair Gonzalez-Iglesias A, Nieto MA Nat Cell Biol 2020 22(11):1291 https://doi.org/10.1038/s41556-020-00594-6
Reply to: Zebrafish prrx1a mutants have normal hearts Castroviejo N, Ocaña OH, Rago L, Coskun H, Arcas A, Galcerán J, Nieto MA Nature 2020 585(7826):E17 https://doi.org/10.1038/s41586-020-2675-0
The evolutionary history of Ephs and ephrins: towards multicellular organisms Arcas A, Wilkinson DG, NietoMA Mol Biol Evol 2020 37(2):379 https://doi.org/10.1093/molbev/msz222
A gene regulatory network to control EMT programs in development and disease Fazilaty H, Rago L, Kass Youssef K, Ocaña OH, Garcia-Asencio F, Arcas A, Galceran J, Nieto MA Nat Comm. 2019 10:5115 https://doi.org/10.1038/s41467-019-13091-8
MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates Rago L, Castroviejo N, Fazilaty H, Garcia-Asencio F, Ocaña OH, Galcerán J, Nieto MA Developmental Cell 2019 51(4):UNSP e3432 https://doi.org/10.1016/j.devcel.2019.09.012
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, Petersen J, Guo Y, Parks MM, Kurylo CM, Batchelder JE, Haller K, Hashimoto A, Rundqivst H, Condeelis JS, Allis CD, Drygin D, Nieto MA, Andäng M, Percipalle P, Bergh J, Adameyko I, Farrants AÖ, Hartman J, Lyden D, Pietras K, Blanchard SC, Vincent CT Nature Communications 2019 10:2110 https://doi.org/10.1038/s41467-019-10100-8
A snail tale and the chicken embryo Nieto MA Int J Dev Biol 2018 62(1-3):121 https://doi.org/10.1387/ijdb.170301mn
EMT in cancer Brabletz T, Kalluri R, Nieto MA, Weinberg RA Nat Rev Cancer 2018 18(2):128 https://doi.org/10.1038/nrc.2017.118
A right-handed signalling pathway drives heart looping in vertebrates Ocaña OH, Coskun H, Minguillon C, Murawala P, Tanaka EM, Galceran J, Muñoz-Chapuli R, Nieto MA Nature 2017 549(7670):86 https://doi.org/10.1038/nature23454
Context-specific roles of EMT programmes in cancer cell dissemination Nieto MA Nat Cell Biol 2017 19(5):416 https://doi.org/10.1038/ncb3520
Snail2 and Zeb2 repress P-cadherin to define embryonic territories in the chick embryo Acloque H, Ocana OH, Abad D, Stern CD, Nieto MA Development 2017 144(4):649 https://doi.org/10.1242/dev.142562
Upholding a role for EMT in breast cancer metastasis Ye X, Brabletz T, Kang Y, Longmore GD, Nieto MA, Stanger BZ, Yang J, Weinberg RA Nature 2017 547(7661):E1 https://doi.org/10.1038/nature22816
Upholding a role for EMT in pancreatic cancer metastasis Aiello NM, Brabletz T, Kang Y, Nieto MA, Weinberg RA, Stanger BZ Nature 2017 547(7661):E7 https://doi.org/10.1038/nature22963
EMT: 2016 Nieto MA, Huang RY, Jackson RA, Thiery JP Cell 2016 166(1):21 https://doi.org/10.1016/j.cell.2016.06.028
Identification of p53-target genes in Danio rerio Mandriani B, Castellana S, Rinaldi C, Manzoni M, Venuto S, Rodriguez-Aznar E, Galceran J, Nieto MA, Borsani G, Monti E, Mazza T, Merla G, Micale L Sci Rep 2016 6:32474 https://doi.org/10.1038/srep32474
Molecular Mechanisms Controlling the Migration of Striatal Interneurons Villar-Cerviño V, Kappeler C, Nobrega-Pereira S, Henkemeyer M, Rago L, Nieto MA, Marin O J Neurosci 2015 35(23):8718 https://doi.org/10.1523/JNEUROSCI.4317-14.2015
Snail1-induced partial epitelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease Grande MT, Sanchez-Laorden B, Lopez-Blau C, de Frutos CA, Boutet A, Arevalo M, Grant Rowe R, Weiss SJ, Lopez-Novoa JM, Nieto MA Nat Med 2015 21(9):989 https://doi.org/10.1038/nm.3901
eEF1A Mediates the Nuclear Export of SNAG-Containing Proteins via the Exportin5-Aminoacyl-tRNA Complex Mingot JM, Vega S, Cano A, Portillo F, Nieto MA Cell Rep 2013 5(3):727 https://doi.org/10.1016/j.celrep.2013.09.030
Epithelial plasticity: a common theme in embryonic and cancer cells Nieto MA Science 2013 342(6159):1234850 https://doi.org/10.1126/science.1234850
Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons Rodriguez-Aznar E, Barrallo-Gimeno A, Nieto MA J Neurosci 2013 33(12):5095 https://doi.org/10.1523/JNEUROSCI.4459-12.2013
An interview with Angela Nieto Interviewed by Eva Amsen Nieto MA Development 2012 139(7):1227 https://doi.org/10.1242/dev.077826
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation Zhang K, Rodriguez-Aznar E, Yabuta N,Owen RJ, Mingot JM, Nojima H, Nieto MA, Longmore GD EMBO J 2012 31(1):29 https://doi.org/10.1038/emboj.2011.357
Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1 Ocaña OH, Corcoles R, Fabra A, Moreno-Bueno G, Acloque H, Vega S, Barrallo-Gimeno A, Cano A, Nieto MA Cancer Cell 2012 22(6):709 https://doi.org/10.1016/j.ccr.2012.10.012
Mutual exclusion of transcription factors and cell behaviour in the definition of vertebrate embryonic territories Acloque H, Ocaña OH, Nieto MA Curr Opin Genet Dev 2012 22(4):308 https://doi.org/10.1016/j.gde.2012.03.004
The endogenous retrovirus ENS-1 provides active binding sites for transcription factors in embryonic stem cells that specify extra embryonic tissue Mey A, Acloque H, Lerat E, Gounel S, Tribollet V, Blanc S, Curton D, Birot AM, Nieto MA, Samarut J Retrovirology 2012 9:21 https://doi.org/10.1186/1742-4690-9-21
The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity Nieto MA, Cano A Semin Cancer Biol 2012 22:361 https://doi.org/10.1016/j.semcancer.2012.05.003
An Epigenetic Mark that Protects the Epithelial Phenotype in Health and Disease Heredia F, Nieto MA Cell Stem Cell 2011 8(5):462 https://doi.org/10.1016/j.stem.2011.04.011
Reciprocal Repression between Sox3 and Snail Transcription Factors Defines Embryonic Territories at Gastrulation Acloque H, Ocaña OH, Matheu A, Rizzoti K, Wise C, Lovell-Badge R, Nieto MA Dev Cell 2011 21(3):546 https://doi.org/10.1016/j.devcel.2011.07.005
Repression of Puma by Scratch2 is required for neuronal survival during embryonic development Rodriguez-Aznar E, Nieto MA Cell Death Differ 2011 18(7):1196 https://doi.org/10.1038/cdd.2010.190
Thanatophoric Dysplasia Type II With Encephalocele and Semilobar Holoprosencephaly: Insights Into Its Pathogenesis Martinez-Frias ML, Egues X, Puras A, Hualde J, De Frutos CA, Bermejo E, Nieto MA, Martinez S Am J Med Genet A 2011 155A(1):197 https://doi.org/10.1002/ajmg.a.33765
The ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease Nieto MA Annu Rev Cell Dev Biol 2011 27:347 https://doi.org/10.1146/annurev-cellbio-092910-154036
Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice Grande MT, Fuentes-Calvo I, Arevalo M, Heredia F, Santos E, Martinez-Salgado C, Rodriguez-Puyol D, Nieto MA, Lopez-Novoa JM, Martinez E Kidney Int 2010 77(6):509 https://doi.org/10.1038/ki.2009.498
Epithelial plasticity, stemness and pluripotency Ocaña OH, Nieto MA Cell Res 2010 20(10):1086 https://doi.org/10.1038/cr.2010.127
Review of the Recently Defined Molecular Mechanisms Underlying Thanatophoric Dysplasia and Their Potential Therapeutic Implications for Achondroplasia Martinez-Frias ML, De Frutos CA, Bermejo E, Nieto MA; ECEMC Working Group Am J Med Genet A 2010 152A(1):245 https://doi.org/10.1002/ajmg.a.33188
Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes Franco DL, Mainez J, Vega S, Sancho P, Murillo MM, De Frutos CA, Del Castillo G, Lopez-Blau C, Fabregat I, Nieto MA J Cell Sci 2010 123(20):3467 https://doi.org/10.1242/jcs.068692

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