Personal
Ana Carmena de la Cruz
Jefe de grupo
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División asimétrica de células madre neurales en desarrollo y tumorogénesis
https://in.umh-csic.es/grupo3883
- Drosophila neural stem cell division and human tumorigenesis: fail to divide (asymmetrically) and tumors…will conquer?. Carmena A. Front. Cell Dev. Biol. 2026 14: 1866713 https://doi.org/10.3389/fcell.2026.1866713
- Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells. Maribel Franco, Ricardo Gargini, Víctor M Barberá, Daniel Becerra, Miguel Saceda, Ana Carmena eLife. 2025 14: RP105690 https://doi.org/10.7554/eLife.105690.3
- Latest News from the “Guardian”: p53 Directly Activates Asymmetric Stem Cell Division Regulators. Ana Carmena. Int. J. Mol. Sci. 2025 26(7): 3171 (Special Issue p53: Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell) https://doi.org/10.3390/ijms26073171
- Drosophila p53 tumor suppressor directly activates conserved asymmetric stem cell division regulators. Sandra Manzanero-Ortiz, Maribel Franco, Mahima Laxmeesha, Ana Carmena iScience. 2024 Volume 27, Issue 11 - Open access https://doi.org/10.1016/j.isci.2024.111118
- Glial-secreted Netrins regulate Robo1/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem and progenitor cell division. Ana de Torres-Jurado, Sandra Manzanero-Ortiz, Ana Carmena Current Biology. 2022 32(10): 2174-2188.e3 https://doi.org/10.1016/j.cub.2022.04.001
- Non-muscle myosin II activation: adding a classical touch to ROCK Carmena A Small GTPases 2021 12(3):161 https://doi.org/10.1080/21541248.2019.1671148
- Pilot RNAi Screen in Drosophila Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division Manzanero-Ortiz S, de Torres-Jurado A, Hernández-Rojas R, Carmena A Int J Mol Sci 2021 22(21):11332 https://doi.org/10.3390/ijms222111332
- The Case of the Scribble Polarity Module in Asymmetric Neuroblast Division in Development and Tumorigenesis Carmena A Int J Mol Sci 2020 21(8):2865 https://doi.org/10.3390/ijms21082865
- Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells Franco M, Carmena A Journal of Cell Biology 2019 218(4):1200 https://doi.org/10.1083/jcb.201807157
- Eph signaling in mitotic spindle orientation: whats your angle here? Franco M, Carmena A Cell Cycle 2019 18(20):2590 https://doi.org/10.1080/15384101.2019.1658479
- Measurement of Mitotic Spindle Angle and Mitotic Cell Distance in Fixed Tissue of Drosophila Larval Brains Franco M, Carmena A Small GTPases 2019 9(22):e3432 https://doi.org/10.21769/BioProtoc.3432
- Non-muscle myosin II activation: adding a classical touch to ROCK Carmena A J Neurosci Methods 2019 12(3):161 https://doi.org/10.1080/21541248.2019.1671148
- Compromising asymmetric stem cell division in Drosophila central brain: revisiting the connections with tumorigenesis Carmena A Fly 2018 12(1):71 https://doi.org/10.1080/19336934.2017.1416277
- Synergism between canoe and scribble mutations causes tumorlike overgrowth via Ras activation in neural stem cells and epithelia Rives-Quinto N, Franco M, de Torres-Jurado A, Carmena A Development 2017 144(14):2570 https://doi.org/10.1242/dev.148171
- The Hippo Pathway Core Cassette Regulates Asymmetric Cell Division Keder A, Rives-Quinto N, Aerne BL, Franco M, Tapon N, Carmena A Curr Biol 2015 25(21):2739 https://doi.org/10.1016/j.cub.2015.08.064
- A Serrate-Notch-Canoe complex mediates glial-neuroepithelial cell interactions essential during Drosophila optic lobe development, Perez-Gomez R, Slovakova J, Rives-Quinto N, Krejci A, Carmena A J Cell Sci 2013 126(21):4873 https://doi.org/10.1242/jcs.125617
- Cytoplasmic protein motility and polarized sorting during asymmetric cell division Keder A, Carmena A Wiley Interdiscip Rev Dev Biol 2013 2(6):797 https://doi.org/10.1002/wdev.116
- A big new job for small GTPases Carmena A Small Gtpases 2012 3(3):159 https://doi.org/10.4161/sgtp.19631
- The Actin-Binding Protein Canoe/AF-6 Forms a Complex with Robo and Is Required for Slit-Robo Signaling during Axon Pathfinding at the CNS Midline Slovakova J, Speicher S, Sanchez-Soriano N, Prokop A, Carmena A J Neurosci 2012 32(29):10035 https://doi.org/10.1523/JNEUROSCI.6342-11.2012
- Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions Slovakova J, Carmena A Development 2011 138(8):1563 https://doi.org/10.1242/dev.056192
- The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation Carmena A, Makarova A, Speicher S J Cell Biol 2011 195(4):553 https://doi.org/10.1083/jcb.201108112
Ana Carmena de la Cruz