Neuromodulación Sináptica

Líneas de investigación

Después de un intensivo período de refinamiento durante el desarrollo, el cerebro adulto mantiene la capacidad de adaptarse rápidamente en respuesta a los cambios externos gracias a un proceso celular conocido como plasticidad sináptica. El objetivo de nuestro grupo de investigación es el de comprender los mecanismos de regulación de la plasticidad sináptica en circuitos neuronales específicos, e identificar como la alteración de estos procesos puede generar enfermedades psiquiátricas y neurodegenerativas. En particular, nuestro laboratorio está centrado en identificar circuitos susceptibles durante los períodos tempranos de neurodegeneración mediante el uso de técnicas virales adaptadas para el mapeo de redes neuronales. Además estamos interesados en estudiar cómo se regula la secreción de neuromoduladores como las catecolaminas y neuropéptidos endógenos que modulan la plasticidad sináptica y el comportamiento. Otro objetivo de nuestro grupo es el de desarrollar nuevas estrategias moleculares destinadas al control de la señalización y función neuronales. En la actualidad estamos experimentando con moléculas foto-activables para manipular el tráfico vesicular en modelos in vitro e in vivo.

Publicaciones relevantes

Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain Madrigal MdP, Jurado S Commun Biol 2021 4(1):586 https://doi.org/10.1038/s42003-021-02110-4
Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms Kristin L Arendt , Yingsha Zhang , Sandra Jurado , Robert C Malenka , Thomas C Südhof , Lu Chen Neuron 2015 86(2):442 https://doi.org/10.1016/j.neuron.2015.03.009
Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression Taulant Bacaj, Mohiuddin Ahmad, Sandra Jurado, Robert C. Malenka and Thomas C. Südhof J Neuroscience 2015 35 (19) 7460 https://doi.org/10.1523/JNEUROSCI.1581-14.2015
Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens Schwartz N,Temkin P, Jurado S, Lim BK, Polepalli JS, Malenka RC. Science 2014 345(6196):535 https://doi.org/10.1126/science.1253994
LTP requires a unique postsynaptic SNARE fusion machinery. Jurado S, Goswami D, Zhang Y, Molina AJ, Südhof TC, Malenka RC. Neuron 2013 77(3):542 https://doi.org/10.1016/j.neuron.2012.11.029

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