Lines of investigation
After the intensive refinement process that occurs during the developmental stages, the mature brain retains the ability of undergoing rapid adaptations in response to external stimuli by the means of a cellular phenomenon known as synaptic plasticity. Our goal is to understand how synaptic plasticity is regulated in discrete neural circuits, and how alterations of this process can lead to neurodegenerative and neuropsychiatric diseases. In particular, our laboratory is currently identifying susceptible circuits during early stages of neurodegeneration by using viral-based circuit mapping techniques. We are also interested in understanding how critical neuromodulators such as cathecolamines and endogenous neuropeptides are secreted and how their exocytosis impacts synaptic plasticity and ultimately behavior. To improve the resolution of our molecular studies and manipulations, we plan to develop novel tools to regulate neuronal signaling and function. In particular, we are interested in exploring photo-activatable molecules to control vesicle dynamics in in vivo and in vitro models.
- Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain Madrigal MdP, Jurado S Commun Biol 2021 4(1):586 https://doi.org/10.1038/s42003-021-02110-4
- Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms Kristin L Arendt , Yingsha Zhang , Sandra Jurado , Robert C Malenka , Thomas C Südhof , Lu Chen Neuron 2015 86(2):442 https://doi.org/10.1016/j.neuron.2015.03.009
- Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression Taulant Bacaj, Mohiuddin Ahmad, Sandra Jurado, Robert C. Malenka and Thomas C. Südhof J Neuroscience 2015 35 (19) 7460 https://doi.org/10.1523/JNEUROSCI.1581-14.2015
- Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens Schwartz N,Temkin P, Jurado S, Lim BK, Polepalli JS, Malenka RC. Science 2014 345(6196):535 https://doi.org/10.1126/science.1253994
- LTP requires a unique postsynaptic SNARE fusion machinery. Jurado S, Goswami D, Zhang Y, Molina AJ, Südhof TC, Malenka RC. Neuron 2013 77(3):542 https://doi.org/10.1016/j.neuron.2012.11.029