Personal
Francisco J. Tejedor Rescalvo
Francisco J Tejedor studied Chemistry at the University of Granada (Spain) and made a Master Thesis on novel photosynthetic methods (1979). He made his PhD working on the regulation of protein synthesis and inhibitory mechanisms of antibiotics at the Centro de Biologia Molecular-Severo Ochoa, CSIC-Universidad Autonoma de Madrid (1979-83), where he also hold a Teaching Assistant position ((1980-85). He was NATO postdoc fellow at the Dept. of Pharmacology University of Washington, Seatle, USA (1985-88) where he worked on structure function relationship of voltage gated ion channels. As an EMBO postdoc fellow, he moved to the Lehrstuhl für Biochemie, Ruhr-Universität-Bochum, Germany, (1988-89) where investigated molecular mechanisms of ion channels regulation. In 1990, he got a Staff Scientist CSIC position at the Instituto Cajal- CSIC (Madrid) where he started his own research group and, in collaborations with other labs, cloned and characterized by first time the Mnb/Dyrk1A gene. In 1996, he moved to Alicante where he organized the Department of Developmental Neurobiology of the Instituto de Neurociencias as a joint center of the C.S.I.C. and the Universidad Miguel Hernandez. Along these years his Molecular Neurogenetics Group has been working on the genetic, cellular and molecular basis of neural proliferation and neurogenesis during brain development and associated neurodevelopmental pathologies. His work has extensively contributed to the understanding of the neurodevelopmental functions of the Down syndrome candidate gene DYRK1A.
Investigador Científico CSIC
- Neurogenética Molecular (URL: https://in.umh-csic.es/grupo3899)
- A novel proneural function of Asense is integrated with the sequential actions of Delta-Notch, L’sc and Su(H) to promote the neuroepithelial to neuroblast transition. Mercedes Martin,Francisco Gutierrez-Avino,Mirja N. Shaikh,Francisco J. Tejedor PLos Genet. 2023 19(10): e1010991 https://doi.org/10.1371/journal.pgen.1010991
- Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease. Viard , Yann Loe-Mie, Rachel Daudin , Malik Khelfaoui , Christine Plancon, Anne Boland, Tejedor FJ et al. Life Sci Alliance . 2022 5 (12) : art e202101205 https://doi.org/10.26508/lsa.202101205
- Mnb/Dyrk1A orchestrates a transcriptional network at the transition from self-renewing neurogenic progenitors to postmitotic neuronal precursors Shaikh MN, Tejedor FJ J Neurogen 2018 32(1):37 https://doi.org/10.1080/01677063.2018.1438427
- Minibrain drives the Dacapo-dependent cell cycle exit of neurons in the Drosophila brain by promoting asense and prospero expression Shaikh MN, Gutierrez-Aviño F, Colonques J, Ceron J, Hämmerle B, Tejedor FJ Development 2016 143(17):3195 https://doi.org/10.1242/dev.134338
- DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies Becker W, Soppa U, Tejedor FJ CNS Neurol Disord-Drug Targets 2014 13(1):26
- The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation Soppa U, Schumacher J, Florencio V, Pasqualon T, Tejedor FJ, Becker W Cell Cycle 2014 13(13):2084 https://doi.org/10.4161/cc.29104
- A Transient Expression of Prospero Promotes Cell Cycle Exit of Drosophila Postembryonic Neurons through the Regulation of Dacapo Colonques J, Ceron J, Reichert H, Tejedor FJ PLoS ONE 2011 6(4):e19342 https://doi.org/10.1371/journal.pone.0019342
- MNB/DYRK1A as a multiple regulator of neuronal development Tejedor FJ, Hammerle B FEBS J 2011 278(2):223 https://doi.org/10.1111/j.1742-4658.2010.07954.x
- Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27(KIP1) expression and suppressing NOTCH signaling Hammerle B, Ulin E, Guimera J, Becker W, Guillemot F, Tejedor FJ Development 2011 138(12):2543 https://doi.org/10.1242/dev.066167
- Local translation of dendritic RhoA revealed by an improved synaptoneurosome preparation Troca-Marin JA, Alves-Sampaio A, Tejedor FJ, Montesinos ML Mol Cell Neurosci 2010 43(3):308 https://doi.org/10.1016/j.mcn.2009.12.004