Lines of investigation
Neuroinflammation and neurodegeneration are hot topics in brain research, and they have become very promising targets for the development of novel disease-modifying treatments in pathological conditions. In order to characterize there aspects of brain tissue in both preclinical and human models, non-invasive tools are needed to measure biomarkers of the inflammatory state and salient microstructural characteristics, such as the level of myelination, axonal diameter and density.
Our research focuses on the development, optimization and application of innovative, non-invasive and translational resonance imaging tools, relevant to both basic and clinical research. The objective is to characterize such biomarkers throughout life, with special attention to healthy aging, as well as identify early biomarkers, which can precede and predict diseases such as multiple sclerosis and Alzheimer’s, all taking into account the gender dimension. An additional line of research is dedicated to developing computational approaches based on machine learning so that the developed methodologies can be optimally transferred to the clinic.
- Mapping microglia and astrocyte activation in vivo using diffusion MRI Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena , Mark Drakesmith2, Kristin Koller, Derek K Jones , Santiago Canals , Silvia De Santis Sci Adv. 2022 8(21):eabq2923 https://doi.org/10.1126/sciadv.abq2923
- Multishell diffusion imaging reveals sex-specific trajectories of early white matter degeneration in normal aging Toschi N, Gisbert RA, Passamonti L, Canals S, De Santis S Neurobiol Aging 2020 86:191 https://doi.org/10.1016/j.neurobiolaging.2019.11.014
- Evidence of early microstructural white matter abnormalities in multiple sclerosis from multi-shell diffusion MRI De Santis S, Granberg T, Ouellette R, Treaba CA, Herranz E, Fan Q, Mainero C, Toschi N Neuroimage Clin 2019 22:101699 https://doi.org/10.1016/j.nicl.2019.101699
- Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence De Santis S, Bach P, Pérez-Cervera L, Cosa-Linan A, Weil G, Vollstädt-Klein S, Hermann D, Kiefer F, Kirsch P, Ciccocioppo R, Sommer WH, Canals S JAMA Psychiatry 2019 76(7):749 https://doi.org/10.1001/jamapsychiatry.2019.0318