Personal
Santiago Canals Gamoneda

Group

• Plasticity of Brain Networks
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Programs

• Human cognition & behaviour

Projects

• PROMETEO – WHITE MATTER IN ALCOHOL USE DISORDERS: A NEW TARGET OF THE GUT-BRAIN AXIS
• Actualización de la Base de Memoria del Cerebro: Perspectiva Experimental
• Interferencia Temporal y Neuromodulación Aumentada por Gemelos Digitales para Mejorar la Formación de Memoria: perspectiva experimental.
• Gemelos digitales del cerebro: una herramienta IA para localizar focos epilépticos.
• The European University of Brain and Technology (NeurotechEU)
• Inflamed Brain Response in Alcohol Addiction: Understanding the role of neuroinflammation, immunotypes and gut-brain reactivity for heterogeneity in disease course and therapy response
• AppZheimer: Una herramienta para monitorizar a gran escala el deterior cognitivo y su aplicación para el diagnóstico temprano del alzhéimer

Articles

• Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer’s Disease. Martínez-Tazo P, Mejias-Ortega M, López-López V, Bhojwani-Cabrera AM, Saxton E, Canals S, Hardingham G, Gutierrez A, Lopez-Atalaya JP, De Santis S. Eur J Neurosci. 2026 63, no. 9: e70536 https://doi.org/10.1111/ejn.70536
• Alcohol-Induced Changes in Brain Microstructure: Uncovering Novel Pathophysiological Mechanisms of AUD Using Translational DTI in Humans and Rodents. Wolfgang H Sommer , Santiago Canals. Curr Top Behav Neurosci. 2025 72: 595-617 https://doi.org/10.1007/7854_2025_585
• NAc-DBS selectively enhances memory updating without effect on retrieval. Andrés Pérez-Segura, Jorge Medina, Antonio Cerdán Cerdá, Cristina Sánchez-Ferri, Daniel Torres, Claudio R. Mirasso, Bryan Strange, Víctor M. Eguíluz, Lucas Lacasa & Santiago Canals. Neuropsychopharmacology. 2025 50: 1420–1429 https://doi.org/10.1038/s41386-025-02132-0
• Protocol to study brain dynamics of mammals through the hierarchy of complex correlation patterns defining a robust functional architecture. Levente Varga , Balázs Péntek, Botond Molnár , Laura Perez-Cervera , Mohamed Kotb Selim , Antonio Díaz-Parra , David Moratal, Wolfgang H. Sommer, Santiago Canals , Raul C. Mureșan, Vasile V. Moca3 , Maria Ercsey-Ravasz. Protocol. 2025 6(2): art. number 103693 https://doi.org/10.1016/j.xpro.2025.103693
• The role of feedforward and feedback inhibition in modulating theta-gamma cross-frequency interactions in neural circuits. Chalkiadakis D, Sánchez-Claros J, López-Madrona VJ, Canals S and Mirasso CR. PLoS Computational Biology. 2025 21(8): e1013363 https://doi.org/10.1371/journal.pcbi.1013363
• Brain dynamics supported by a hierarchy of complex correlation patterns defining a robust functional architecture. Varga L, Moca VV, Molnár B, Perez-Cervera L, Selim MK, Díaz-Parra A, Moratal D, Péntek B, Sommer WH, Muresan RC, Canals S and Ercsey-Ravasz M. Cell Systems. 2024 15(8), 770-786.e5. https://doi.org/10.1016/j.cels.2024.07.003
• How Diet and Lifestyle Can Fine-Tune Gut Microbiomes for Healthy Aging. M. Tamayo, M. Olivares, P. Ruas-Madiedo, A. Margolles, J.C. Espín, I. Medina, M.V. Moreno-Arribas, S. Canals, C.R. Mirasso, S. Ortín, H. Beltrán-Sanchez, A. Pallon, F.A. Tomás-Barberán, and Y. Sanz Annual Review of Food Science and Technology. 2024 15: 283-305 https://doi.org/10.1146/annurev-food-072023-034458
• Influence of temporal information gaps on decision making: describing the dynamics of working memory. Sospedra A, Canals S, Marcos E. bioRxiv. 2024 in press https://doi.org/10.1101/2024.07.17.603868
• Repetitive deep TMS in alcohol dependent patients halts progression of white matter changes in early abstinence. Selim MK, Harel M, De Santis S, Perini I, Sommer W, Heilig M, Zangen A & Canals, S. Psychiatry and Clinical Neurosciences. 2024 78(3): 176-185 https://doi.org/10.1111/pcn.13624
• Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence. Pérez-Cervera L, De Santis S, Marcos E, Ghorbanzad-Ghaziany Z, Trouvé-Carpena A, Kotb Selim M, Pérez-Ramírez U, Pfarr S, Bach P, Halli P, Kiefer F, Moratal D, Kirsch P, Sommer W.H & Canals S. Acta Neuropathol Commun. 2023 11, art. nº 101 ( junio 2023) https://doi.org/10.1186/s40478-023-01597-8
• Chapter: Brain Microstructure in Alcohol Addiction: Characterization of Diffusion-Based MRI Biomarkers, Neuropathological Substrates, and Functional Consequences Silvia De Santis, Mohamed Kotb Selim & Santiago Canals Book. Alcohol and Alcohol-related Diseases. Springer, Cham. 2023 In: Mueller, S., Heilig, M. (eds) pp 493–508 https://doi.org/10.1007/978-3-031-32483-3_27
• Execution of new trajectories toward a stable goal without a functional hippocampus. Adrian J. Duszkiewicz, Janine I. Rossato, Andrea Moreno, Tomonori Takeuchi, Miwako Yamasaki, Lisa Genzel, Patrick Spooner, Santiago Canals, Richard G. M. Morris Hippocampus 2023 33 (6): Special Issue: A New View of Hippocampal Area CA2 ‐ Part 2, pp 769-786 https://doi.org/10.1002/hipo.23497
• MRI texture-based radiomics analysis for the identification of altered functional networks in alcoholic patients and animal models. Ruiz-España, S., Ortiz-Ramón, R., Pérez-Ramírez, Ú., Díaz-Parra, A., Ciccocioppo, R., Bach, P., Vollstädt-Klein, S., Kiefer, F., Sommer, W.H., Canals, S., Moratal, D. Comput Med Imaging Graph. 2023 104: art. 102187 https://doi.org/10.1016/j.compmedimag.2023.102187
• Abnormalities in Cortical GABAergic Interneurons of the Primary Motor Cortex Caused by Lis1 (Pafah1b1) Mutation Produce a Non-drastic Functional Phenotype. Domínguez-Sala E, Valdés-Sánchez L, Canals S, Reiner O, Pombero A, García-López R, Estirado A, Pastor D, Geijo-Barrientos E, Martínez S Front Cell Dev Biol. 2022 10: art 769853 https://doi.org/10.3389/fcell.2022.769853
• Brain Network Allostasis after Chronic Alcohol Drinking Is Characterized by Functional Dedifferentiation and Narrowing. Pérez-Ramírez , López-Madrona , Pérez-Segura , Pallarés , Moreno , Ciccocioppo , Hyytiä , Sommer , Moratal , Canals S J Neurosci . 2022 42 (21): 4401-4413 https://doi.org/10.1523/JNEUROSCI.0389-21.202
• From a systems view to spotting a hidden island: A narrative review implicating insula function in alcoholism. Sommer WH, Canals S, Bifone A, Heilig M, Hyytiä P. Neuropharmacology. 2022 209: art. 108989 - Review https://doi.org/10.1016/j.neuropharm.2022.108989
• Increased network centrality of the anterior insula in early abstinence from alcohol. Bordier C, Weil G, Bach P, Scuppa G, Nicolini C, Forcellini G, Pérez-Ramirez U, Moratal D, Canals S, Hoffmann S, Hermann D, Vollstädt-Klein S, Kiefer F, Kirsch P, Sommer WH, Bifone A Addict Biol. 2022 27(1): e13096 https://doi.org/10.1111/adb.13096
• Libro Blanco Volumen 5: Cerebro, mente y comportamiento. Eloísa Herrera; José Antonio Esteban; Elisa Martí; Juan Ramón Martínez-Morales; Liset Menéndez de la Prida; Ramón Reig; Santiago Canals; Frederic Bartumeus; Esther Serrano Saiz; María Jesús Santesmases; Yolanda Sanz; José P. López-Atalaya; ISBN: 978-84-00-11012-3 - eISBN: 978-84-00-11013-0 - Consejo Superior de Investigaciones Científicas. 2022 Libros Blancos. (Desafíos Científicos del CSIC : Rumbo al 2030 ; vol. 5) http://libros.csic.es/product_info.php?products_id=1616
• Low-Power Lossless Data Compression for Wireless Brain Electrophysiology. Cuevas-López, A., Pérez-Montoyo, E., López-Madrona, V.J., Canals, S., Moratal, D. Sensors (Basel). 2022 22 (10): art. 3676 https://doi.org/10.3390/s22103676
• Mapping microglia and astrocyte activation in vivo using diffusion MRI Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena , Mark Drakesmith2, Kristin Koller, Derek K Jones , Santiago Canals , Silvia De Santis Sci Adv. 2022 8(21):eabq2923 https://doi.org/10.1126/sciadv.abq2923
• Functional Interactions between Entorhinal Cortical Pathways Modulate Theta Activity in the Hippocampus Lopez-Madrona VJ, Canals S Biology (Basel) 2021 10(8):692 https://doi.org/10.3390/biology10080692
• Increased network centrality of the anterior insula in early abstinence from alcohol Bordier C, Weil G, Bach P, Scuppa G, Nicolini C, Forcellini G, Pérez-Ramirez U, Moratal D, Canals S, Hoffmann S, Hermann D, Vollstädt-Klein S, Kiefer F, Kirsch P, Sommer WH, Bifone A Addict Biol 2021 27(1):e13096 https://doi.org/10.1111/adb.13096
• Information Transmission in Delay-Coupled Neuronal Circuits in the Presence of a Relay Population Sánchez-Claros J, Pariz A, Valizadeh A, Canals S, Mirasso CR Front Syst Neurosci 2021 15:705371 https://doi.org/10.3389/fnsys.2021.705371
• Neuroimaging reveals functionally distinct neuronal networks associated with high-level alcohol consumption in two genetic rat models Pallarés V, Dudek M, Moreno A, Pérez-Ramírez Ú, Moratal D, Haaranen M, Ciccocioppo R, Sommer WH, Canals S, Hyytiä P Behav Pharmacol 2021 32(2&3):229 https://doi.org/10.1097/FBP.0000000000000582
• Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain De Santis S, Cosa-Linan A, Garcia-Hernandez R, Dmytrenko L, Vargova L, Vorisek I, Stopponi S, Bach P, Kirsch P, Kiefer F, Ciccocioppo R, Sykova E, Moratal D, Sommer WH, Canals S Sci Adv 2020 6(26):eaba0154 https://doi.org/10.1126/sciadv.aba0154
• Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks López-Madrona VJ, Pérez-Montoyo E, Álvarez-Salvado E, Moratal D, Herreras O, Pereda E, Mirasso CR, Canals S eLife 2020 9:e57313 https://doi.org/10.7554/eLife.57313
• Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone Bach P, Weil G, Pompili E, Hoffmann S, Hermann D, Vollstädt-Klein S, Mann K, Perez-Ramirez U, Moratal D, Canals S, Dursun SM, Greenshaw AJ, Kirsch P, Kiefer F, Sommer WH Addict Biol 2020 25(1):e12717 https://doi.org/10.1111/adb.12717
• KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain Lipinski M, Muñoz-Viana R, Del Blanco B, Marquez-Galera A, Medrano-Relinque J, Caramés JM, Szczepankiewicz AA, Fernandez-Albert J, Navarrón CM, Olivares R, Wilczyński GM, Canals S, Lopez-Atalaya JP, Barco A Nat Commun 2020 11(1):2588 https://doi.org/10.1038/s41467-020-16246-0
• Multishell diffusion imaging reveals sex-specific trajectories of early white matter degeneration in normal aging Toschi N, Gisbert RA, Passamonti L, Canals S, De Santis S Neurobiol Aging 2020 86:191 https://doi.org/10.1016/j.neurobiolaging.2019.11.014
• Detecting Alcohol-Induced Brain Damage Noninvasively Using Diffusion Tensor Imaging De Santis S, Sommer WHx Canals S ACS Chem Neurosci 2019 10(10):4187 https://doi.org/10.1021/acschemneuro.9b00481
• Inferring correlations associated to causal interactions in brain signals using autoregressive models López-Madrona VJ, Matias FS, Mirasso CR, Canals S, Pereda E Scientifc Reports 2019 9(1):17041 https://doi.org/10.1038/s41598-019-53453-2
• Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence De Santis S, Bach P, Pérez-Cervera L, Cosa-Linan A, Weil G, Vollstädt-Klein S, Hermann D, Kiefer F, Kirsch P, Ciccocioppo R, Sommer WH, Canals S JAMA Psychiatry 2019 76(7):749 https://doi.org/10.1001/jamapsychiatry.2019.0318
• Non-invasive MRI windows to neuroinflammation De Santis S, Canals S Neuroscience 2019 403:1 https://doi.org/10.1016/j.neuroscience.2019.01.051
• Radiomicrobiomics: Advancing Along the Gut-brain Axis Through Big Data Analysis De Santis S, Moratal D, Canals S Magn Reson Imaging 2019 403:145 https://doi.org/10.1016/j.neuroscience.2017.11.055
• TherMouseDuino: An affordable Open-Source temperature control system for functional magnetic resonance imaging experimentation with mice Quiñones DR, Fernandez-Molla LM, Pacheco-Torres J, Carames JM, Canals S, Moratal D Magn Reson Imaging 2019 58:67 https://doi.org/10.1016/j.mri.2019.01.009
• A Tangible Educative 3D Printed Atlas of the Rat Brain Quiñones DR, Ferragud-Agullo J, Perez-Feito R, Garcia-Manrique JA, Canals S, Moratal D Materials 2018 11(9):1531 https://doi.org/10.3390/ma11091531
• Alcoholic liver disease: Utility of animal models Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gomez Del Moral M, Martinez-Naves E, Nevzorova YA, Cubero FJ World J Gastroenterol 2018 24(45):5063 https://doi.org/10.3748/wjg.v24.i45.5063
• Finding influential nodes for integration in brain networks using optimal percolation theory Del Ferraro G, Moreno A, Min B, Morone F, Perez-Ramirez U, Peérez-Cervera L, Parra LC, Holodny A, Canals S, Makse HA Nat Commun 2018 9(1):2274 https://doi.org/10.1038/s41467-018-04718
• Functional MRI of Synaptic Plasticity Pacheco-Torres, Jesus; Moreno, Andrea; Fernandez, Begona; Perez-Cervera, Laura; Maria Carames, Jose; Miguel Fernandez-Molla, Luis; Perez-Montoyo, Elena; Martinez-Sanchez, Miriam; Moratal, David; Canals, Santiago HANDBOOK OF IN VIVO NEURAL PLASTICITY TECHNIQUES: A SYSTEMS NEUROSCIENCE APPROACH TO THE NEURAL BASIS OF MEMORY AND COGNITION 2018 28:441 https://doi.org/10.1016/B978-0-12-812028-6.00024-0
• High frequency neurons determine effective connectivity in neuronal networks Pariz A, Esfahani ZG, Parsi SS, Valizadeh A, Canals S, Mirasso CR Neuroimage 2018 166:349 https://doi.org/10.1016/j.neuroimage.2017.11.014
• Mapping Functional Connectivity in the Rodent Brain Using Electric-Stimulation fMRI Perez-Cervera L, Carames JM, Fernandez-Molla LM, Moreno A, Fernandez B, Perez-Montoyo E, Moratal D, Canals S, Pacheco-Torres J Methods Mol Biol 2018 1718:117 https://doi.org/10.1007/978-1-4939-7531-0_8
• Silent Learning Rossato JI, Moreno A, Genzel L, Yamasaki M, Takeuchi T, Canals S, Morris RGM Curr Biol 2018 28(21):3508 https://doi.org/10.1016/j.cub.2018.09.012
• Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study Lucia FS, Pacheco-Torres J, González-Granero S, Canals S, Obregón MJ, García-Verdugo JM, Berbel P Front Neuroanat 2018 12:31 https://doi.org/10.3389/fnana.2018.00031
• Multi-modal MRI classifiers identify excessive alcohol consumption and treatment effects in the brain Cosa A, Moreno A, Pacheco-Torres J, Ciccocioppo R, Hyytiä P, Sommer WH, Moratal D, Canals S Addict Biol 2017 22(5):1459 https://doi.org/10.1111/adb.12418
• On the role of the entorhinal cortex in the effective connectivity of the hippocampal formation Lopez-Madrona VJ, Matias FS, Pereda E, Canals S, Mirasso CR Chaos 2017 27(4):47401 https://doi.org/10.1063/1.4979001
• Structural and functional, empirical and modeled connectivity in the cerebral cortex of the rat Diaz-Parra A, Osborn Z, Canals S, Moratal D, Sporns O Neuroimage 2017 159:170 https://doi.org/10.1016/j.neuroimage.2017.07.046
• Frequency-Dependent Gating of Hippocampal-Neocortical Interactions Moreno A, Morris RGM, Canals S Cereb Cortex 2016 26(5):2105 https://doi.org/10.1093/cercor/bhv033
• Modulation of nucleus accumbens connectivity by alcohol drinking and naltrexone in alcohol-preferring rats: A manganese-enhanced magnetic resonance imaging study Dudek M, Canals S, Sommer WH, Hyytiä P Eur Neuropsychopharmacol 2016 26(3):445 https://doi.org/10.1016/j.euroneuro.2016.01.003
• Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens Hadar R, Vengeliene V, Barroeta Hlusicke E, Canals S, Noori HR, Wieske F, Rummel J, Harnack D, Heinz A, Spanagel R, Winter C Transl Psychiatr 2016 6:e840 https://doi.org/10.1038/tp.2016.100
• Tuning noninvasive brain stimulation with MRI to cope with intersubject variability Habich A, Canals S, Klöppel S Curr Opin Neurol 2016 29(4):453 https://doi.org/10.1097/WCO.0000000000000353
• Adult Newborn Neurons Are Involved in Learning Acquisition and Long-Term Memory Formation: The Distinct Demands on Temporal Neurogenesis of Different Cognitive Tasks Suarez-Pereira I, Canals S, Carrion AM Hippocampus 2015 25(1):51 https://doi.org/10.1002/hipo.22349
• Brain activation induced by voluntary alcohol and saccharin drinking in rats assessed with manganese-enhanced magnetic resonance imaging Dudek M, Abo-Ramadan U, Hermann D, Brown M, Canals S, Sommer WH, Hyytia P Addict Biol 2015 20(6):1012 https://doi.org/10.1111/adb.12179
• Brain size regulations by cbp haploinsufficiency evaluated by in-vivo MRI based volumetry Ateca-Cabarga JC, Cosa A, Pallares V, Lopez-Atalaya JP, Barco A, Canals S, Moratal D Sci Rep 2015 5:16256 https://doi.org/10.1038/srep16256
• Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features Aller MI, Pecoraro V, Paternain AV, Canals S, Lerma J J Neurosci 2015 35(40):13619 https://doi.org/10.1523/JNEUROSCI.2217-15.2015
• Neurosurgery planning in rodents using a magnetic resonance imaging assisted framework to target experimentally defined networks Pallares V, Moya J, Samper-Belda FJ, Canals S, Moratal D Comput Meth Programs Biomed 2015 121(2):66 https://doi.org/10.1016/j.cmpb.7015.05.011
• Widespread Vestibular Activation of the Rodent Cortex Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW J Neurosci 2015 35(15):5926 https://doi.org/10.1523/JNEUROSCI.1869-14.2015
• Avoiding catastrophic failure in correlated networks of networks Reis S, Hu Y, Babino A, Andrade JA, Canals S, Sigman M, Makse H Nat Phys 2014 10(10):762 https://doi.org/10.1038/NPHYS3081
• Functional MRI in mice lacking IP3-dependent calcium signaling in astrocytes Jego P, Pacheco-Torres J, Araque A, Canals S J Cereb Blood F Met 2014 34(10):1599 https://doi.org/10.1038/jcbfm.2014.144
• Functional MRI of long-term potentiation: imaging network plasticity Alvarez-Salvado E, Pallares V, Moreno A, Canals S Philos Trans R Soc B-Biol Sci 2014 369 (1633) https://doi.org/10.1098/rstb.2013.0152
• Phenotyping the central nervous system of the embryonic mouse by magnetic resonance microscopy Martinez-Martinez MA, Pacheco-Torres J, Borrell V, Canals S NeuroImage 2014 97:95 https://doi.org/10.1016/j.neuroimage.2014.04.043
• Amelioration of ischemic brain damage by peritoneal dialysis, Godino MC, Romera VG, Sanchez-Tomero JA, Pacheco J, Canals S, Lerma J, Vivancos J, Moro MA, Torres M, Lizasoain I, Sanchez-Prieto J J Clin Invest 2013 123(10):4359 https://doi.org/10.1172/JCI67284
• Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes Del Pino I, Garcia-Frigola C, Dehorter N, Brotons-Mas JR, Alvarez-Salvado E, Martinez de Lagran M, Ciceri G, Gabaldon MV, Moratal D, Dierssen M, Canals S, Marin O, Rico B Neuron 2013 79(6):1152 https://doi.org/10.1016/j.neuron.2013.07.010
• Neurophysiological, metabolic and cellular compartments that drive neurovascular coupling and neuroimaging signals Moreno A, Jego P, de la Cruz F, Canals S Front Neuroenergetics 2013 5:3 https://doi.org/10.3389/fnene.2013.00003
• Biocytin-Derived MRI Contrast Agent for Longitudinal Brain Connectivity Studies Mishra A, Schuz A, Engelmann J, Beyerlein M, Logothetis NK, Canals S ACS Chem Neurosci 2011 2(10):578 https://doi.org/10.1021/cn200022m

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