Personal
Angel L. Barco Guerrero

Group

• Transcriptional and epigenetic mechanisms of neuronal plasticity
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Programs

• Genetic & epigenetic basis of Individuality & aging
• Neural stem cell regulation and differentiation

Projects

• CENTROS DE EXCELENCIA SEVERO OCHOA 2022/2026
• Plasticity mechanisms enabling complex brain functions
• Mecanismos transcripcionales e interacciones moleculares que subyacen a la robustez y especificidad de la expresión génica neuronal dependiente de actividad
• Ayudas del Programa Santiago Grisolía para la Promoción de la Investigación Científica, Desarrollo Tecnológico y la Innovación en la Comunitat Valenciana.
• Epigenetic Basis of Gene-Environment Interactions Underlying Variation in cognitive Capabilities and Their Decline with Age

Articles

• Sex-dependent interferon signaling contributes to female-biased vulnerability in Alzheimer’s disease. López-López V, Iniesta G, Galán-Ganga M, Expósito-Coca A, Durán-Laforet V, Bhojwani-Cabrera AM, Navarron CM, Guillot-Fernández M, Venero JL, Sánchez-Mut JV, Barco A, Giralt A, López-Atalaya JP. J Neuroinflammation. 2026 23, 217 https://doi.org/10.1186/s12974-026-03840-0
• Cooperative control of neuron-specific repressive chromatin states by intellectual-disability-linked KDM1A and KDM5C demethylases. Martín-González AM, Paraíso-Luna J, Niñerola S, Del Blanco B, Robles RM, Herrera ML, Muñoz-Viana R, Geijo-Barrientos E and Barco A. Cell Reports. 2025 44, 116201 https://doi.org/10.1016/j.celrep.2025.116201
• FrozONE: Quick Cell Nucleus Enrichment for Comprehensive Proteomic Analysis of Frozen Tissues. Huschet, LA, Kliem FP, Wienand P, Wunderlich C, Ribeiro A, Bustos-Martínez I, Barco A, Wunderlich FT, Lech M, Robles MS. Life Sci Alliance. 2025 8(3): e2024031301 https://doi.org/10.26508/lsa.202403130
• Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions. Alaiz-Noya M, Miozzo F, Fuentes-Ramos M, Machnicka MA, Kurowska M, Herrera ML, Del Blanco B, Ninerola S, Bustos-Martínez I, Wilczynski B and Barco A. Nature Communications. 2025 16: 9710 https://doi.org/10.1038/s41467-025-65343-5
• Kdm1a safeguards the topological boundaries of PRC2-repressed genes and prevents aging-related euchromatinization in neurons. Del Blanco B, Niñerola S, Martín-González AM, Paraíso-Luna J, Kim M, Muñoz-Viana R, Racovac C, Sánchez-Mut JV, Ruan Y and Barco A. Nature Communications. 2024 15, 1781 (2024) https://www.nature.com/articles/s41467-024-45773-3
• Keep calm and carry H3K27me1 off. Alcalá-Vida R, Barco A. Neuron 2024 112(17): 2829-2832 https://doi.org/10.1016/j.neuron.2024.07.014
• New Genome-wide Technologies to Study Activity-regulated Transcription. Niñerola S., Barco A. Chapter in “Regulation of transcription by neuronal activity: To the nucleus and back. 2nd Edition” 2024 (Springer Science Publishers). Pag: 561-591
• Targeting epigenetic dysregulation in autism spectrum disorders. Macarena L. Herrera, Juan Paraíso-Luna , Isabel Bustos-Martínez, Ángel Barco. Trends in Molecular Medicine. 2024 30(11): p1028-1046 https://doi.org/10.1016/j.molmed.2024.06.004
• Unveiling Transcriptional and Epigenetic Mechanisms Within Engram Cells: Insights into Memory Formation and Stability. Fuentes-Ramos M., Barco A. Adv Neurobiol. 2024 38: 111-129 - Chapter in “Memory Engrams” (Springer Science Publishers) https://doi.org/10.1007/978-3-031-62983-9_7
• Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance. Irmina Garcia‐Carpio, Vincent Z Braun, Elias S Weiler, Marina Leone , Sergio Niñerola, Angel Barco, Luca L Fava, Andreas Villunger. EMBO J. 2023 42: e113510 https://doi.org/10.15252/embj.2023113510
• CBP and p300 Jointly Maintain Neural Progenitor Viability but Play Unique Roles in the Differentiation of Neural Lineages. González-Martínez, R., Márquez-Galera, A., Del Blanco, B., López-Atalaya, J.P., Barco, A., Herrera, E. Cells 2022 11(24): 4118 https://doi.org/10.3390/cells11244118
• CBP is required for establishing adaptive gene programs in the adult mouse brain. Lipinski, M., Niñerola, S., Fuentes-Ramos, M., Valor, L.M., del Blanco, B., López-Atalaya, J.P., Barco, A. J Neurosci. 2022 42(42): 7984-8001 https://doi.org/10.1523/JNEUROSCI.0970-22.2022
• Multiomic Analysis of Neurons with Divergent Projection Patterns Identifies Novel Regulators of Axon Pathfinding Fernández-Nogales, M., López-Cascales, M.T., Murcia-Belmonte, V., Escalante, A., Fernández-Albert, J., Muñoz-Viana, R., Barco, A., Herrera, E. Advanced Science 2022 9 (29): art. 2200615 https://doi.org/10.1002/advs.202200615
• Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, Rabaneda LG, García-Lira C, Grand T, Briz V, Velasco ER, Andero R, Niñerola S, Barco A, Paoletti P, Wesseling JF, Gardoni F, Tavalin SJ, Perez-Otaño I eLife 2021 10:e71575 https://doi.org/10.7554/eLife.71575
• Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis Cid E, Marquez-Galera A, Valero M, Gal B, Medeiros DC, Navarron CM, Ballesteros-Esteban L, Reig-Viader R, Morales AV, Fernandez-Lamo I, Gomez-Dominguez D, Sato M, Hayashi Y, Bayés À, Barco A, Lopez-Atalaya JP, de la Prida LM Cell Rep 2021 35(10):109229 https://doi.org/10.1016/j.celrep.2021.109229
• Transcriptome and epigenome analysis of engram cells: Next-generation sequencing technologies in memory research Fuentes-Ramos M, Alaiz-Noya M, Barco A Neurosci Biobehav Rev 2021 127:865 https://doi.org/10.1016/j.neubiorev.2021.06.010
• A Zic2-regulated switch in a noncanonical Wnt/betacatenin pathway is essential for the formation of bilateral circuits Morenilla-Palao C, López-Cascales MT, López-Atalaya JP, Baeza D, Calvo-Díaz L, Barco A, Herrera E Sci Adv 2020 6(46):eaaz8797 https://doi.org/10.1126/sciadv.aaz8797
• KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain Lipinski M, Muñoz-Viana R, Del Blanco B, Marquez-Galera A, Medrano-Relinque J, Caramés JM, Szczepankiewicz AA, Fernandez-Albert J, Navarrón CM, Olivares R, Wilczyński GM, Canals S, Lopez-Atalaya JP, Barco A Nat Commun 2020 11(1):2588 https://doi.org/10.1038/s41467-020-16246-0
• Transcriptome Analysis of iPSC-Derived Neurons from Rubinstein-Taybi Patients Reveals Deficits in Neuronal Differentiation Calzari L, Barcella M, Alari V, Braga D, Muñoz-Viana R, Barlassina C, Finelli P, Gervasini C, Barco A, Russo S, Larizza L Mol Neurobiol 2020 57(9):3685 https://doi.org/10.1007/s12035-020-01983-6
• CBP and SRF co-regulate dendritic growth and synaptic maturation Del Blanco B, Guiretti D, Tomasoni R, Lopez-Cascales MT, Muñoz-Viana R, Lipinski M, Scandaglia M, Coca Y, Olivares R, Valor LM, Herrera E, Barco A Cell Death & Differentiation 2019 26(11):2208 https://doi.org/10.1038/s41418-019-0285-x
• Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models Hutson TH, Kathe C, Palmisano I, Bartholdi K, Hervera A, De Virgiliis F, McLachlan E, Zhou L, Kong G, Barraud Q, Danzi MC, Medrano-Fernandez A, Lopez-Atalaya JP, Boutillier AL, Sinha SH, Singh AK, Chaturbedy P, Moon LDF, Kundu TK, Bixby JL, Lemmon VP, Barco A, Courtine G, Di Giovanni S Sci Transl Med 2019 11(487):eaaw2064 https://doi.org/10.1126/scitranslmed.aaw2064
• CBP/p300 in brain development and plasticity: disentangling the KAT’s cradle Lipinski M, Del Blanco B, Barco A Current Opinion in Neurobiology 2019 59:1 https://doi.org/10.1016/j.conb.2019.01.023
• Contribution of spurious transcription to intellectual disability disorders Scandaglia M, Barco A Journal of Medical Genetics 2019 56(8):491 https://doi.org/10.1136/jmedgenet-2018-105668
• Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus Fernandez-Albert J, Lipinski M, Lopez-Cascales MT, Rowley MJ, Martin-Gonzalez AM, Del Blanco B, Corces VG, Barco A Nature Neuroscience 2019 22(10):1718 https://doi.org/10.1038/s41593-019-0476-2
• The Epigenetic Factor CBP Is Required for the Differentiation and Function of Medial Ganglionic Eminence-Derived Interneurons Medrano-Fernandez A, Delgado-Garcia JM, Del Blanco B, Llinares M, Sanchez-Campusano R, Olivares R, Gruart A, Barco A Molecular Neurobiology 2019 56(6):4440 https://doi.org/10.1007/s12035-018-1382-4
• Early alteration of epigenetic-related transcription in Huntington’s disease mouse models Hervas-Corpion I, Guiretti D, Alcaraz-Iborra M, Olivares R, Campos-Caro A, Barco A, Valor LM Sci Rep 2018 8:9925 https://doi.org/10.1038/s41598-018-28185-4
• Editorial on the Special Issue: Molecules and Cognition Barco A, Knafo S Neuroscience 2018 370:1 https://doi.org/10.1016/j.neuroscience.2017.11.003
• Impact of environmental conditions and chemicals on the neuronal epigenome Del Blanco B, Barco A Curr Opin Chem Biol 2018 45:157 https://doi.org/10.1016/j.cbpa.2018.06.003
• CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons Pardo L, Valor LM, Eraso-Pichot A, Barco A, Golbano A, Hardingham GE, Masgrau R, Galea E Sci Rep 2017 7:6390 https://doi.org/10.1038/s41598-017-06231-x
• Epigenetic Etiology of Intellectual Disability Iwase S, Berube NG, Zhou Z, Kasri NN, Battaglioli E, Scandaglia M, Barco A J Neurosci 2017 37(45):10773 https://doi.org/10.1523/JNEUROSCI.1840-17.2017
• Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects Tomasoni R, Morini R, Lopez-Atalaya JP, Corradini I, Canzi A, Rasile M, Mantovani C, Pozzi D, Garlanda C, Mantovani A, Menna E, Barco A, Matteoli M Elife 2017 6:e21735 https://doi.org/10.7554/eLife.21735
• Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons Scandaglia M, Lopez-Atalaya JP, Medrano-Fernandez A, Lopez-Cascales MT, Del Blanco B, Lipinski M, Benito E, Olivares R, Iwase S, Shi Y, Barco A Cell Rep 2017 21(1):47 https://doi.org/10.1016/j.celrep.2017.09.014
• Skill Learning Modulates RNA Pol II Poising at Immediate Early Genes in the Adult Striatum Galvão-Ferreira P, Lipinski M, Santos F, Barco A, Costa RM eNeuro 2017 4(2):UNSP e0074-17.2017 https://doi.org/10.1523/ENEURO.0074-17.2017
• Blocking miRNA Biogenesis in Adult Forebrain Neurons Enhances Seizure Susceptibility, Fear Memory, and Food Intake by Increasing Neuronal Responsiveness Fiorenza A, Lopez-Atalaya JP, Rovira V, Scandaglia M, Geijo-Barrientos E, Barco A Cereb Cortex 2016 26(4):1619 https://doi.org/10.1093/cercor/bhu332
• Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders Medrano-Fernandez A, Barco A Mol Brain 2016 9:83 https://doi.org/10.1186/s13041-016-0263-x
• Role of Dicer and the miRNA system in neuronal plasticity and brain function Fiorenza A, Barco A Neurobiol Learn Mem 2016 135:3 https://doi.org/10.1016/j.nlm.2016.05.001
• Specific promoter deacetylation of histone H3 is conserved across mouse models of Huntington’s disease in the absence of bulk changes Guiretti D, Sempere A, Lopez-Atalaya JP, Ferrer-Montiel A, Barco A, Valor LM Neurobiol Dis 2016 89:190 https://doi.org/10.1016/j.nbd.2016.02.004
• Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury Pardo L, Schlüter A, Valor LM, Barco A, Giralt M, Golbano A, Hidalgo J, Jia P, Zhao Z, Jove M, Portero-Otin M, Ruiz M, Gimenez-Llort L, Masgrau R, Pujol A, Galea E Glia 2016 64(5):853 https://doi.org/10.1002/glia.22969
• Brain size regulations by cbp haploinsufficiency evaluated by in-vivo MRI based volumetry Ateca-Cabarga JC, Cosa A, Pallares V, Lopez-Atalaya JP, Barco A, Canals S, Moratal D Sci Rep 2015 5:16256 https://doi.org/10.1038/srep16256
• Editorial Barco A, Brambilla R, Rosenblum K Neurobiol Learn Mem 2015 124:1 https://doi.org/10.1016/j.nlm.2015.08.001
• Fine-tuned SRF activity controls asymmetrical neuronal outgrowth: implications for cortical migration, neural tissue lamination and circuit assembly Scandaglia M, Benito E, Morenilla-Palao C, Fiorenza F, del Blanco B, Coca Y, Herrera E, Barco A Sci Rep 2015 5:17470 https://doi.org/10.1038/srep17470
• The Neuronal Activity-Driven Transcriptome Benito E, Barco A Mol Neurobiol 2015 51(3):1071 https://doi.org/10.1007/s12035-014-8772-z
• Widespread Vestibular Activation of the Rodent Cortex Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW J Neurosci 2015 35(15):5926 https://doi.org/10.1523/JNEUROSCI.1869-14.2015
• cAMP Responsive Element Binding Protein (CREB) and cAMP Co-regulate Activator Protein 1 (AP1)-Dependent Regeneration-Associated Gene Expression and Neurite Growth Ma TC, Barco A, Ratan RR, Willis DE J Biol Chem 2014 289(47):32914 https://doi.org/10.1074/jbc.M114.582460
• Can changes in histone acetylation contribute to memory formation? Lopez-Atalaya J, Barco A Trends Genet 2014 30(12):529 https://doi.org/10.1016/j.tig.2014.09.003
• Epigenetic factors in intellectual disability: the Rubinstein-Taybi syndrome as a paradigm of neurodevelopmental disorder with epigenetic origin Lopez-Atalaya JP, Valor LM, Barco A Prog Molec Biol Transl Sci 2014 128:139 https://doi.org/10.1016/B978-0-12-800977-2.00006-1
• Histone Acetylation and CREB Binding Protein Are Required for Neuronal Resistance against Ischemic Injury Yildririm F, Ji SB, Kronenberg G, Barco A, Olivares R, Benito E, Dirnangl U, Gertz K, Endres M, Harms C, Meisel A PLoS One 2014 9(4):e95465 https://doi.org/10.1371/journal.pone.0095465
• Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction Ito S, Magalska A, Alcaraz-Iborra M, Lopez-Atalaya JP, Rovira V,Contreras-Moreira B, Lipinski M, Olivares R, Martinez-Hernandez J,Ruszczycki B, Lujan R,Geijo-Barrientos E,Wilczynski GM, Barco A Nat Commun 2014 5:4450 https://doi.org/10.1038/ncomms5450
• Neuroepigenetic disorders: Progress, promises and challenges. Barco A Neuropharmacology 2014 80:1 https://doi.org/10.1016/j.neuropharm.2014.02.013
• Genomic landscape of transcriptional and epigenetic dysregulation in early-onset polyglutamine disease Valor LM, Guiretti D, Lopez-Atalaya JP, Barco A J Neurosci 2013 33(25):10471 https://doi.org/10.1523/JNEUROSCI.0670-13.2013
• Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibiton Lopez-Atalaya JP, Ito S, Valor LM, Benito E, Barco A Nucleic Acids Res 2013 41(17):8072 https://doi.org/10.1093/nar/gkt590
• Histone H3 lysine methylation in cognition and intellectual disability disorders Parkel S, Lopez-Atalaya JP, Barco A Learn Mem 2013 20(10):570 https://doi.org/10.1101/lm.029363.112
• Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders Valor LM, Viosca J, Lopez-Atalaya JP, Barco A Curr Pharm Design 2013 19(28):5051
• Enhanced cAMP Response Element-Binding Protein Activity Increases Neuronal Excitability, Hippocampal Long-Term Potentiation, and Classical Eyeblink Conditioning in Alert Behaving Mice Gruart A, Benito E, Delgado-Garcia JM, Barco A J Neurosci 2012 32(48):17431 https://doi.org/10.1523/JNEUROSCI.4339-12.2012
• Hippocampal gene profiling: Toward a systems biology of the hippocampus Valor LM, Barco A Hippocampus 2012 22(5):929 https://doi.org/10.1002/hipo.20888
• Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome Lopez-Atalaya JP, Gervasini C, Mottadelli F, Spena S, Piccione M, Scarano G, Selicorni A, Barco A, Larizza L J Med Genet 2012 49(1):66 https://doi.org/10.1136/jmedgenet-2011-100354
• Ablation of CBP in Forebrain Principal Neurons Causes Modest Memory and Transcriptional Defects and a Dramatic Reduction of Histone Acetylation But Does Not Affect Cell Viability Valor LM, Pulopulos MM, Jimenez-Minchan M, Olivares R, Lutz B, Barco A J Neurosci 2011 31(5):1652 https://doi.org/10.1523/JNEUROSCI.4737-10.2011
• cAMP Response Element-Binding Protein Is a Primary Hub of Activity-Driven Neuronal Gene Expression Benito E, Valor JM, Jimenez-Minchan M, Huber W, Barco A J Neurosci 2011 31(50):18237 https://doi.org/10.1523/JNEUROSCI.4554-11.2011
• CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement Lopez-Atalaya JP, Ciccarelli A, Viosca J, Valor LM, Jimenez-Minchan M, Canals S, Giustetto M, Barco A EMBO J 2011 30(20):4287 https://doi.org/10.1038/emboj.2011.299
• Genetic Approaches to Investigate the Role of CREB in Neuronal Plasticity and Memory Barco A, Marie H Mol Neurobiol 2011 44(3):330 https://doi.org/10.1007/s12035-011-8209-x
• CREB’s control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models Benito E, Barco A Trends Neurosci 2010 33(5):230 https://doi.org/10.1016/j.tins.2010.02.001
• Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology Viosca J, Lopez-Atalaya JP, Olivares R, Eckner R, Barco A Neurobiol Dis 2010 37(1):186 https://doi.org/10.1016/j.nbd.2009.10.001
• Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function Valor LM, Jancic D, Lujan R, Barco A Cell Death Differ 2010 17(10):1636 https://doi.org/10.1038/cdd.2010.40

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