Lines of investigation
The proper development and connectivity of an adult brain need the extension and guide of neuronal axons to their targets where they will establish appropriate synapses. We are interested in the molecular mechanisms underlying axon guidance and target recognition during the development of the nervous system. We focus on the binary decision of crossing or not the midline that many different types of axons must take at some point of their trajectory and how later they reach their final targets at both sides of the brain and once there, sensory information from both brain hemispheres is integrated and processed. Many features of mature neural function, including the interpretation of sensory information and the coordination of locomotion, depend on coherent communication between the two halves of the nervous system. Therefore, the correct formation of bilateral circuits is essential for the perfect functioning of the mature brain. To understand the mechanisms underlying the development of bilateral circuits our group applies a multidisciplinary set of approaches ranging from mouse genetics, anatomic studies and gene delivery in vivo and in vitro using the mouse visual system as a model.
Representative Publications
-
A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves
Murcia-Belmonte V, Coca Y, Vegar C, Negueruela S, de Juan Romero C, Valiño AJ, Sala S, DaSilva R, Kania A, Borrell V, Martinez LM, Erskine L, Herrera E
Current Biology
2019
29(7):1149
https://doi.org/10.1016/j.cub.2019.02.052
-
The peripheral eye: A neurogenic area with potential to treat retinal pathologies?
Fernandez-Nogales M, Murcia-Belmonte V, Chen HY, Herrera E
Progress in Retinal and Eye Research
2019
68:110
https://doi.org/10.1016/j.preteyeres.2018.09.001
-
The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells
Marcucci F, Murcia-Belmonte V, Wang Q, Coca Y, Ferreiro-Galve S, Kuwajima T, Khalid S, Ross ME, Mason C, Herrera E
Cell Rep
2016
17(12):3153
https://doi.org/10.1016/j.celrep.2016.11.016
-
Zic2-Dependent Axon Midline Avoidance Controls the Formation of Major Ipsilateral Tracts in the CNS
Escalante A, Murillo B, Morenilla-Palao C, Klar A, Herrera E
Neuron
2013
80(6):1392
https://doi.org/10.1016/j.neuron.2013.10.007
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["csic_04"]=>
bool(true)
}
["filter"]=>
NULL
["site_id":"WP_User":private]=>
int(1)
}
}
Doctor Investigador
Doctor Investigador
Doctor Investigador
Doctor Investigador
Doctor Investigador
Predoctor / Support Investigation
Predoctor / Support Investigation
Predoctor / Support Investigation