Personal
Isabel Pérez Otaño
Group leader
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Plasticity and remodeling of neural circuits
https://in.umh-csic.es/group3894
- PROMETEO-MULTISCALE CONTROL OF SYNAPTIC PLASTICITY: ROLES IN NEURAL CIRCUIT FUNCTION AND BEHAVIOR (MULTISYN)
- Sinapsis y Oligodendroglía: Señalización por Receptores NMDA on-convencionales en Comportamiento Adaptativo
- Restoring plasticity of o/igodendrocyte progenitors to foster remyelination in the aged and diseased brain
- GluN3A Is Required for Coordinated Postnatal Development of Axonal and Dendritic Branching Patterns in Mouse L2/3 Callosal Projection Neurons Crawley, O., Corral-Sanchez, B., Navarro, A.I., Marco, S. and Perez-Otaño, I. The Journal of Neuroscience. 2026 46 (25): e0156252026 https://doi.org/10.1523/JNEUROSCI.0156-25.2026
- Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses. Rodriguez Gotor J J, Mahfooz K, Perez-Otano I & Wesseling J F. eLife 2024 12: RP88212 https://doi.org/10.7554/eLife.88212
- Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer’s disease patients. Escamilla S, Badillos R, Comella JX, Solé M, Pérez-Otaño I, Sánchez Mut JV, Sáez-Valero J and Cuchillo-Ibáñez I. Alzheimer's & Dementia 2024 1-15 (in press) https://doi.org/10.1002/alz.14125
- GluN3A subunit tunes NMDA receptor synaptic trafficking and content during postnatal brain development. Gonzalez-Gonzalez, IM, Gray, JA, Ferreira, J., Conde-Dusman, MJ, Bouchet, D., Pérez-Otaño, I *, Groc L. Cell Rep . 2023 42 (5): 112477 https://doi.org/10.1016/j.celrep.2023.112477
- Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder. Staffa, A., Chatterjee, M., Diaz-Tahoces, A., Leroy, F., Perez-Otaño, I. J. Vis. Exp. 2023 e65958 https://doi.org/10.3791/65958
- No evidence for cognitive decline or neurodegeneration in strain-matched Grin3a knockout mice. Remy Verhaeghe, Oscar Elía-Zudaire, Sergio Escamilla, Javier Sáez-Valero, Isabel Pérez-Otaño Alzheimer's & Dementia. 2023 19 (9), pp. 4264 - 4266 https://doi.org/10.1002/alz.13375
- GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits. Bossi, S., Dhanasobhon, D., Ellis-Davies, G.C.R., Frontera, J., de Brito Van Velze, M., Lourenço, J., Murillo, A., Luján, R., Casado, M., Perez-Otaño, I., Bacci, A., Popa, D., Paoletti, P., Rebola, N. Neuron . 2022 110 (15) :2438-2454.e8. https://doi.org/10.1016/j.neuron.2022.05.016
- GluN3A NMDA receptor subunits: more enigmatic than ever?. Crawley O, Conde-Dusman MJ,Perez-Otano I. J Physiol (London). 2022 600(2): 261-276 - Review https://doi.org/10.1113/JP280879
- Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, Rabaneda LG, García-Lira C, Grand T, Briz V, Velasco ER, Andero R, Niñerola S, Barco A, Paoletti P, Wesseling JF, Gardoni F, Tavalin SJ, Perez-Otaño I eLife 2021 10:e71575 https://doi.org/10.7554/eLife.71575
- Temporal Dynamics and Neuronal Specificity of Grin3a Expression in the Mouse Forebrain Murillo A, Navarro AI, Puelles E, Zhang Y, Petros TJ, Pérez-Otaño I Cereb Cortex 2021 31(4):1914 https://doi.org/10.1093/cercor/bhaa330
- Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts Raja MK, Preobraschenski J, Del Olmo-Cabrera S, Martinez-Turrillas R, Jahn R, Perez-Otano I, Wesseling JF eLife 2019 8:e40744 https://doi.org/10.7554/eLife.40744
- Presynaptic NMDARs and astrocytes ally to control circuit-specific information flow Perez-Otano I, Rodriguez-Moreno A Proc Natl Acad Sci USA 2019 116(27):13166 https://doi.org/10.1073/pnas.1908293116
- Sparse force-bearing bridges between neighboring synaptic vesicles Wesseling JF, Phan S, Bushong EA, Siksou L, Marty S, Pérez-Otaño I, Ellisman M Brain Struct Funct 2019 224(9):3263 https://doi.org/10.1007/s00429-019-01966-x
- RNAi-Based GIuN3A Silencing Prevents and Reverses Disease Phenotypes Induced by Mutant huntingtin Marco S, Murillo A, Pérez-Otaño I Mol Ther 2018 26(8):1965 https://doi.org/10.1016/j.ymthe.2018.05.013
- Emerging roles of GluN3-containing NMDA receptors in the CNS Perez-Otaño I, Larsen RS, Wesseling JF Nat Rev Neurosci 2016 17(10):623 https://doi.org/10.1038/nrn.2016.92
- GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling Maria Fiuza, Immaculada González-González, and Isabel Pérez-Otaño PNAS 2013 110(51): 20807 https://doi.org/10.1073/pnas.1312211110
Isabel Pérez Otaño