Personal
Felix Leroy

Group

• Cognition and social interactions (URL: https://in.umh-csic.es/group3876)

Programs

• Synaptic modulation of neural circuits and behavior

Projects

• TOP DOWN REGULATION OF MOTIVATED BEHAVIORS BY LATERAL SEPTAL INTEGRATION OF CORTICO-HIPPOCAMPAL INPUTS
• ERC – TOP DOWN REGULATION OF MOTIVATED BEHAVIORS BY LATERAL SEPTAL INTEGRATION OF CORTICO-HIPPOCAMPAL INPUTS (MotivatedBehaviors)

Articles

• Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice. De León Reyes NS, Sierra Díaz P, Nogueira R, Ruiz-Pino A, Nomura Y, De Solis CA, Schulkin J, Asok A & Leroy F. Cell. 2023 186 (19), pp. 4152 - 4171.e31 https://doi.org/10.1016/j.cell.2023.08.010
• Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder. Staffa, A., Chatterjee, M., Diaz-Tahoces, A., Leroy, F., Perez-Otaño, I. J. Vis. Exp. 2023 e65958 https://doi.org/10.3791/65958
• A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory. Lopez-Rojas J, de Solis CA, Leroy F, Kandel ER, Siegelbaum SA Neuron 2022 110 (9), pp. 1559-1572.e4 https://doi.org/10.1016/j.neuron.2022.01.028
• Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memory. Leroy F, de Solis CA, Boyle LM, Bock T, Lofaro OM, Buss EW, Asok A, Kandel ER, Siegelbaum SA Mol Psychiatry. 2022 27 (6): 2879-2900 https://doi.org/10.1038/s41380-021-01124-y
• Top-down regulation of motivated behaviors via lateral septum sub-circuits. Besnard, A#., Leroy, F.# Mol Psychiatry . 2022 27 (8): 3119-3128 https://doi.org/10.1038/s41380-022-01599-3
• Hippocampal CA2 sharp-wave ripples reactivate and promote social memory Azahara Oliva, Antonio Fernández-Ruiz, Felix Leroy & Steven A. Siegelbaum Nature 2020 587: 264 http://doi.org/10.1038/s41586-020-2758-y
• Molecular Mechanisms of the Memory Trace Asok A,Leroy F, Rayman J and Kandel ER Trends in Neuroscience 2019 42(1): 14 http://doi.org/10.1016/j.tins.2018.10.005
• A circuit from hippocampal CA2 to lateral septum disinhibits social aggression Leroy F,Park J, Asok A, Brann DH, Meira T, Boyle LM, Buss EW, Kandel ER and Siegelbaum SA Nature 2018 564(7735): 213 https://doi.org/10.1038/s41586-018-0772-0

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