Personal
Felix Leroy

Group

• Cognition and social interactions
  https://in.umh-csic.es/group3876 Copied!

Programs

• Synaptic modulation of neural circuits and behavior

Projects

• Regulation of Social Preferences by the Lateral Septum
• Distintivo AGAIN en el IN 2025
• ERC – Infusion of CRHR1 agonists in the lateral septum to rescue social preference in a mouse model of schizophrenia
• Young Investigator Programme

Articles

• Interhemispheric CA1 projections to the subiculum support spatial cognition and are affected in a mouse model of the 22q11.2 deletion syndrome. De León Reyes, N.S., Bortolozzo-Gleich, M.H., Velez Gonzalez, H.N., Nomura, Y., García Frigola, C., Nieto, M., Gogos, J.A. & Leroy, F. Cell Reports. 2026 45: 117114 https://doi.org/10.1016/j.celrep.2026.117114
• Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3B+/- male mice. Bortolozzo-Gleich MH, Bouisset G, Leng L, Ruiz Pino A, Nomura Y, Han S, Li Y and Leroy F. Nature Communications. 2025 16, 6783 https://doi.org/10.1038/s41467-025-61994-6
• Self-experience of a negative event alters responses to others in similar states through prefrontal cortex CRF mechanisms. Federica Maltese, Giada Pacinelli, Anna Monai, Fabrizio Bernardi, Ana Marta Capaz, Marco Niello, Roman Walle, Noelia de Leon, Francesca Managò, Felix Leroy & Francesco Papaleo. Nature Neuroscience. 2025 28: 122–136 https://doi.org/10.1038/s41593-024-01816-y
• A magneto-mechanical genetics toolbox for in vivo neuromodulation. Leroy, F. Nat. Nanotechnol. 2024 19: pages1245–1246 https://doi.org/10.1038/s41565-024-01701-6
• Early cortical GABAergic interneurons determine the projection patterns of L4 excitatory neurons. Lorena Bragg-Gonzalo, Alfonso Aguilera, Candela González-Arias, Noelia S. De León Reyes, Alonso Sánchez-Cruz Paula Carballeira, Félix Leroy, Gertrudis Perea, and Marta Nieto Science Advances. 2024 10, Issue 19 https://doi.org/10.1126/sciadv.adj9911
• Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice. De León Reyes NS, Sierra Díaz P, Nogueira R, Ruiz-Pino A, Nomura Y, De Solis CA, Schulkin J, Asok A & Leroy F. Cell. 2023 186 (19), pp. 4152 - 4171.e31 https://doi.org/10.1016/j.cell.2023.08.010
• Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder. Staffa, A., Chatterjee, M., Diaz-Tahoces, A., Leroy, F., Perez-Otaño, I. J. Vis. Exp. 2023 e65958 https://doi.org/10.3791/65958
• A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory. Lopez-Rojas J, de Solis CA, Leroy F, Kandel ER, Siegelbaum SA Neuron 2022 110 (9), pp. 1559-1572.e4 https://doi.org/10.1016/j.neuron.2022.01.028
• Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memory. Leroy F, de Solis CA, Boyle LM, Bock T, Lofaro OM, Buss EW, Asok A, Kandel ER, Siegelbaum SA Mol Psychiatry. 2022 27 (6): 2879-2900 https://doi.org/10.1038/s41380-021-01124-y
• Top-down regulation of motivated behaviors via lateral septum sub-circuits. Besnard, A#., Leroy, F.# Mol Psychiatry . 2022 27 (8): 3119-3128 https://doi.org/10.1038/s41380-022-01599-3
• Hippocampal CA2 sharp-wave ripples reactivate and promote social memory Azahara Oliva, Antonio Fernández-Ruiz, Felix Leroy & Steven A. Siegelbaum Nature 2020 587: 264 http://doi.org/10.1038/s41586-020-2758-y
• Molecular Mechanisms of the Memory Trace Asok A,Leroy F, Rayman J and Kandel ER Trends in Neuroscience 2019 42(1): 14 http://doi.org/10.1016/j.tins.2018.10.005
• A circuit from hippocampal CA2 to lateral septum disinhibits social aggression Leroy F,Park J, Asok A, Brann DH, Meira T, Boyle LM, Buss EW, Kandel ER and Siegelbaum SA Nature 2018 564(7735): 213 https://doi.org/10.1038/s41586-018-0772-0

See more articles