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Lines of investigation
Research lines of our laboratory are focused on the identification of genes and proteins implicated in the occurrence and development of psychiatric (anxiety, depression, substance use, post-traumatic stress, etc.) and neurological (Parkinson´s disease, Alzheimer´s disease, etc.) disorders, which can be relevant for the discovery of new therapeutic targets to improve its pharmacological management.
For that purpose, we employ validated animal models of the psychiatric and neurological disorders that we want to study. These animal models must be able to reproduce, at least in part, certain behavioural traits and/or neurobiological features of the illnesses that they are simulating. Thus, the objective is to enhance the translational capacity of animal modelization that allows for applying the results to the patient.
The improvement of our knowledge about the alterations implicated in the aetiology and the development of different psychiatric and neurological disorders is one of our main goals, closely related with the discovery of more effective and safer pharmacological approaches. In the last years, we are focused on the role of the endocannabinoid system in the regulation of different brain functions and its potential pharmacotherapeutic exploitation. To this aim, we are very interested in the behavioural and neurochemical effects of genetic or pharmacological manipulation of the endocannabinoid system, employing transgenic animal models or cannabinoid compounds, respectively.
In our studies, we design and perform experiments to evaluate behavioral features related with emotional (anxiety, depression, stress, etc.) and cognitive (prepulse inhibition, memory impairment, etc.) alterations, and with the reinforcing and motivational effects of drugs of abuse (alcohol, cocaine, etc.). Furthermore, to evaluate the neurochemical changes that could be related with behaviour, we analyse gene expression of key targets by real time PCR or in situ hybridization experiments, as well as protein expression by immunohistochemistry or Western Blot techniques.
Laboratory members have a long-lasting and continuous relationship with several groups of psychiatrists and neurologists. This fact has significantly contributed to establish a reciprocal bridge of information between preclinical and clinical research, which has been reflected in several joint publications. Our objective is to maintain and to strengthen this type of collaborative strategies aimed to encourage translational research and finally improve the quality of life of psychiatric and neurological patients.
Representative Publications
- A comprehensive review of the multifaceted role of cannabinoid receptor type 2 in neurodegenerative and neuropsychiatric disorders. María S. García-Gutiérrez , Abraham B. Torregrosa, Francisco Navarrete, Daniela Navarro , Jorge Manzanares Pharmacological Research. 2025 213: 107657 https://doi.org/10.1016/j.phrs.2025.107657
- Changes in neurobiological markers of reactivity to alcohol-related stimuli in alcohol-dependent patients after two years of treatment. Gabriel Rubio, Marta Marín, Cristina Martín-Arriscado Arroba, Enrique Rubio-Escobar, Francisco Arias, Abraham B. Torregrosa, Jorge Manzanares. Front. Psychiatry. 2025 Volume 16 - Sec. Addictive Disorders https://doi.org/10.3389/fpsyt.2025.1613169
- Editorial: Methylation in the human brain. Sheila T. Nagamatsu, Francisco Navarrete, Maria S. Garcia-Gutierrez. Front. Genet. 2025 Sec. Behavioral and Psychiatric Genetics; Volume 16 https://doi.org/10.3389/fgene.2025.1589816
- ESTraS, an easy and simple tracking system for assessing rodent behavior. A. Morcuende, T. Femenía, J. Manzanares & A. Gasparyan. Behav Res. 2025 57; article number 90 https://doi.org/10.3758/s13428-024-02537-7
- Whole transcriptome analysis of peripheral blood mononuclear cells from de novo and drug-naïve Parkinson’s disease patients. Navarrete F, Guillot-Fernández M, Martínez-Hostyn L, Navarro D, Molina J A, López-Atalaya J P and Manzanares J. Neurotherapeutics. 2025 e00762 https://doi.org/10.1016/j.neurot.2025.e00762
- Additive antinociceptive action of intrathecal anandamide reuptake inhibitor and morphine in the management of post-incisional pain in rats. Antonio J. Carrascosa, María S. García-Gutiérrez, Raquel Saldaña, Jorge Manzanares. Biomedicine & Pharmacotherapy. 2024 177: 117054 https://doi.org/10.1016/j.biopha.2024.117054
- Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTPβ/ζ. Milagros Galán-Llario , Esther Gramage, Alba García-Guerra, Abraham B. Torregrosa , Ani Gasparyan , Daniela Navarro , Francisco Navarrete , María Salud García-Gutiérrez , Jorge Manzanares, Gonzalo Herradón Neuropharmacology. 2024 247: 109850 https://doi.org/10.1016/j.neuropharm.2024.109850
- Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality. Antonio J Carrascosa, Francisco Navarrete , Raquel Saldaña María S García-Gutiérrez, Belinda Montalbán , Daniela Navarro, Fernando M Gómez-Guijarro, Ani Gasparyan, Elena Murcia-Sánchez , Abraham B Torregrosa, Paloma Pérez-Doblado, Luisa Gutiérrez, Jorge Manzanares. Int J Mol Sci. 2024 25(11): 6268 https://doi.org/10.3390/ijms25116268
- Fetal Cannabinoid Syndrome: Behavioral and Brain Alterations of the Offspring Exposed to Dronabinol during Gestation and Lactation. Daniela Navarro, Ani Gasparyan, Francisco Navarrete and Jorge Manzanares. Int. J. Mol. Sci. 2024 25(13), 7453 https://doi.org/10.3390/ijms25137453
- Cannabidiol repairs brain damage and behavioral alterations in mice with fetal alcohol spectrum Ani Gasparyan, Daniela Navarro, Francisco Navarrete, Amaya Austrich-Olivares, Ernest R.Scoma, Vedangi D.Hambardikar, Gabriela B. Acosta, María E.Solesio, Jorge Manzanares Pharmacological Research 2023 Volume 188, February 2023, 106655 https://doi.org/10.1016/j.phrs.2023.106655
Group leader
Staff Scientist
Staff Scientist
Staff Scientist
Postdoctoral Researcher
Postdoctoral Researcher
Predoctoral Researcher
Predoctoral Researcher
Predoctoral Researcher
- A comprehensive review of the multifaceted role of cannabinoid receptor type 2 in neurodegenerative and neuropsychiatric disorders. María S. García-Gutiérrez , Abraham B. Torregrosa, Francisco Navarrete, Daniela Navarro , Jorge Manzanares Pharmacological Research. 2025 213: 107657 https://doi.org/10.1016/j.phrs.2025.107657
- Changes in neurobiological markers of reactivity to alcohol-related stimuli in alcohol-dependent patients after two years of treatment. Gabriel Rubio, Marta Marín, Cristina Martín-Arriscado Arroba, Enrique Rubio-Escobar, Francisco Arias, Abraham B. Torregrosa, Jorge Manzanares. Front. Psychiatry. 2025 Volume 16 - Sec. Addictive Disorders https://doi.org/10.3389/fpsyt.2025.1613169
- Editorial: Methylation in the human brain. Sheila T. Nagamatsu, Francisco Navarrete, Maria S. Garcia-Gutierrez. Front. Genet. 2025 Sec. Behavioral and Psychiatric Genetics; Volume 16 https://doi.org/10.3389/fgene.2025.1589816
- ESTraS, an easy and simple tracking system for assessing rodent behavior. A. Morcuende, T. Femenía, J. Manzanares & A. Gasparyan. Behav Res. 2025 57; article number 90 https://doi.org/10.3758/s13428-024-02537-7
- Whole transcriptome analysis of peripheral blood mononuclear cells from de novo and drug-naïve Parkinson’s disease patients. Navarrete F, Guillot-Fernández M, Martínez-Hostyn L, Navarro D, Molina J A, López-Atalaya J P and Manzanares J. Neurotherapeutics. 2025 e00762 https://doi.org/10.1016/j.neurot.2025.e00762
- Differences in Substance Use Disorders and Other Mental Disorders in Mental Health and Addiction Settings: Sociodemographic, Clinical, Drug Treatment, and Gender Differences. Fernández-Miranda, J.J., Pascual-Pastor, F., Díaz-Fernández, S., Navarro, D., Manzanares, J. Int J Mental Health and Addiction. 2024 22: pages 2338–2356 https://doi.org/10.1007/s11469-022-00989-6
- Additive antinociceptive action of intrathecal anandamide reuptake inhibitor and morphine in the management of post-incisional pain in rats. Antonio J. Carrascosa, María S. García-Gutiérrez, Raquel Saldaña, Jorge Manzanares. Biomedicine & Pharmacotherapy. 2024 177: 117054 https://doi.org/10.1016/j.biopha.2024.117054
- Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTPβ/ζ. Milagros Galán-Llario , Esther Gramage, Alba García-Guerra, Abraham B. Torregrosa , Ani Gasparyan , Daniela Navarro , Francisco Navarrete , María Salud García-Gutiérrez , Jorge Manzanares, Gonzalo Herradón Neuropharmacology. 2024 247: 109850 https://doi.org/10.1016/j.neuropharm.2024.109850
- Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality. Antonio J Carrascosa, Francisco Navarrete , Raquel Saldaña María S García-Gutiérrez, Belinda Montalbán , Daniela Navarro, Fernando M Gómez-Guijarro, Ani Gasparyan, Elena Murcia-Sánchez , Abraham B Torregrosa, Paloma Pérez-Doblado, Luisa Gutiérrez, Jorge Manzanares. Int J Mol Sci. 2024 25(11): 6268 https://doi.org/10.3390/ijms25116268
- Fetal Cannabinoid Syndrome: Behavioral and Brain Alterations of the Offspring Exposed to Dronabinol during Gestation and Lactation. Daniela Navarro, Ani Gasparyan, Francisco Navarrete and Jorge Manzanares. Int. J. Mol. Sci. 2024 25(13), 7453 https://doi.org/10.3390/ijms25137453
- Isobolographic Analysis of the Cytoprotective Effect of Dapsone and Cannabidiol Alone or Combination upon Oxygen–Glucose Deprivation/Reoxygenation Model in SH-SY5Y Cells. Marcela Islas-Cortez ,Camilo Ríos ,Jorge Manzanares ,Araceli Díaz-Ruiz, Ricardo Pérez-Pastén-Borja Antioxidants. 2024 13(6): 705 https://doi.org/10.3390/antiox13060705
- Understanding the Biological Relationship between Migraine and Depression. Adrián Viudez-Martínez, Abraham B. Torregrosa ,Francisco Navarrete and María Salud García-Gutiérrez. Biomolecules. 2024 14(2): 163 https://doi.org/10.3390/biom14020163
- Cannabidiol repairs brain damage and behavioral alterations in mice with fetal alcohol spectrum Ani Gasparyan, Daniela Navarro, Francisco Navarrete, Amaya Austrich-Olivares, Ernest R.Scoma, Vedangi D.Hambardikar, Gabriela B. Acosta, María E.Solesio, Jorge Manzanares Pharmacological Research 2023 Volume 188, February 2023, 106655 https://doi.org/10.1016/j.phrs.2023.106655
- Emotional Processing and Maltreatment During Childhood as Factors of Vulnerability to Alcohol Abuse in Young Adults. Gabriel Rubio, Ani Gasparyan, Almudena Duque, María Salud García-Gutiérrez, Francisco Navarrete, Daniela Navarro & Jorge Manzanares Int J Ment Health Addiction. 2023 June 2023 https://doi.org/10.1007/s11469-023-01097-9
- Role of CB2 cannabinoid receptor in the development of food addiction in male mice. A. García-Blanco, Á. Ramírez-López , F. Navarrete, M.S. García-Gutiérrez, J. Manzanares, E. Martín-García, R. Maldonado Neurobiology of Disease. 2023 179, April 2023, 106034 https://doi.org/10.1016/j.nbd.2023.106034
- Cannabidiol regulates behavioral and brain alterations induced by spontaneous alcohol withdrawal. Ani Gasparyan , Francisco Navarrete, Daniela Navarro, Jorge Manzanares Neuropharmacology. 2023 233: 109549 https://doi.org/10.1016/j.neuropharm.2023.109549
- Alterations of BDNF, mGluR5, Homer1a, p11 and excitatory/inhibitory balance in corticolimbic brain regions of suicide decedents. María S. García-Gutiérrez, Daniela Navarro, Abraham B. Torregrosa, Adrián Viudez-Martínez Salvador Giner, Jorge Manzanares Journal of Affective Disorders. 2023 339 (15): 366-376 https://doi.org/10.1016/j.jad.2023.07.003
- Molecular Changes Associated with Suicide. Daniela Navarro, Marta Marín-Mayor ,Ani Gasparyan ,María Salud García-Gutiérrez ,Gabriel Rubio and Jorge Manzanares Int. J. Mol. Sci. 2023 24 (23), 16726 - Review https://doi.org/10.3390/ijms242316726
- Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach. Daniela Navarro, Ani Gasparyan ,Silvia Martí Martínez ,Carmen Díaz Marín ,Francisco Navarrete ,María Salud García Gutiérrez and Jorge Manzanares Int. J. Mol. Sci. 2023 24 (8), 7653 https://doi.org/10.3390/ijms24087653
- Cognitive Alterations in Addictive Disorders: A Translational Approach. Ani Gasparyan ,Daniel Maldonado Sanchez ,Francisco Navarrete,Ana Sion ,Daniela Navarro,María Salud García-Gutiérrez,Gabriel Rubio Valladolid ,Rosa Jurado Barba andJorge Manzanares Biomedicines. 2023 11 (7): 1796 https://doi.org/10.3390/biomedicines11071796
- Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model. María Salud García-Gutiérrez, Daniela Navarro, Amaya Austrich-Olivares ,Jorge Manzanares Front. Pharmacol. 2023 Sec. Experimental Pharmacology and Drug Discovery; Volume 14 https://doi.org/10.3389/fphar.2023.1171646
- Editorial: Cannabidiol treatment in neurotherapeutic interventions, volume II. Gustavo Gonzalez-Cuevas , Francisco Navarrete, Maria S. Garcia-Gutierrez, Giordano de Guglielmo, Jorge Manzanares Front. Pharmacol. 2023 Sec. Neuropharmacology Volume 14 - Editorial https://doi.org/10.3389/fphar.2023.1163991
- Biomarkers of the Endocannabinoid System in Substance Use Disorders. Navarrete F, García-Gutiérrez MS, Gasparyan A, Navarro D, López-Picón F, Morcuende Á, Femenía T, Manzanares J Biomolecules. 2022 12(3): art 396 https://doi.org/10.3390/biom12030396
- CBD-mediated regulation of heroin withdrawal-induced behavioural and molecular changes in mice. Navarrete F, Gasparyan A, Manzanares J Addict Biol. 2022 27(2) :art. e13150 https://doi.org/10.1111/adb.13150
- Pharmacological strategies for post-traumatic stress disorder (PTSD): From animal to clinical studies Gasparyan, A., Navarro, D., Navarrete, F., Manzanares, J. Neuropharmacology 2022 218: art 109211 - Review https://doi.org/10.1016/j.neuropharm.2022.109211
- Cannabidiol attenuates hypersensitivity and oxidative stress after traumatic spinal cord injury in rats. Baron-Flores, V., Diaz-Ruiz, A., Manzanares, J., Rios, C., Burelo, M., Jardon-Guadarrama, G., Martínez-Cárdenas, M.D.L.Á., Mata-Bermudez, A. Neurosci Lett . 2022 788: art. 136855 https://doi.org/10.1016/j.neulet.2022.136855
- Role of Cannabinoid CB2 Receptor in Alcohol Use Disorders: From Animal to Human Studies. García-Gutiérrez, M.S., Navarrete, F., Gasparyan, A., Navarro, D., Morcuende, Á., Femenía, T., Manzanares, J. Int J Mol Sci . 2022 23 (11): art. 5908 Review https://10.3390/ijms23115908
- Molecular Alterations of the Endocannabinoid System in Psychiatric Disorders. Navarro, D., Gasparyan, A., Navarrete, F., Torregrosa, A.B., Rubio, G., Marín-Mayor, M., Acosta, G.B., Garcia-Gutiérrez, M.S., Manzanares, J. Int J Mol Sci . 2022 23 (9) : art. 4764 Review https://doi.org/10.3390/ijms23094764
- Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders. Morcuende, A., García-Gutiérrez, M.S., Tambaro, S., Nieto, E., Manzanares, J., Femenia, T. Front Psychiatry. 2022 13: 866052 - Review https://doi.org/10.3389/fpsyt.2022.866052
- Cannabinoid CB1 Receptor Involvement in the Actions of CBD on Anxiety and Coping Behaviors in Mice. Austrich-Olivares, A., García-Gutiérrez, M.S., Illescas, L., Gasparyan, A., Manzanares, J. Pharmaceuticals (Basel) . 2022 15(4): 473 https://doi.org/10.3390/ph15040473
- Cannabidiol and Sertraline Regulate Behavioral and Brain Gene Expression Alterations in an Animal Model of PTSD Gasparyan A, Navarrete F, Manzanares J Front Pharmacol 2021 12:694510 https://doi.org/10.3389/fphar.2021.694510
- Cannabidiol Modulates Behavioural and Gene Expression Alterations Induced by Spontaneous Cocaine Withdrawal Gasparyan A, Navarrete F, Rodríguez-Arias M, Miñarro J, Manzanares J Neurotherapeutics 2021 18(1):615 https://doi.org/10.1007/s13311-020-00976-6
- Cannabidiol prevents priming- and stress-induced reinstatement of the conditioned place preference induced by cocaine in mice. Calpe-López C, Gasparyan A, Navarrete F, Manzanares J, Miñarro J, Aguilar MA J Psychopharmacol 2021 35(7):864 https://doi.org/10.1177/0269881120965952
- CB2 Receptor Involvement in the Treatment of Substance Use Disorders Navarrete F, García-Gutiérrez MS, Gasparyan A, Navarro D, Manzanares J Biomolecules 2021 11(11):1556 https://doi.org/10.3390/biom11111556
- Differences in Gene Expression of Endogenous Opioid Peptide Precursor, Cannabinoid 1 and 2 Receptors and Interleukin Beta in Peripheral Blood Mononuclear Cells of Patients With Refractory Failed Back Surgery Syndrome Treated With Spinal Cord Stimulation: Markers of Therapeutic Outcomes? De Andrés J, Navarrete-Rueda F, Fabregat G, García-Gutiérrez MS, Monsalve-Dolz V, Harutyunyan A, Mínguez-Martí A, Rodriguez-Lopez R, Manzanares J Neuromodulation 2021 24(1):49 https://doi.org/10.1111/ner.13111
- Editorial: Cannabidiol Treatment in Neurotherapeutic Interventions Gonzalez-Cuevas G, Garcia-Gutierrez MS, Navarrete F, de Guglielmo G, Manzanares J Front Pharmacol 2021 12:752292 https://doi.org/10.3389/fphar.2021.752292
- Editorial: The Search for Biomarkers in Psychiatry Garcia-Gutierrez MS, Manzanares J, Navarrete F Front Psychiatry 2021 12:720411 https://doi.org/10.3389/fpsyt.2021.720411
- Inflammatory Biomarkers in Addictive Disorders Morcuende A, Navarrete F, Nieto E, Manzanares J, Femenía T Biomolecules 2021 11(12):1824 https://doi.org/10.3390/biom11121824
- Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice González-Portilla M, Montagud-Romero S, Navarrete F, Gasparyan A, Manzanares J, Miñarro J, Rodríguez-Arias M Int J Mol Sci 2021 22(10):5279 https://doi.org/10.3390/ijms22105279
- Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders Navarrete F, García-Gutiérrez MS, Gasparyan A, Austrich-Olivares A, Manzanares J Front Pharmacol 2021 12:626010 https://doi.org/10.3389/fphar.2021.626010
- The administration of sertraline plus naltrexone reduces ethanol consumption and motivation in a long-lasting animal model of post-traumatic stress disorder Gasparyan A,Navarrete F, Manzanares J Neuropharmacol 2021 189:108552 https://doi.org/10.1016/j.neuropharm.2021.108552
- Association of cannabinoid receptor genes (CNR1 and CNR2) polymorphisms and panic disorder Peiró AM, García-Gutiérrez MS, Planelles B, Femenía T, Mingote C, Jiménez-Treviño L, Martínez-Barrondo S, García-Portilla MP, Saiz PA, Bobes J, Manzanares J Anxiety Stress Coping 2020 33(3):256 https://doi.org/10.1080/10615806.2020.1732358
- Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality García-Gutiérrez MS, Navarrete F, Sala F, Gasparyan A, Austrich-Olivares A, Manzanares J Front Psychiatry 2020 11:432 https://doi.org/10.3389/fpsyt.2020.00432
- Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders García-Gutiérrez MS, Navarrete F, Gasparyan A, Austrich-Olivares A, Sala F, Manzanares J Biomolecules 2020 10(11):1575 https://doi.org/10.3390/biom10111575
- Cannabis Use in Pregnant and Breastfeeding Women: Behavioral and Neurobiological Consequences Navarrete F, García-Gutiérrez MS, Gasparyan A, Austrich-Olivares A, Femenía T, Manzanares J Front Psychiatry 2020 11:586447 https://doi.org/10.3389/fpsyt.2020.586447
- Endocannabinoid System Components as Potential Biomarkers in Psychiatry Navarrete F, García-Gutiérrez MS, Jurado-Barba R, Rubio G, Gasparyan A, Austrich-Olivares A, Manzanares J Front Psychiatry 2020 11:315 https://doi.org/10.3389/fpsyt.2020.00315
- Gender differences in the effects of cannabidiol on ethanol binge drinking in mice Viudez-Martínez A, García-Gutiérrez MS, Manzanares J Addict Biol 2020 25(3):e12765 https://doi.org/10.1111/adb.12765
- Neuropsychophysiological Measures of Alcohol Dependence: Can We Use EEG in the Clinical Assessment? Jurado-Barba R, Sion A, Martínez-Maldonado A, Domínguez-Centeno I, Prieto-Montalvo J, Navarrete F, García-Gutierrez MS, Manzanares J, Rubio G Front Psychiatry 2020 11:676 https://doi.org/10.3389/fpsyt.2020.00676
- Cannabidiol does not display drug abuse potential in mice behavior Viudez-Martinez A, García-Gutierrez MS, Medrano-Relinque J, Navarron CM, Navarrete F, Manzanares J Acta Pharmacologica Sinica 2019 40(3):358 https://doi.org/10.1038/s41401-018-0032-8
- Measurement of CSF alpha-synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer’s disease García-Ayllón MS, Monge-Argilés JA, Monge-García V, Navarrete F, Cortés-Gómez MA, Sánchez-Payá J, Manzanares J, Gasparini-Berenguer R, Leiva-Santana C, Sáez-Valero J Journal of Neurochemistry 2019 150(2):218 https://doi.org/10.1111/jnc.14719
- Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims Garcia-Gutierrez MS, Navarrete F, Navarro G, Reyes-Resina I, Franco R, Lanciego JL, Giner S, Manzanares J Neurotherapeutics 2018 15(3):796 https://doi.org/10.1007/s13311-018-0610-y
- Cannabidiol reduces ethanol consumption, motivation and relapse in mice Viudez-Martinez A, Garcia-Gutierrez MS, Navarron CM, Morales-Calero MI, Navarrete F, Torres-Suarez A, Manzanares J Addict Biol 2018 23(1):154 https://doi.org/10.1111/adb.12495
- Cannabidiol regulates behavioural alterations and gene expression changes induced by spontaneous cannabinoid withdrawal Navarrete F, Aracil-Fernandez A, Manzanares J Br J Pharmacol 2018 175(13):2676 https://doi.org/10.1111/bph.14226
- Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress Viudez-Martinez A, Garcia-Gutierrez MS, Manzanares J J Psychopharmacol 2018 32(12):1379 https://doi.org/10.1177/0269881118805495
- Cannabinoid CB1 and CB2Receptors, and Monoacylglycerol Lipase Gene Expression Alterations in the Basal Ganglia of Patients with Parkinson’s Disease Navarrete F, Garcia-Gutierrez MS, Aracil-Fernandez A, Lanciego JL, Manzanares J Neurotherapeutics 2018 15(2):459 https://doi.org/10.1007/s13311-018-0603-x
- Deletion of Dlk1 increases the vulnerability to developing anxiety-like behaviors and ethanol consumption in mice García-Gutierrez MS, Navarrete F, Laborda J, Manzanares J Biochem Pharmacol 2018 158:37 https://doi.org/10.1016/j.bcp.2018.09.029
- Effects of cannabidiol plus naltrexone on motivation and ethanol consumption Viudez-Martínez A, García-Gutiérrez MS, Fraguas-Sánchez AI Torres-Suárez AI, Manzanares J Br J Pharmacol 2018 175(16):3369 https://doi.org/10.1111/bph.14380
- Pharmacological regulation of cannabinoid CB2 receptor modulates the reinforcing and motivational actions of ethanol Navarrete F, Garcia-Gutierrez MS, Manzanares J Biochem Pharmacol 2018 157:227 https://doi.org/10.1016/j.bcp.2018.07.041
- Role of the endocannabinoid system in drug addiction Manzanares J, Cabañero D, Puente N, García-Gutiérrez MS, Grandes P, Maldonado R Biochem Pharmacol 2018 157:108 https://doi.org/10.1016/j.bcp.2018.09.013
- Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet Blanco-Gandia MC, Aracil-Fernandez A, Montagud-Romero S, Aguilar MA, Manzanares J, Miñarro J, Rodriguez-Arias M Psychopharmacology 2017 234(15):2337 https://doi.org/10.1007/s00213-017-4630-9
- Different Molecular/Behavioral Endophenotypes in C57BL/6J Mice Predict the Impact of OX1 Receptor Blockade on Binge-Like Ethanol Intake Alcaraz-Iborra M, Navarrete F, Rodríguez-Ortega E, de la Fuente L, Manzanares J, Cubero I Front Behav Neurosci 2017 11:186 https://doi.org/10.3389/fnbeh.2017.00186
- Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model Rubio-Araiz A, Porcu F, Perez-Hernandez M, Garcia-Gutierrez MS, Aracil-Fernandez MA, Gutierrez-Lopez MD, Guerri C, Manzanares J, O'Shea E, Colado MI Addict Biol 2017 22(4):1103 https://doi.org/10.1111/adb.12376
- Effects of bingeing on fat during adolescence on the reinforcing effects of cocaine in adult male mice Blanco-Gandia MC, Cantacorps L, Aracil-Fernandez A, Montagud-Romero S, Aguilar MA, Manzanares J, Valverde O, Minarro J, Rodriguez-Arias M Neuropharmacology 2017 113:31 https://doi.org/10.1016/j.neuropharm.2016.09.020
- Human-specific genomic signatures of neocortical expansion Florio M, Borrell V, Huttner WB Curr Opin Neurobiol 2017 42:33 https://doi.org/10.1016/j.conb.2016.11.004
- Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice Negrete R, Garcia Gutierrez MS, Manzanares J, Maldonado R Neuropharmacology 2017 116():315 https://doi.org/10.1016/j.neuropharm.2016.08.026
- NEW DEVELOPMENTS IN NEUROSCIENCE FOR 2017 Lerma J Neuroscience 2017 343:298 https://doi.org/10.1016/j.neuroscience.2016.12.022
- Psychological symptomatology and impaired prepulse inhibition of the startle reflex are associated with cannabis-induced psychosis Morales-Muñoz I, Martinez-Gras I, Ponce G, de la Cruz J, Lora D, Rodriguez-Jimenez R, Jurado-Barba R, Navarrete F, Garcia-Gutierrez MS, Manzanares J, Rubio G J Psychopharmacol 2017 31(8):1035 https://doi.org/10.1177/0269881117711920
- The Modulation of the Startle Reflex as Predictor of Alcohol Use Disorders in a Sample of Heavy Drinkers: A 4-Year Follow-Up Study Jurado-Barba R, Duque A, Lopez-Trabada JR, Martinez-Gras I, Garcia-Gutierrez MS, Navarrete F, Lopez-Muñoz F, Jimenez-Arriero Ma, avila C, Manzanares J, Rubio G Alcohol Clin Exp Res 2017 41(6):1212 https://doi.org/10.1111/acer.13399
- Association between maltreatment and polydrug use among adolescents Alvarez-Alonso MJ, Jurado-Barba R, Martinez-Martin N, Espin-Jaime JC, Bolaños-Porrero C, Ordoñez-Franco A, Rodriguez-Lopez JA, Lora-Pablos D, de la Cruz-Bertolo J, Jimenez-Arriero MA, Manzanares J, Rubio G Child Abuse Negl 2016 51:379 https://doi.org/10.1016/j.chiabu.2015.07.014
- Increased Expression of Readthrough Acetylcholinesterase Variants in the Brains of Alzheimer’s Disease Patients Campanari ML, Navarrete F, Ginsberg SD, Manzanares J, Saez-Valero J, Garcia-Ayllon MS J Alzheimers Dis 2016 53(3):831 https://doi.org/10.3233/JAD-160220
- Increased vulnerability to ethanol consumption in adolescent maternal separated mice Garcia-Gutierrez MS, Navarrete F, Aracil A, Bartoll A, Martinez-Gras I, Lanciego JL, Rubio G, Manzanares J Addict Biol 2016 21(4):847 https://doi.org/10.1111/adb.12266
- Social defeat in adolescent mice increases vulnerability to alcohol consumption Rodriguez-Arias M, Navarrete F, Blanco-Gandia MC, Arenas MC, Bartoll-Andres A, Aguilar MA, Rubio G, Miñarro J, Manzanares J Addict Biol 2016 21(1):87 https://doi.org/10.1111/adb.12184
- Topiramate increases the rewarding properties of cocaine in young-adult mice limiting its clinical usefulness Arenas MC, Mateos-Garcia A, Manzanedo C, Rodriguez-Arias M, Aguilar MA, Navarrete F, Gutierrez MS, Manzanares J, Miñarro J Psychopharmacology 2016 233(23-24):3849 https://doi.org/10.1007/s00213-016-4409-4
- Cannabidiol as a Potential Treatment for Anxiety Disorders Blessing EM, Steenkamp MM, Manzanares J, Marmar CR Neurotherapeutics 2015 12(4):825 https://doi.org/10.1007/s13311-015-0387-1
- Differential Pharmacological Regulation of Sensorimotor Gating Deficit in CB1 Knockout Mice and Associated Neurochemical and Histological Alterations Ortega-Alvaro A, Navarrete F, Aracil-Fernandez A, Navarro D, Berbel P, Manzanares J Neuropsychopharmacology 2015 40(11):2639 https://doi.org/10.1038/npp.2015.113
- Evidence against a critical role of CBI receptors in adaptation of the hypothalamic-pituitary-adrenal axis and other consequences of daily repeated stress Rabasa C, Pastor-Ciurana J, Delgado-Morales R, Gomez-Roman A, Carrasco J, Gagliano H, Garcia-Gutierrez MS, Manzanares J, Armario A Eur Neuropsychopharmacol 2015 25(8):1248 https://doi.org/10.1016/j.euroneuro.2015.04.026
- Gestational and early postnatal hypothyroidism alters VGIuT1 and VGAT bouton distribution in the neocortex and hippocampus, and behavior in rats Navarro D, Alvarado M, Navarrete F, Giner M, Obregon MJ, Manzanares J, Berbel P Front Neuroanat 2015 9:9 https://doi.org/10.3389/fnana.2015.00009
- Reduced Contextual Discrimination following Alcohol Consumption or MDMA Administration in Mice Johansson EM, Garcia-Gutierrez MS, Moscoso-Castro M, Manzanares J, Valverde O PLoS One 2015 10(11):e0142978 https://doi.org/10.1371/journal.pone.0142978
- Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol Ortega-Alvaro A, Ternianov A, Aracil-Fernandez A, Navarrete F, Garcia-Gutierrez MS, Manzanares J Addict Biol 2015 20(1):43 https://doi.org/10.1111/adb.12076
- Role of CB2 receptors in social and aggressive behavior in male mice Rodriguez-Arias M, Navarrete F, Blanco-Gandia MC, Arenas MC, Aguilar MA, Bartoll-Andres A, Valverde O, Miñarro J, Manzanares J Psychopharmacology 2015 232(16):3019 https://doi.org/10.1007/s00213-015-3939-5
- Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain La Porta C, Bura SA, Llorente-Onaindia J, Pastor A, Navarrete F, Garcia-Gutierrez MS, De la Torre R, Manzanares J, Monfort J, Maldonado R Pain 2015 156(10):2001 https://doi.org/10.1097/j.pain.0000000000000260
- Abnormal Expression Pattern of Notch Receptors, Ligands, and Downstream Effectors in the Dorsolateral Prefrontal Cortex and Amygdala of Suicidal Victims Monsalve EM, Garcia-Gutierrez MS, Navarrete F, Giner S, Laborda J, Manzanares J Mol Neurobiol 2014 49(2):957 https://doi.org/10.1007/s12035-013-8570-z
- Effects of naltrexone plus topiramate on ethanol self-administration and tyrosine hydroxylase gene expression changes Navarrete F, Rubio G, Manzanares J Addict Biol 2014 19(5):862 https://doi.org/10.1111/adb.12058
- Regulatory role of the cannabinoid CB2 receptor in stress- induced neuroinflammation in mice Zoppi S, Madrigal JL, Caso JR, Garcia-Gutierrez MS, Manzanares J, Leza JC, Garcia-Bueno B Br J Pharmacol 2014 171(11):2814 https://doi.org/10.1111/bph.12607
- CB1 cannabinoid receptor-mediated aggressive behavior Rodriguez-Arias M, Navarrete F, Daza-Losada M, Navarro D, Aguila MA, Berbel P, Miñarro J, Manzanares J Neuropharmacology 2013 75:172 https://doi.org/10.1016/j.neuropharm.2013.07.013
- Gene and protein alterations of FKBP5 and glucocorticoid receptor in the amygdala of suicide victims Perez-Ortiz JM, Garcia-Gutierrez MS, Navarrete F, Giner S, Manzanares J Psychoneuroendocrinology 2013 38(8):1251 https://doi.org/10.1016/j.psyneuen.2012.11.008
- Pregabalin and topiramate regulate behavioural and brain gene transcription changes induced by spontaneous cannabinoid withdrawal in mice Aracil-Fernandez A, Almela P, Manzanares J Addict Biol 2013 18(2):252 https://doi.org/10.1111/j.1369-1600.2011.00406.x
- Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate La Porta C, Bura SA, Aracil-Fernandez A, Manzanares J, Maldonado R Pain 2013 154(1):160 https://doi.org/10.1016/j.pain.2012.10.009
- Role of CB2 Cannabinoid Receptors in the Rewarding, Reinforcing, and Physical Effects of Nicotine Navarrete F, Rodriguez-Arias M, Martin-Garcia E, Navarro D, Garcia-Gutierrez MS, Aguilar MA, Aracil-Fernandez A, Berbel P, Miñarro J, Maldonado R, Manzanares J Neuropsychopharmacology 2013 38(12):2515 https://doi.org/10.1038/npp.2013.157
- Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors Garcia-Gutierrez MS, Ortega-Alvaro A, Busquets-Garcia A, Perez-Ortiz JM, Caltana L, Ricatti MJ, Brusco A, Maldonado R, Manzanares J Neuropharmacology 2013 73:388 https://doi.org/10.1016/j.neuropharm.2013.06.034
- Voluntary Alcohol Drinking Enhances Proopiomelanocortin Gene Expression in Nucleus Accumbens Shell and Hypothalamus of Sardinian Alcohol-Preferring Rats Zhou Y, Colombo G, Niikura K, Carai MAM, Femenia T, Garcia-Gutierrez MS, Manzanares J, Ho A, Gessa GL, Kreek MJ Alcohol Clin Exp Res 2013 37:E131 https://doi.org/10.1111/j.1530-0277.2012.01867.x
- Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice Gomez-Milanes I, Almela P, Garcia-Carmona JA, Garcia-Gutierrez MS, Aracil-Fernandez A, Manzanares J, Maquilon MVM, Laorden ML Neurochem Int 2012 61(3):433 https://doi.org/10.1016/j.neuint.2012.06.011
- Cannabinoid CB2 receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice Navarrete F, Perez-Ortiz JM, Manzanares J Br J Pharmacol 2012 165(1):260 https://doi.org/10.1111/j.1476-5381.2011.01542.x
- Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection Zarruk JG, Fernandez-Lopez D, Garcia-Yebenes I, Garcia-Gutierrez MS, Vivancos J, Nombela F, Torres M, Burquete MC, Manzanares J, Lizasoain I, Moro MA Stroke 2012 43(1):211 https://doi.org/10.1161/STROKEAHA.111.631044
- Changes in acetylcholinesterase expression are associated with altered presenilin-1 levels Silveyra MX, Garcia-Ayllon MS, Serra-Basante C, Mazzoni V, Garcia-Gutierrez MS, Manzanares J, Culvenor JG, Saez-Valero J Neurobiol Aging 2012 33(3):627.e27 https://doi.org/10.1016/j.neurobiolaging.2011.04.006
- Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors Garcia-Gutierrez MS, Garcia-Bueno B, Zoppi S, Leza JC, Manzanares J Br J Pharmacol 2012 165(4):951 https://doi.org/10.1111/j.1476-5381.2011.01625.x
- Decreased Cocaine Motor Sensitization and Self-Administration in Mice Overexpressing Cannabinoid CB(2) Receptors Aracil-Fernandez A, Trigo JM, Garcia-Gutierrez MS, Ortega-Alvaro A, Ternianov A, Navarro D, Robledo P, Berbel P, Maldonado R, Manzanares J Neuropsychopharmacology 2012 37(7):1749 https://doi.org/10.1038/npp.2012.22
- Endogenous cannabinoid system regulates intestinal barrier function in vivo through cannabinoid type 1 receptor activation Zoppi S, Madrigal JL, Perez-Nievas BG, Marin-Jimenez I, Caso JR, Alou L, Garcia-Bueno B, Colon A, Manzanares J, Gomez Lus ML, Menchen L, Leza JC Am J Physiol-Gastr L 2012 302(5):G565 https://doi.org/10.1152/ajpgi.00158.2011
- Increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission Femenia T, Manzanares J Addict Biol 2012 17(2):322 https://doi.org/10.1111/j.1369-1600.2011.00378.x
- Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats Vinod KY, Maccioni P, Garcia-Gutierrez MS, Femenia T, Xie S, Carai MA, Manzanares J, Cooper TB, Hungund BL, Colombo G Addict Biol 2012 17(1):62 https://doi.org/10.1111/j.1369-1600.2010.00299.x
- Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice Romero-Zerbo SY, Garcia-Gutierrez MS, Suarez J, Rivera P, Ruz-Maldonado I, Vida M, de Fonseca FR, Manzanares J, Bermudez-Silva FJ J Neuroendocrinol 2012 24(8):1106 https://doi.org/10.1111/j.1365-2826.2012.02325.x
- Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine Ternianov A, Perez-Ortiz JM, Solesio ME, Garcia-Gutierrez MS, Ortega-Alvaro A, Navarrete F, Leiva C, Galindo MF, Manzanares J Neurobiol Aging 2012 33(2):421.e1 https://doi.org/10.1016/j.neurobiolaging.2010.09.012
- Pregabalin and topiramate mediated regulation of cognitive and motor impulsivity in DBA/2 mice Navarrete F, Perez-Ortiz JM, Manzanares J Br J Pharmacol 2012 167(1):183 https://doi.org/10.1111/j.1476-5381.2012.01981.x
- Decreased GABA(A) and GABA(B) receptor functional activity in cannabinoid CB1 receptor knockout mice Uriguen L, Garcia-Gutierrez MS, Manzanares J J Psychopharmacol 2011 25(1):105 https://doi.org/10.1177/0269881109358204
- Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice Ortega-Alvaro A, Aracil-Fernandez A, Garcia-Gutierrez MS, Navarrete F, Manzanares J Neuropsychopharmacology 2011 36(7):1489 https://doi.org/10.1038/npp.2011.34
- Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects Marco EM, Garcia-Gutierrez MS, Bermudez-Silva FJ, Moreira FA, Guimaraes F, Manzanares J, Viveros MP Front Behav Neurosci 2011 5:63 https://doi.org/10.3389/fnbeh.2011.00063
- Increased vulnerability to 6-hydroxydopamine lesion and reduced development of dyskinesias in mice lacking CB1 cannabinoid receptors Perez-Rial S, Garcia-Gutierrez MS, Molina JA, Perez-Nievas BG, Ledent C, Leiva C, Leza JC, Manzanares J Neurobiol Aging 2011 32(4):631 https://doi.org/10.1016/j.neurobiolaging.2009.03.017
- Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice Garcia-Gutierrez MS, Manzanares J J Psychopharmacol 2011 25(1):111 https://doi.org/10.1177/0269881110379507
- Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABA(A) receptor subunits gene expression in the amygdala Femenia T, Perez-Rial S, Uriguen L, Manzanares J J Psychopharmacol 2011 25(1):87 https://doi.org/10.1177/0269881110367724
- Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation Zoppi S, Perez-Nievas BG, Madrigal JL, Manzanares J, Leza JC, Garcia-Bueno B Neuropsychopharmacology 2011 36(4):805 https://doi.org/10.1038/npp.2010.214
- CB1 Receptor Blockade Decreases Ethanol Intake and Associated Neurochemical Changes in Fawn-Hooded Rats Femenia T, Garcia-Gutierrez MS, Manzanares J Alcohol Clin Exp Res 2010 34(1):131 https://doi.org/10.1111/j.1530-0277.2009.01074.x.
- Depression-resistant endophenotype in mice overexpressing cannabinoid CB2 receptors Garcia-Gutierrez MS, Perez-Ortiz JM, Gutierrez-Adan A, Manzanares J Br J Pharmacol 2010 160(7):1773 https://doi.org/10.1111/j.1476-5381.2010.00819.x
- Regulation of Fas receptor/Fas-asssociated protein with death domain apoptotic complex and associated signalling systems by cannabinoid receptors in the mouse brain Alvaro-Bartolome M, Esteban S, Garcia-Gutierrez MS, Manzanares J, Valverde O, Garcia-Sevilla JA Br J Pharmacol 2010 160(3):643 https://doi.org/10.1111/j.1476-5381.2010.00710.x
- The cannabinoid CB1 receptor is involved in the anxiolytic, sedative and amnesic actions of benzodiazepines Garcia-Gutierrez MS, Manzanares J J Psychopharmacol 2010 24(5):757 https://doi.org/10.1177/0269881109106910
