Personal
Rafael Alcalá Vida
Tenure-Track Scientist
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Transcriptional and epigenetic mechanisms of neuronal plasticity
https://in.umh-csic.es/group3893
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→ Emerging line: Genome Architecture in neural systems
https://in.umh-csic.es/group100888
- Distintivo AGAIN StG 2024
- NeuroIDswitch: Desarrollo de un conmutador de la identidad neuronal mediante herramientas genéticas farmacológicamente controladas dirigidas a las proteínas KAT3
- Ayudas Ramón y Cajal 2024
- Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1. Baptiste Brulé, Rafael Alcalá-Vida, Noémie Penaud, Jil Scuto, Coline Mounier, Jonathan Seguin, Sina Vincent Khodaverdian, Brigitte Cosquer, Etienne Birmelé, Stéphanie Le Gras, Charles Decraene, Anne-Laurence Boutillier & Karine Merienne Nature Commun. 2025 16(1): 1550 https://doi.org/10.1038/s41467-025-56722-z
- Dysregulated expression of cholesterol biosynthetic genes in Alzheimer’s disease alters epigenomic signatures of hippocampal neurons. Paiva I, Seguin J, Grgurina I, Singh AK, Cosquer B, Plassard D, Tzeplaeff L, Le Gras S, Cotellessa L, Decraene C, Gambi J, Alcala-Vida R, Eswaramoorthy M, Buée L, Cassel JC, Giacobini P, Blum D, Merienne K, Kundu TK, Boutillier AL. Neurobiol Dis. 2024 198: 106538 https://doi.org/10.1016/j.nbd.2024.106538
- Keep calm and carry H3K27me1 off. Alcalá-Vida R, Barco A. Neuron 2024 112(17): 2829-2832 https://doi.org/10.1016/j.neuron.2024.07.014
- Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes. Tzeplaeff L, Seguin J, Le Gras S, Megat S, Cosquer B, Plassard D, Dieterlé S, Paiva I, Picchiarelli G, Decraene C, Alcala-Vida R, Cassel JC, Merienne K, Dupuis L, Boutillier AL. Prog Neurobiol. 2023 227: 102483 https://doi.org/10.1016/j.pneurobio.2023.102483
- Altered activity-regulated H3K9 acetylation at TGF-beta signaling genes during egocentric memory in Huntington’s disease. Alcalá-Vida R, Lotz C, Brulé B, Seguin J, Decraene C, Awada A, Bombardier A, Cosquer B, Pereira de Vasconcelos A, Brouillet E, Cassel JC, Boutillier AL, Merienne K. Prog Neurobiol. 2022 219: 102363 https://doi.org/10.1016/j.pneurobio.2022.102363
- Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice. Pupak A, Singh A, Sancho-Balsells A, Alcalá-Vida R, Espina M, Giralt A, Martí E, Ørom UAV, Ginés S, Brito V. Cell Mol Life Sci. 2022 79(8): 416 https://doi.org/10.1007/s00018-022-04444-6
- Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats. De Sa Nogueira D, Bourdy R, Alcala-Vida R, Filliol D, Andry V, Goumon Y, Zwiller J, Romieu P, Merienne K, Olmstead MC, Befort K. Mol Neurobiol. 2022 59(3): 1896-1911 https://doi.org/10.1007/s12035-022-02722-9
- Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice. Alcalá-Vida R, Seguin J, Lotz C, Molitor AM, Irastorza-Azcarate I, Awada A, Karasu N, Bombardier A, Cosquer B, Skarmeta JLG, Cassel JC, Boutillier AL, Sexton T, Merienne K. Nat Commun. 2021 12(1): 364 https://doi.org/10.1038/s41467-020-20605-2
- Epigenetic mechanisms underlying enhancer modulation of neuronal identity, neuronal activity and neurodegeneration. Alcalà-Vida R, Awada A, Boutillier AL, Merienne K. Neurobiol Dis. 2021 147: 105155 https://doi.org/10.1016/j.nbd.2020.105155
- Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease. Alcalá-Vida R, Garcia-Forn M, Castany-Pladevall C, Creus-Muncunill J, Ito Y, Blanco E, Golbano A, Crespí-Vázquez K, Parry A, Slater G, Samarajiwa S, Peiró S, Di Croce L, Narita M, Pérez-Navarro E. EMBO Mol Med. 2021 13(2): e12105 https://doi.org/10.15252/emmm.202012105
- Increased Levels of Rictor Prevent Mutant Huntingtin-Induced Neuronal Degeneration. Creus-Muncunill J, Rué L, Alcalá-Vida R, Badillos-Rodríguez R, Romaní-Aumedes J, Marco S, Alberch J, Perez-Otaño I, Malagelada C, Pérez-Navarro Mol Neurobiol. 2018 55(10): 7728-7742 https://doi.org/10.1007/s12035-018-0956-5
- Chelerythrine promotes Ca2+-dependent calpain activation in neuronal cells in a PKC-independent manner. Saavedra A, Fernández-García S, Cases S, Puigdellívol M, Alcalá-Vida R, Martín-Flores N, Alberch J, Ginés S, Malagelada C, Pérez-Navarro E. Biochim Biophys Acta Gen Subj. 2017 1861(4): 922-935 https://doi.org/10.1016/j.bbagen.2017.01.021
- Targeting CAG repeat RNAs reduces Huntington’s disease phenotype independently of huntingtin levels. Rué L, Bañez-Coronel M, Creus-Muncunill J, Giralt A, Alcalá-Vida R, Mentxaka G, Kagerbauer B, Zomeño-Abellán MT, Aranda Z, Venturi V, Pérez-Navarro E, Estivill X, Martí E. J Clin Invest. 2016 126(11): 4319-4330 https://doi.org/10.1172/jci83185
- Early down-regulation of PKCδ as a pro-survival mechanism in Huntington’s disease. Rué L, Alcalá-Vida R, López-Soop G, Creus-Muncunill J, Alberch J, Pérez-Navarro E. Neuromolecular Med. 2014 16(1): 25-37 https://doi.org/10.1007/s12017-013-8248-8
Rafael Alcalá Vida