Personal
Jose Carlos Pastor Pareja

Group

• Cell-to-tissue architecture in the nervous system
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Programs

• Genetic & epigenetic basis of Individuality & aging
• Neural stem cell regulation and differentiation

Projects

• Architecture of the Secretory Pathway and Secretory-Endolysosomal Coordination in Neurons

Articles

• Cooperative definition of ER exit sites by Tango1, Sec16 and Sec12. Zhi Feng, Mercedes Martín , Marta Rojas , José Carlos Pastor-Pareja* J Cell Sci. 2026 139: jcs.264950 https://doi.org/10.1242/jcs.264950
• Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila. Ramongolalaina C, Pastor-Pareja JC, Zhang E, Jia Y. Nucl Acids Res. 2026 54: gkag244 https://doi.org/10.1093/nar/gkag244
• Tissue morphogenesis: Regional differences in basement membrane mechanics influence epithelial geometry. Martín M, Guarch E, Pastor-Pareja JC* Curr Biol. 2026 36: R249-R252 https://doi.org/10.1016/j.cub.2026.01.063
• Mechanical coupling between dorsal and ventral surfaces shapes the Drosophila haltere. Song Y, Martin P, Sun T, Fernandez-Herrero J, Sanchez-Herrero E and Pastor-Pareja, JC. Current Biology. 2025 https://doi.org/10.1016/j.cub.2025.05.040
• Three Decades of the Spanish Society for Developmental Biology (SEBD): Insights and Emerging Perspectives from the 18th Spanish Society for Developmental Biology Meeting (SEBD 2024). Herrera E, Acosta S, Almuedo M, Borrell V, Cañestro C, Casas-Tintó S, Escudero LM, Gorfinkiel N, Hoijman E, Pastor-Pareja JC, Pernaute B, Rayón T, Saade M, Solana J, Trivedi V, Martí E, Pujades C, Araújo SJ. Int. J. Dev. Biol. 2025 69: 1 - 9 (Meeting Report) https://doi.org/10.1387/ijdb.250034sa
• Towards a unified framework for the function of endoplasmic reticulum exit sites. Farhan H, Raote I, Campelo F, Ge L, Hirschberg K, Forrester A, Zanetti G, Lippincott-Schwartz J, Pastor-Pareja JC, Perez F, Saito K and Malhotra V. Nat Rev Mol Cell Biol. 2025 29 Sept. https://doi.org/10.1038/s41580-025-00899-0
• JNK signaling and integrins cooperate to maintain cell adhesion during epithelial fusion in Drosophila. Karkali K, Pastor-Pareja JC, Martin-Blanco E. Front Cell Dev Biol. 2024 11: 1034484 https://doi.org/10.3389/fcell.2023.1034484
• p24–Tango1 interactions ensure ER–Golgi interface stability and efficient transport. Yang K, Feng Z, Pastor-Pareja JC*. J Cell Biol. 2024 223: e202309045 https://doi.org/10.1083/jcb.202309045
• Stay in touch with the endoplasmic reticulum. Sha Sun, Gan Zhao, Mingkang Jia, Qing Jiang, Shulin Li, Haibin Wang, Wenjing Li, Yunyun Wang, Xin Bian, Yan G. Zhao, Xun Huang, Ge Yang, Huaqing Cai, Jose C. Pastor-Pareja, Liang Ge, Chuanmao Zhang & Junjie Hu Science China Life Sciences. 2024 67: 230–257 https://doi.org/10.1007/s11427-023-2443-9
• Collagen IV of basement membranes: IV. Adaptive mechanism of collagen IV scaffold assembly in Drosophila. Jacob A. Summers, Madison Yarbrough, Min Liu, W. Hayes McDonald, Billy G. Hudson, José C. Pastor-Pareja, Sergei P. Boudko J. Biol. Chem. 2023 299 (12): 105394 https://doi.org/10.1016/j.jbc.2023.105394
• Convergence of secretory, endosomal, and autophagic routes in trans-Golgi-associated lysosomes. Zhou, L., Xue, X., Yang, K., Feng, Z., Liu, M., Pastor-Pareja, J.C. J Cell Biol. 2023 222(1):e202203045 https://doi.org/10.1083/jcb.202203045
• FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila. Lei Y , Huang Y, Yang K, Cao X, Song Y, Martín-Blanco E, Pastor-Pareja JC PLoS Biol. 2023 21: e3002050 https://doi.org/10.1371/journal.pbio.3002050
• Intrinsic and damage-induced JAK/STAT signaling regulate developmental timing by the Drosophila prothoracic gland. Cao X, Rojas M, Pastor-Pareja JC. Dis Mod Mech. 2022 15: dmm049160 https://doi.org/10.1242/dmm.049160
• Atypical laminin spots and pull-generated microtubule-actin projections mediate Drosophila wing adhesion Sun T, Song Y, Teng D, Chen Y, Dai J, Ma M, Zhang W, Pastor-Pareja JC Cell Rep. 2021 36:109667 https://doi.org/10.1016/j.celrep.2021.109667
• ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers Yang K, Liu M, Feng Z, Rojas M, Zhou L, Ke H, Pastor-Pareja JC Cell Rep. 2021 36:109707 https://doi.org/10.1016/j.celrep.2021.109707
• Katanin p60-like 1 sculpts the cytoskeleton in mechanosensory cilia Sun L, Cui L, Liu Z, Wang Q, Xue Z, Wu M, Sun T, Mao D, Ni J-Q, Pastor-Pareja JC, Liang X. J Cell Biol. 2021 220: e202004184 https://doi.org/10.1083/jcb.202004184
• Tales of the ER-Golgi Frontier: Drosophila-Centric Considerations on Tango1 Function. Feng Z, Yang K, Pastor-Pareja JC. Front Cell Dev Biol. 2021 8: 619022 - Review https://doi.org/10.3389/fcell.2020.619022
• Atypical basement membranes and basement membrane diversity – what is normal anyway?. Pastor-Pareja JC. J Cell Sci. 2020 133: jcs241794 - Review https://doi.org/10.1242/jcs.241794
• Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner. Chen Y, sun T, bi Z, Ni J-Q, Pastor-Pareja JC, Javid B. Sci Rep. 2020 10: 8485 https://doi.org/10.1038/s41598-020-65348-8
• Spectraplakin Shot maintains perinuclear microtubule organization in Drosophila polyploid cells Sun T, Song Y, Dai J, Mao D, Ma M, Ni J-Q, Liang X, Pastor-Pareja JC Dev Cell 2019 49:731-747.e7 https://doi.org/10.1016/j.devcel.2019.03.027
• Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirements. Ke H, Feng Z, Liu M, Sun T, Dai J, Ma M, Liu L-P, Ni J-Q, Pastor-Pareja JC. J Genet Genom. 2018 45: 299-313 https://doi.org/10.1016/j.jgg.2018.05.002
• Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly. Dai J , Estrada B, Jacobs S, Sánchez-Sánchez-B , Tang J, Ma M, Magadán-Corpas P, Pastor-Pareja JC , Martín-Bermudo MD. PLoS Genet. 2018 14: e1007483 https://doi.org/10.1371/journal.pgen.1007483
• The Drosophila Hox gene Ultrabithorax controls appendage shape by regulating extracellular matrix dynamics. de las Heras J, Garcia-Cortés C, Foronda D, Pastor-Pareja JC, Shashidhara LS, Sánchez-Herrero E. Development. 2018 145: dev161844 https://doi.org/10.1242/dev.161844
• Basement membrane manipulation in Drosophila wing discs affects Dpp retention but not growth mechanoregulation Ma M, Cao, Dai J, Pastor-Pareja JC Dev Cell  2017 42:97-106.e4 https://doi.org/10.1016/j.devcel.2017.06.004
• Inter-adipocyte Adhesion and Signaling by Collagen IV Intercellular Concentrations in Drosophila. Dai J, Ma M, Feng Z, Pastor-Pareja JC. Curr Biol. 2017 27: 2729-2740.e4 https://doi.org/10.1016/j.cub.2017.08.002
• Tango1 spatially organizes ER exit sites to control ER export Liu M, Feng Z, Ke H, Liu Y, Sun T, Dai J, Cui W, Pastor-Pareja JC J Cell Biol 2017 216:1035-1059 https://doi.org/10.1083/jcb.201611088
• Extracellular chloride signals Collagen IV network assembly to form basement membranes outside cells. Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Stothers C, Ero-Tolliver IA, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, McCall AS, Vanacore R, Gautam Bhave G, Santoro S, Blackwell T, Zent R, Pozzi A, Hudson BG. J Cell Biol. 2016 213 (4): 479–494 https://doi.org/10.1083/jcb.201510065
• Localized JNK signaling regulates organ size during development. Willsey HR, Zheng X, Pastor-Pareja JC, Willsey AJ, Beachy PA, Xu T. eLIFE 2016 5: e11491 https://doi.org/10.7554/eLife.11491
• Plasma membrane overgrowth causes fibrotic collagen accumulation and immune activation in Drosophila adipocytes. Zang Y§, Wan M§, Liu M, Ke H, Ma S, Liu LP, Ni JQ, Pastor-Pareja JC. eLIFE 2015 4: e07187 https://doi.org/10.7554/eLife.07187
• Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila. Wu C, Chen C, Dai JL, Zhang F, Chen Y, Li W, Pastor-Pareja JC, Xue L. Open Biol. 2015 5: 140717 https://doi.org/10.1098/rsob.140171

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