Personal
Guillermina López Bendito

Group

• Development, Plasticity and Reprogramming of Sensory Circuits
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Programs

• Building & adapting circuits into functional networks

Projects

• ERC-Patterns of Spontaneous Activity in the Assembly and Rewiring of Functional Sensory Circuits
• Mecanismos y Estructuras Implicadas en la Segregación Funcional de los Circuitos Sensoriales
• Fens-Hertie Winter School Grant
• PROMETEO: DEVELOPMENTAL PROGRAMS AND FUNCTIONAL IMPACT OF NEURON-ASTROCYTE INTERACTIONS IN SENSORY CIRCUIT FORMATION AND BEHAVIOR (DEVNEUROASTRO)
• Interacción entre la Actividad Espontánea y los Programas Genéticos en la Arealización Cortical de las Modalidades Sensoriales

Articles

• Thalamic Activity Regulates Interneuron Density in the Developing Visual Thalamus. Huerga-Gómez, I., Torres-Romero, D., Castellano-Ruiz, P., Wilson, E.S., Martini, F.J. and López-Bendito, G. J. Neuroscience. 2026 46(24): e0247252026 https://doi.org/10.1523/jneurosci.0247-25.2026
• A prenatal window for enhancing spatial resolution of cortical barrel maps. Aníbal-Martínez M, Puche-Aroca L, Pérez-Montoyo E, Pumo G, Madrigal MP, Rodríguez-Malmierca LM, Martini FJ, Rijli FM and López-Bendito G. Nature Communications. 2025 (print) https://doi.org/10.1038/s41467-025-57052-w
• Sensory modality-specific wiring of thalamocortical circuits. Guillamón-Vivancos T, Aníbal-Martínez M, Puche-Aroca L, Martini FJ, López-b Nat Rev Neurosci. 2025 Review; 26(10): 623-641 https://doi.org/10.1038/s41583-025-00945-y
• Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids. Eduardo Leyva-Díaz, Emily S. Wilson, Guillermina López-Bendito Cell Stem Cell. 2024 31(3): p283-284 https://doi.org/10.1016/j.stem.2024.02.008
• Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice. Ángela Rodríguez-Prieto, Isabel Mateos-White, Mar Aníbal-Martínez, Carmen Navarro-González, Cristina Gil-Sanz, Yaiza Domínguez-Canterla, Ana González-Manteiga, Verónica Del Buey Furió, Guillermina López-Bendito, Pietro Fazzari. Life Science Alliance. 2024 Volume 7, No. 9 https://doi.org/10.26508/lsa.202302250
• The superior colliculus: New insights into an evolutionarily ancient structure. Teresa Guillamón-Vivancos , Fabrizio Favaloro , Francesco Dori , Guillermina López-Bendito. Current Opinion in Neurobiology. 2024 89: December 2024, 102926 https://doi.org/10.1016/j.conb.2024.102926
• Building thalamic neuronal networks during mouse development. Huerga-Gómez I, Martini FJ, López-Bendito G. Front Neural Circuits. 2023 17: 1098913 https://doi.org/10.3389/fncir.2023.1098913
• Mesoscale calcium imaging in vivo: evolution and contribution to developmental neuroscience. Guillamón-Vivancos T, Vandael D, Torres D, López-Bendito G, Martini FJ. Front Neurosci. 2023 17: 1210199 https://doi.org/10.3389/fnins.2023.1210199
• Spontaneous Thalamic Activity Modulates the Cortical Innervation of the Primary Visual Nucleus of the Thalamus. Moreno-Juan, V., Aníbal-Martínez, M., Herrero-Navarro, Á., Valdeolmillos, M., Martini, F.J., López-Bendito, G. Neuroscience 2023 508: 87-97 https://doi.org/10.1016/j.neuroscience.2022.07.022
• Cross-Modal Plasticity in Brains Deprived of Visual Input Before Vision. López-Bendito, G., Aníbal-Martínez, M., Martini, F.J. Annu Rev Neurosci . 2022 45: 471-489 https://doi.org/10.1146/annurev-neuro-111020-104222
• Dynamic interplay between thalamic activity and Cajal-Retzius cells regulates the wiring of cortical layer 1. Genescu, I., Aníbal-Martínez, M., Kouskoff, V., Chenouard, N., Mailhes-Hamon, C., Cartonnet, H., Lokmane, L., Rijli, F.M., López-Bendito, G., Gambino, F., Garel, S. Cell Rep. 2022 39(2): 110667 https://doi.org/10.1016/j.celrep.2022.110667
• Input-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus Teresa Guillamón-Vivancos, Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Juan Antonio Moreno-Bravo, Miguel Valdeolmillos, Francisco J. Martini, Guillermina López-Bendito Science 2022 Aug 19; 377(6608):845-850 https://doi.org/10.1126/science.abq2960
• A unique bipartite Polycomb signature regulates stimulus-response transcription during development Kitazawa T, Machlab D, Joshi O, Maiorano N, Kohler H, Ducret S, Kessler S, Gezelius H, Soneson C, Papasaikas P, López-Bendito G, Stadler MB, Rijli FM Nat Genet 2021 53(3):379 https://doi.org/10.1038/s41588-021-00789-z
• Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation Alçada-Morais S, Gonçalves N, Moreno-Juan V, Andres B, Ferreira S, Marques JM, Magalhães J, Rocha JMM, Xu X, Partidário M, Cunha RA, López-Bendito G, Rodrigues RJ Cereb Cortex 2021 31(12):5652 https://doi.org/10.1093/cercor/bhab188
• Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming Herrero-Navarro Á, Puche-Aroca L, Moreno-Juan V, Sempere-Ferràndez A, Espinosa A, Susín R, Torres-Masjoan L, Leyva-Díaz E, Karow M, Figueres-Oñate M, López-Mascaraque L, López-Atalaya JP, Berninger B, López-Bendito G Sci Adv 2021 7(15):eabe8978 https://doi.org/10.1126/sciadv.abe8978
• Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons Company V, Andreu-Cervera A, Madrigal MP, Andrés B, Almagro-García F, Chédotal A, López-Bendito G, Martinez S, Echevarría D, Moreno-Bravo JA, Puelles E Front Cell Dev Biol 2021 9:682067 https://doi.org/10.3389/fcell.2021.682067
• Spontaneous activity in developing thalamic and cortical sensory networks Martini FJ,Guillamón-Vivancos T, Moreno-Juan V, Valdeolmillos M, López-Bendito G. Neuron 2021 109(16):2519 https://doi.org/10.1016/j.neuron.2021.06.026
• Netrin-1/DCC Signaling Differentially Regulates the Migration of Pax7, Nkx6.1, Irx2, Otp, and Otx2 Cell Populations in the Developing Interpeduncular Nucleus García-Guillén IM, Alonso A, Morales-Delgado N, Andrés B, Puelles L, López-Bendito G, Marín F, Aroca P Front Cell Dev Biol 2020 8:588851 https://doi.org/10.3389/fcell.2020.588851
• Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring Riva M, Genescu I, Habermacher C, Orduz D, Ledonne F, Rijli FM, López-Bendito G, Coppola E, Garel S, Angulo MC, Pierani A eLife 2019 8:e50503 https://doi.org/10.7554/eLife.50503
• Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice. Antón-Bolaños N, Sempere-Ferrandez A, Guillamon-Vivancos T, Martini FJ, Perez-Saiz L, Gezelius H, Filipchuk A, Valdeolmillos M, Lopez-Bendito G Science 2019 364(6444):987 https://doi.org/10.1126/science.aav7617
• Development of the Thalamocortical Interactions: Past, Present and Future Lopez-Bendito G Neuroscience 2018 385:67 https://doi.org/10.1016/j.neuroscience.2018.06.020
• Developmental interactions between thalamus and cortex: a true love reciprocal story Anton-Bolaños N, Espinosa A, Lopez-Bendito G Curr Opin Neurobiol 2018 52:33 https://doi.org/10.1016/j.conb.2018.04.018
• Developmental neuroscience (2018) Kolodkin AL, Lopez-BenditoG Curr Opin Neurobiol 2018 53:III https://doi.org/10.1016/j.conb.2018.https://doi.org/10.010
• Impact of thalamocortical input on barrel cortex development Martini FJ, Moreno-Juan V, Filipchuk A, Valdeolmillos M, Lopez-Bendito G Neuroscience 2018 368:246 https://doi.org/10.1016/j.neuroscience.2017.04.005
• Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes Gezelius H, Moreno-Juan V, Mezzera C, Thakurela S, Rodriguez-Malmierca LM, Pistolic J, Benes V, Tiwari VK, Lopez-Bendito G Cereb Cortex 2017 27(11):5054 https://doi.org/10.1093/cercor/bhw290
• Prenatal thalamic waves regulate cortical area size prior to sensory processing Moreno-Juan V, Filipchuk A, Anton-Bolaños N, Mezzera C, Gezelius H, Andres B, Rodriguez-Malmierca L, Susin R, Schaad O, Iwasato T, Schüle R, Rutlin M, Nelson S, Ducret S, Valdeolmillos M, Rijli FM, Lopez-Bendito G Nat Commun 2017 8:14172 https://doi.org/10.1038/ncomms14172
• Thalamic neuronal specification and early circuit formation Gezelius H, Lopez-Bendito G Dev Neurobiol 2017 77(7):830 https://doi.org/10.1002/dneu.22460
• Balancing family with a successful career in neuroscience Poirazi P, Belin D, Gräff J, Hanganu-Opatz IL, Lopez-Bendito G Eur J Neurosci 2016 44(2):1797 https://doi.org/10.1111/ejn.13280
• Cross-modal plasticity in sensory deprived animal models: From the thalamocortical development point of view Mezzera C, Lopez-Bendito G J Chem Neuroanat 2016 75:32 https://doi.org/10.1016/j.jchemneu.2015.09.005
• Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion Moreno-Bravo JA, Martinez-Lopez JE, Madrigal MP, Kim M, Mastick GS, Lopez-Bendito G, Martinez S, Puelles E Brain Struct Funct 2016 221(1):665 https://doi.org/10.1007/s00429-014-0932-4
• Getting published: how to write a successful neuroscience paper Schwabe L, Lopez-Bendito G, Ribeiro C Eur J Neurosci 2016 43(8):992 https://doi.org/10.1111/ejn.13215
• Moving on: mobility for early-career neuroscientists Grubb MS, Hoogenraad CC, Schwabe L, Lopez-Bendito G Eur J Neurosci 2016 44(6):2285 https://doi.org/10.1111/ejn.13339
• Antagonistic Effects of BACE1 and APH1B-gamma-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse Barao S, Gartner A, Leyva-Diaz E, Demyanenko G,Munck S, Vanhoutvin T, Zhou L, Schachner M, Lopez-Bendito G, Maness PF, De Strooper B Cell Rep 2015 12(9):1367 https://doi.org/10.1016/j.celrep.2015.07.059
• DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity Castillo-Paterna M, Moreno-Juan V, Filipchuk A, Rodriguez-Malmierca L, Susin R, Lopez-Bendito G EMBO Rep 2015 16(7):851 https://doi.org/10.15252/embr.201439882
• Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development Morello F, Prasad AA, Rehberg K, de Sa RV, Anton-Bolaños N, Leyva Diaz E, Adolfs Y, Tissir F, Lopez-Bendito G, Pasterkamp RJ J Neurosci 2015 35(42):14205 https://doi.org/10.1523/JNEUROSCI.1840-15.2015
• FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons Leyva-Diaz E, del Toro D, Menal MJ, Cambray S, Susin R, Tessier-Lavigne M, Klein R, Egea J, Lopez-Bendito G Curr Biol 2014 24(5):494 https://doi.org/10.1016/j.cub.2014.01.042
• Inputs from the thalamocortical system on axon pathfinding mechanisms Garel S, Lopez-Bendito G Curr Opin Neurobiol 2014 27:143 https://doi.org/10.1016/j.conb.2014.03.013
• In and Out from the Cortex: Development of Major Forebrain Connections Leyva-Diaz E, Lopez-Bendito G Neuroscience 2013 254:26 https://doi.org/10.1016/j.neuroscience.2013.08.070
• Uncoupling of EphA/ephrinA signaling and spontaneous activity in neural circuit wiring Benjumeda I, Escalante A, Law C, Morales D, Chauvin G, Muca G, Coca Y, Lopez-Bendito G, Kania A, Martinez-Otero L, Herrera E J Neurosci 2013 33(46):18208 https://doi.org/10.1523/JNEUROSCI.1931-13.2013
• Cell replacement therapies for nervous system regeneration Lopez-Bendito G, Arlotta P Dev Neurobiol 2012 72(2):145 https://doi.org/10.1002/dneu.20897
• Development and plasticity of thalamocortical systems Jabaudon D, Lopez-Bendito G Eur J Neurosci 2012 35(10):1522 https://doi.org/10.1111/j.1460-9568.2012.08117.x
• Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain Molnar Z, Garel S, Lopez-Bendito G, Maness P, Price DJ Eur J Neurosci 2012 35(10):1573 https://doi.org/10.1111/j.1460-9568.2012.08119.x
• Shaping brain connections through spontaneous neural activity Yamamoto N, Lopez-Bendito G Eur J Neurosci 2012 35(10):1595 https://doi.org/10.1111/j.1460-9568.2012.08101.x
• Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth Mire E, Mezzera C, Leyva-Diaz E, Paternain AV, Squarzoni P, Bluy L, Castillo-Paterna M, Lopez MJ, Peregrin S, Tessier-Lavigne M, Gare S, Galceran J, Lerma J, Lopez-Bendito G Nat Neurosci 2012 15(8):1134 https://doi.org/10.1038/nn.3160
• The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors Marcos-Mondejar P, Peregrin S, Li JY, Carlsson L, Tole S, Lopez-Bendito G J Neurosci 2012 32(13):4372 https://doi.org/10.1523/JNEUROSCI.5851-11.2012
• Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness Sanchez-Alcaniz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, Lopez-Bendito G, Stumm R, Marin O Neuron 2011 69(1):77 https://doi.org/10.1016/j.neuron.2010.12.006
• Emergent Growth Cone Responses to Combinations of Slit1 and Netrin 1 in Thalamocortical Axon Topography Bielle F, Marcos-Mondejar P, Leyva-Diaz E, Lokmane L, Mire E, Mailhes C, Keita M, Garcia N, Tessier-Lavigne M, Garel S, Lopez-Bendito G Curr Biol 2011 21(20):1748 https://doi.org/10.1016/j.cub.2011.09.008
• Fgfr3 Regulates Development of the Caudal Telencephalon Moldrich RX, Mezzera C, Holmes WM, Goda S, Brookfield SJ, Rankin AJ, Barr E, Kurniawan N, Dewar D, Richards LJ,Lopez-Bendito G, Iwata T Dev Dynam 2011 240(6):1586 https://doi.org/10.1002/dvdy.22636
• Slit2 Activity in the Migration of Guidepost Neurons Shapes Thalamic Projections during Development and Evolution Bielle F, Marcos-Mondejar P, Keita M, Mailhes C, Verney C, Nquyen Ba-Charvet K, Tessier-Lavigne M, Lopez-Bendito G, Garel S Neuron 2011 69(6):1085 https://doi.org/10.1016/j.neuron.2011.02.026

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