Personal
Félix Viana de la Iglesia

Group

• Sensory transduction and nociception (URL: https://in.umh-csic.es/group3906)

Programs

• Neurobiology of pain & inflammation

Projects

• CELLULAR AND MOLECULAR DIVERSITY OF THE MECHANO AND THERMORECEPTORS: ROLE IN THE PERIPHERAL AND CENTRAL MECHANISMS IN CHRONIC PAIN
• IDENTIFICACIÓN Y CARACTERIZACIÓN DE UNA NUEVA DIANA MOLECULAR DE LA RAPAMICINA
• MECANISMOS CELULARES Y MOLECULARES DEL DOLOR INDUCIDO POR QUIMIOTERAPIA: PREPARANDO EL CAMINO PARA LA PREVENCIÓN Y EL TRATAMIENTO

Articles

• The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons. Arcas JM, Oudaha K, González A, Fernández-Trillo J, Peralta FC, Castro-Marsal J, Poyraz S, Tabener F, Sala S, de la Peña E, gomis A, Viana F. British Journal of Pharmacology. 2024 First published: 13 May 2024 https://doi.org/10.1111/bph.16402
• Sex differences in thermoregulation in mammals: Implications for energy homeostasis. Carlos Fernández-Peña , Alfonso Reimúndez, Félix Viana, Victor M. Arce, Rosa Señarís. Front. Endocrinol. 2023 Sec. Neuroendocrine Science - Volume 14 (Review) https://doi.org/10.3389/fendo.2023.1093376
• The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature. Reimúndez, A., Fernández-Peña, C., Ordás, P., Hernández-Ortego, P., Gallego, R., Morenilla-Palao, C., Navarro, J., Martín-Cora, F., Pardo-Vázquez, J.L., Schwarz, L.A., Arce, V., Viana, F., Señarís, R. Acta Physiol (Oxf) . 2023 237(3): art. e13896 https://doi.org/10.1111/apha.13896
• TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy Marcotti, A., Fernández-Trillo, J., González, A., Vizcaíno-Escoto, M., Ros-Arlanzón, P., Romero, L., Vela, J. M., Gomis, A., Viana, F., & de la Peña, E Brain 2023 146 (2): 475-491 https://doi.org/10.1093/brain/awac273
• Origins of direction selectivity in the primate retina. Kim, Y.J., Peterson, B.B., Crook, J.D., Joo, H.R., Wu, J., Puller, C., Robinson, F.R., Gamlin, P.D., Yau, K.-W., Viana, F., Troy, J.B., Smith, R.G., Packer, O.S., Detwiler, P.B., Dacey, D.M. Nat Commun. 2022 13(1): art 2862 https://doi.org/10.1038/s41467-022-30405-5
• Validation of Six Commercial Antibodies for the Detection of Heterologous and Endogenous TRPM8 Ion Channel Expression. Hernández-Ortego, P., Torres-Montero, R., de la Peña, E., Viana, F., Fernández-Trillo, J. Int J Mol Sci. 2022 23(24): 16164 https://doi.org/10.3390/ijms232416164
• Constitutive phosphorylation as a key regulator of TRPM8 channel function Rivera B, Moreno C, Lavanderos B, Hwang JY, Fernández-Trillo J, Park KS, Orio P, Viana F, Madrid R, Pertusa M J Neurosci 2021 41(41):8475 https://doi.org/10.1523/JNEUROSCI.0345-21.2021
• Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits Ordás P, Hernández-Ortego P, Vara H, Fernández-Peña C, Reimúndez A, Morenilla-Palao C, Guadaño-Ferraz A, Gomis A, Hoon M, Viana F, Señarís R J Comp Neurol 2021 529(1):234 https://doi.org/10.1002/cne.24694
• Detecting Warm Temperatures Is a Cool Kind of Thing Gomez Del Campo A, Viana F Neuron 2020 106(5):712 https://doi.org/10.1016/j.neuron.2020.05.009
• Piezo2 mediates low-threshold mechanically-evoked pain in the cornea Fernández-Trillo J, Florez-Paz D, Iñigo-Portugués A, González-González O, Del Campo AG, González A, Viana F, Belmonte C, Gomis A J Neurosci 2020 40(47):8976 https://doi.org/10.1523/JNEUROSCI.0247-20.2020
• The immunosuppressant macrolide tacrolimus activates cold-sensing TRPM8 channels Miguel Arcas J, Gonzalez A, Gers-Barlag K, Gonzalez-Gonzalez O, Bech F, Demirkhanyan L, Zakharian E, Belmonte C, Gomis A, Viana F Journal of Neuroscience 2019 39(6):949 https://doi.org/10.1523/JNEUROSCI.1726-18.2018
• Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice Reimundez A, Fernandez-Peña C, Garcia G, Fernandez R, Ordas P, Gallego R, Pardo-Vazquez JL, Arce V, Viana F, Señaris R J Neurosci 2018 38(15):3643 https://doi.org/10.1523/JNEUROSCI.3002-17.2018
• Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis Señarís R, Ordás P, Reimúndez A, Viana F Pflugers Arch 2018 470(5):761 https://doi.org/10.1007/s00424-018-2145-9
• Morphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice Alcalde I, Íñigo-Portugués A, González-González O, Almaraz L, Artime E, Morenilla-Palao C, Gallar J, Viana F, Merayo-Lloves J, Belmonte C J Comp Neurol 2018 526(11):1859 https://doi.org/10.1002/cne.24454
• Nociceptors: thermal allodynia and thermal pain Viana, Felix THERMOREGULATION: FROM BASIC NEUROSCIENCE TO CLINICAL NEUROLOGY, PT I 2018 156:103 https://doi.org/10.1016/B978-0-444-63912-7.00006-0
• TRPA1 Channels Mediate Human Gingival Fibroblast Response to Phenytoin Lopez-Gonzalez MJ, Luis E, Fajardo O, Meseguer V, Gers-Barlag K, Niñerola S, Viana F J Dent Res 2017 96(7):832 https://doi.org/10.1177/0022034517695518
• New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives Lolignier S, Gkika D, Andersson D, Leipold E, Vetter I, Viana F, Noël J, Busserolles J J Neurosci 2016 36(45):11435 https://doi.org/10.1523/JNEUROSCI.2327-16.2016
• TRPA1 channels: molecular sentinels of cellular stress and tissue damage Viana, F J Physiol (London) 2016 594(15):4151 https://doi.org/10.1113/JP270935
• TRPM8 is a neuronal osmosensor that regulates eye blinking in mice Quallo T, Vastani N, Horridge E, Gentry C, Parra A, Moss S, Viana F, Belmonte C, Andersson DA, Bevan S Nat Commun 2015 6:7150 https://doi.org/10.1038/ncomms8150
• Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain Pertusa M, Gonzalez A, Hardy P, Madrid R, Viana F J Biol Chem 2014 289(32):21828 https://doi.org/10.1074/jbc.M114.565994
• Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation Morenilla-Palao C, Luis E, Fernandez-Peña C, Quintero E, Weaver JL, Bayliss DA, Viana F Cell Rep 2014 8(5):1571 https://doi.org/10.1016/j.celrep.2014.08.003
• Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications Török Z, Crul T, Maresca B, Schütz GJ, Viana F, Dindia L, Piotto S, Brameshuber M, Balogh G, Peter M, Porta A, Trapani A, Gombos I, Glatz A, Gungor B, Peksel B, Vigh L Jr, Csoboz B, Horvath I, Vijayan MM, Hooper PL, Harwood JL, Vigh L Biochim Biophys Acta-Biomembranes 2014 1838(6):1594 https://doi.org/10.1016/j.bbamem.2013.12.015
• TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins Meseguer V, Alpizar YA,Luis E, Tajada S, Denlinger B, Fajardo O, Manenschijn JA, Fernandez-Peña C,Talavera A, Kichko T, Navia B, Sanchez A, Señaris R, Reeh P,Perez-Garcia MT, Lopez-Lopez JR, Voets T, Belmonte C, Talavera K, Viana F Nat Commun 2014 5:3125 https://doi.org/10.1038/ncomms4125
• N-Glycosylation of TRPM8 Ion Channels Modulates Temperature Sensitivity of Cold Thermoreceptor Neurons Pertusa M, Madrid R, Morenilla-Palao C, Belmonte C, Viana F J Biol Chem 2012 287(22):18218 https://doi.org/10.1074/jbc.M111.312645
• Role of Ih in the firing pattern of mammalian cold thermoreceptor endings Orio P, Parra A, Madrid R, Gonzalez O, Belmonte C, Viana F J Neurophysiol 2012 108(11):3009 https://doi.org/10.1152/jn.01033.2011
• The Influence of Cold Temperature on Cellular Excitability of Hippocampal Networks de la Peña E, Mälkiä A, Vara H, Caires R, Ballesta JJ, Belmonte C, Viana F PLoS ONE 2012 7(12):e52475 https://doi.org/10.1371/journal.pone.0052475
• TRPM8 Ion Channels Differentially Modulate Proliferation and Cell Cycle Distribution of Normal and Cancer Prostate Cells Valero MLI, Mello de Queiroz F, Stuhmer W, Viana F, Pardo LA PLoS ONE 2012 7(12):e51825 https://doi.org/10.1371/journal.pone.0051825
• Chemosensory Properties of the Trigeminal System Viana F ACS Chem Neurosci 2011 2(1):38 https://doi.org/10.1021/cn100102c
• Membrane-tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity Valente P, Fernandez-Carvajal A, Camprubi-Robles M, Gomis A, Quirce S, Viana F, Fernandez-Ballester G, Gonzalez-Ros JM, Belmonte C, Planells-Cases R, Ferrer-Montiel A FASEB J 2011 25(5):1628 https://doi.org/10.1096/fj.10-174433
• Pharmacological and functional properties of TRPM8 channels in prostate tumor cells Valero M, Morenilla-Palao C, Belmonte C, Viana F Pflugers Arch 2011 461(1):99 https://doi.org/10.1007/s00424-010-0895-0
• The Emerging Pharmacology of TRPM8 Channels: Hidden Therapeutic Potential Underneath a Cold Surface Mälkiä A, Morenilla-Palao C, Viana F Curr Pharm Biotechnol 2011 12(1):54 https://doi.org/10.2174/138920111793937916
• Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea Parra A, Madrid R, Echevarria D, Del Olmo S, Morenilla-Palao C, Acosta MC, Gallar J, Dhaka A, Viana F, Belmonte C Nat Med 2010 16(12):1396 https://doi.org/10.1038/nm.2264

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