Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

Morenilla-Palao C, Luis E, Fernandez-Peña C, Quintero E, Weaver JL, Bayliss DA, Viana F
Magazine Cell Rep
Year 2014
Vol: Pages(start-end) 8(5):1571

Animals sense cold ambient temperatures through the activation of peripheral thermoreceptors tuned to different temperatures. These receptors express TRPM8, a cold- and menthol-activated cation channel. In this study, Morenilla-Palao et al. used FACS techniques to purify TRPM8-expressing neurons and described their ion channel transcriptome. They show that cold thermoreceptors are highly enriched in TASK-3 leak potassium channels. Genetic or pharmacological inactivation of TASK-3 channels increased the excitability of thermoreceptors and decreased the cold pain threshold of living mice.

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