Translational research of neurological and psychiatric disorders
The ultimate purpose of this program is to improve and alleviate the health of patients with neurological and psychiatric disorders. The program stands out for its translational vocation and the inclusion of sex/gender and age as key factors interacting with diseases onset, evolution, and potential treatments. The program includes several multidisciplinary approaches such as the design of animal models of psychiatric, neurological and addictive disorders to identify the brain circuits affected as well as novel targets (genetic and/or pharmacological) that may serve as the basis for the design of future clinical trials potentially patentable. Furthermore, induced stem cells obtained from patients and differentiated into neurons will be used to decipher the mechanism affected by the pathology and investigate potential therapies. Likewise, this research program aims to define functional biomarkers of neurological and psychiatric disorders and associate them with specific interventions with therapeutic value.
Research Groups
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Altered molecular mechanism in Alzheimer’s disease and dementia (PI: J. Sáez-Valero; MS. García-Ayllón)
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Neurobiology of mental, neurodegenerative and neuro-oncological diseases (PI: S. Martínez;D. Echevarria; E. de Puelles; E. Geijo)
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Neuropharmacology, Molecular Immunobiology and Behavior (PI: T. Femenía)
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Plasticity of Brain Networks (PI: S. Canals; E. Marcos)
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Translational Imaging Biomarkers (PI: S. De Santis)
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Translational neuropsychopharmacology of neurological and psychiatric diseases (PI: J. Manzanares)