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Lines of investigation
Our group aims to understand how behaviors emerge from the combinatorial activity of neural networks. We focus on the study of sensory integration and decision-making processes using as a model the gustatory system of Drosophila melanogaster, due to its accessibility to image, manipulate genetically and ease to study its behavioural output. The laboratory uses a mix of neural tracing techniques, in vivo calcium imaging, immunohistochemistry and behaviour analysis to decipher how genes and neurons shape animal behavior.
Representative Publications
- Molecular characterization of gustatory second-order neurons reveals integrative mechanisms of gustatory and metabolic information. Mollá-Albaladejo R, Jiménez-Caballero M and Sánchez-Alcañiz JA#. # Corresponding author. bioRxiv. 2024 in press; 2024 https://doi.org/10.1101/2024.06.17.598832
- Evolution of chemosensory tissues and cells across ecologically diverse Drosophila. Bontonou G, Saint-Leandre B, Kafle T, Baticle T, Hassan A, Sánchez-Alcañiz JA and Arguello RJ. Nature Communications. 2024 15, 1047 (2024) https://doi.org/10.1038/s41467-023-44558-4
- An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing Sánchez-Alcañiz JA, Silbering AF, Croset V, Zappia G, Sivasubramaniam AK, Abuin L, Sahai SY, Münch D, Steck K, Auer TO, Cruchet S, Neagu-Maier GL, Sprecher SG, Ribeiro C, Yapici N, Benton R. Nat Commun 2018 9(1):4252 https://doi.org/10.1038/s41467-018-06453-1
- A mechanosensory receptor required for food texture detection in Drosophila Juan Antonio Sánchez-Alcañiz , Giovanna Zappia , Frédéric Marion-Poll , Richard Benton Nat Commun 2017 8:14192 https://doi.org/10.1038/ncomms14192
- Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons Bartolini G, Sanchez-Alcaniz JA, Osorio C, Valiente M, Garcia-Frigola C, Marin O Cell Rep 2017 18(5):1157 https://doi.org/10.1016/j.celrep.2016.12.089
Tenure-Track Scientist
Postdoctoral Researcher
- Molecular characterization of gustatory second-order neurons reveals integrative mechanisms of gustatory and metabolic information. Mollá-Albaladejo R, Jiménez-Caballero M and Sánchez-Alcañiz JA#. # Corresponding author. bioRxiv. 2024 in press; 2024 https://doi.org/10.1101/2024.06.17.598832
- Evolution of chemosensory tissues and cells across ecologically diverse Drosophila. Bontonou G, Saint-Leandre B, Kafle T, Baticle T, Hassan A, Sánchez-Alcañiz JA and Arguello RJ. Nature Communications. 2024 15, 1047 (2024) https://doi.org/10.1038/s41467-023-44558-4
- Behavior Individuality: A Focus on Drosophila melanogaster Molla-Albaladejo R, Sanchez-Alcaniz JA Front Physiol 2021 12:719038 https://doi.org/
- An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing Sánchez-Alcañiz JA, Silbering AF, Croset V, Zappia G, Sivasubramaniam AK, Abuin L, Sahai SY, Münch D, Steck K, Auer TO, Cruchet S, Neagu-Maier GL, Sprecher SG, Ribeiro C, Yapici N, Benton R. Nat Commun 2018 9(1):4252 https://doi.org/10.1038/s41467-018-06453-1
- A mechanosensory receptor required for food texture detection in Drosophila Juan Antonio Sánchez-Alcañiz , Giovanna Zappia , Frédéric Marion-Poll , Richard Benton Nat Commun 2017 8:14192 https://doi.org/10.1038/ncomms14192
- Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons Bartolini G, Sanchez-Alcaniz JA, Osorio C, Valiente M, Garcia-Frigola C, Marin O Cell Rep 2017 18(5):1157 https://doi.org/10.1016/j.celrep.2016.12.089
- Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness Sanchez-Alcaniz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, Lopez-Bendito G, Stumm R, Marin O Neuron 2011 69(1):77 https://doi.org/10.1016/j.neuron.2010.12.006
