Personal
Luis Miguel Gutiérrez Pérez
Group leader
-
Molecular mechanisms in neurosecretion
https://in.umh-csic.es/group3892
- The Role of Nicotinic Receptors on Ca2+ Signaling in Bovine Chromaffin Cells. Virginia González-Vélez ,Luis Miguel Gutiérrez and José Villanueva. Curr. Issues Mol. Biol. 2024 46(1): 808-820 https://doi.org/10.3390/cimb46010052
- α3β4 Acetylcholine Nicotinic Receptors Are Components of the Secretory Machinery Clusters in Chromaffin Cells. Villanueva, J., Criado, M., Giménez-Molina, Y., González-Vélez, V., Gil, A., Gutiérrez, L.M. Int J Mol Sci . 2022 23 (16): art. 9101 https://doi.org/10.3390/ijms23169101
- Vesicle Fusion as a Target Process for the Action of Sphingosine and Its Derived Drugs. Villanueva J, Gimenez-Molina Y, Davletov B, Gutiérrez LM Int J Mol Sci. 2022 23(3): art. 1086 Review https://doi.org/10.3390/ijms23031086
- Development of the hypersecretory phenotype in the population of adrenal chromaffin cells from prehypertensive SHRs Peña Del Castillo JG, Segura-Chama P, Rincón-Heredia R, Millán-Aldaco D, Giménez-Molina Y, Villanueva J, Gutiérrez LM, Hernández-Cruz A Pflugers Arch 2021 473(11):1775 https://doi.org/10.1007/s00424-021-02614-2
- Multiple sclerosis drug FTY-720 toxicity is mediated by the heterotypic fusion of organelles in neuroendocrine cells Gimenez-Molina Y, García-Martínez V, Villanueva J, Davletov B, Gutiérrez LM Scientifc Reports 2019 9(1):18471 https://doi.org/10.1038/s41598-019-55106-w
- Studies of the Secretory Machinery Dynamics by Total Internal Reflection Fluorescence Microscopy in Bovine Adrenal Chromaffin Cells Villanueva J, Gimenez-Molina Y, Gutierrez LM Sci Rep 2019 1860:379 https://doi.org/10.1007/978-1-4939-8760-3_25
- Emerging evidence for the modulation of exocytosis by signalling lipids Garcia-Martinez V, Gimenez-Molina Y, Villanueva J, Darios FD, Davletov B, Gutiérrez LM FEBS Lett 2018 592(21):3493 https://doi.org/10.1002/1873-3468.13178
- Modeling the influence of co-localized intracellular calcium stores on the secretory response of bovine chromaffin cells Felix-Martínez GJ, Gil A, Segura J, Villanueva J, Gutierrez LM Comput Biol Med 2018 100:165 https://doi.org/10.1016/j.compbiomed.2018.06.032
- Multiple Mechanisms Driving F-actin-Dependent Transport of Organelles to and From Secretory Sites in Bovine Chromaffin Cells Gimenez-Molina Y, Villanueva J, Frances MDM, Viniegra S, Gutiérrez LM Front Cell Neurosci 2018 12:344 https://doi.org/10.3389/fncel.2018.00344
- The role of F-actin in the transport and secretion of chromaffin granules: an historic perspective Gutierrez LM, Villanueva J Pflugers Arch 2018 470(1):181 https://doi.org/10.1007/s00424-017-2040-9
- Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion Darios FD, Jorgacevski J, Flašker A, Zorec R, Garcia-Martinez V, Villanueva J, Gutierrez LM, Leese C, Bal M, Nosyreva E, Kavalali ET, Davletov B Sci Rep 2017 7:5958 https://doi.org/10.1038/s41598-017-05948-z
- The Differential Organization of F-Actin Alters the Distribution of Organelles in Cultured When Compared to Native Chromaffin Cells Gimenez-Molina Y, Villanueva J, Nanclares C, Lopez-Font I, Viniegra S, Frances MDM, Gandia L, Gil A, Gutierrez LM Front Cell Neurosci 2017 11:135 https://doi.org/10.3389/fncel.2017.00135
- Understanding the Role of Mitochondria Distribution in Calcium Dynamics and Secretion in Bovine Chromaffin Cells Gil, Amparo; Gonzalez-Velez, Virginia; Villanueva, Jose; Gutierrez, Luis M. Modeling Cellular Systems 2017 11:107 https://doi.org/10.1007/978-3-319-45833-5_5
- Captivating New Roles of F-Actin Cortex in Exocytosis anc Bulk Endocytosis in Neurosecretory Cells Meunier FA, Gutierrez LM Trends Neurosci 2016 39(9):605 https://doi.org/10.1016/j.tins.2016.07.003
- F-actin cytoskeleton and the fate of organelles in chromaffin cells Villanueva J, Gimenez-Molina Y, Viniegra S, Gutierrez LM J Neurochem 2016 137(6):860 https://doi.org/10.1111/jnc.13560
- Sphingomyelin derivatives increase the frequency of microvesicle and granule fusion in chromaffin cells Garcia-Martinez V, Montes MA, Villanueva J, Gimenez-Molina Y, De Toledo GA, Gutierrez LM Neuroscience 2015 295:117 https://doi.org/10.1016/j.neuroscience.2015.03.036
- A theoretical study of factors influencing calcium-secretion coupling in a presynaptic active zone model Gil A, Gonzalez-Velez V, Segura J, Gutierrez LM Math Biosci Eng 2014 11(5):1027 https://doi.org/10.3934/mbe.2014.11.1027
- Role of Protease-Activated Receptor 2 in Lung Injury Development During Acute Pancreatitis in Rats de-Madaria E, del Mar Frances M, Gea-Sorli S, Gutierrez LM, Viniegra S, Perez-Mateo M, Closa D, Lopez-Font I Pancreas 2014 43(6):895 https://doi.org/10.1097/MPA.0000000000000152
- The position of mitochondria and ER in relation to that of the secretory sites in chromaffin cells Villanueva J, Viniegra S, Gimenez-Molina Y, Garcia-Martinez V, Exposito-Romero G, del Mar Frances M, Garcia-Sancho J, Gutierrez LM J Cell Sci 2014 127(23):5105 https://doi.org/10.1242/jcs.160242
- Cortical F-Actin affects the localization and dynamics of SNAP-25 membrane clusters in chromaffin cells Torregrosa-Hetland CJ, Villanueva J, Garcia-Martinez V, Exposito-Romero G, Frances MDM, Gutierrez LM Int J Biochem Cell Biol 2013 45(3):583 https://doi.org/10.1016/j.biocel.2012.11.021
- Lipid Metabolites Enhance Secretion Acting on SNARE Microdomains and Altering the Extent and Kinetics of Single Release Events in Bovine Adrenal Chromaffin Cells Garcia-Martinez V, Villanueva J, Torregrosa-Hetland C, Bittman R, Higdon A, Darley-Usmar VM, Davletov B, Gutierrez LM PLoS One 2013 8(9):UNSP e75845 https://doi.org/10.1371/journal.pone.0075845
- F-Actin-Myosin II Inhibitors Affect Chromaffin Granule Plasma Membrane Distance and Fusion Kinetics by Retraction of the Cytoskeletal Cortex Villanueva J, Torres V, Torregrosa-Hetland CJ, Garcia-Martinez V, Lopez-Font I, Viniegra S, Gutierrez LM J Mol Neurosci 2012 48(2):328 https://doi.org/10.1007/s12031-012-9800-y
- Neurite extensions in chromaffin cells: study of the influence of the cytoskeletal structure on calcium dynamics and secretion Gil A, Torregrosa-Hetland CJ, Gonzalez-Velez V, Villanueva J, Garcia-Martinez V, Viniegra S, Segura J, Gutierrez LM Front Life Sci 2012 6:61 https://doi.org/10.1080/21553769.2012.745452
- New insights into the role of the cortical cytoskeleton in exocytosis from neuroendocrine cells Gutierrez LM Int Rev Cell Mol Biol 2012 295:109 https://doi.org/10.1016/B978-0-12-394306-4.00009-5
- The F-Actin Cortex in Chromaffin Granule Dynamics and Fusion: a Minireview Villanueva J, Torregrosa-Hetland CJ, Garcia-Martinez V, Frances MD, Viniegra S, Gutierrez LM J Mol Neurosci 2012 48(2):323 https://doi.org/10.1007/s12031-012-9718-4
- Calcium entry through slow-inactivating L-type calcium channels preferentially triggers endocytosis rather than exocytosis in bovine chromaffin cells Rosa JM, Torregrosa-Hetland CJ, Colmena I, Gutierrez LM, Garcia AG, Gandia L Am J Physiol-Cell Physiol 2011 301(1):C86 https://doi.org/10.1152/ajpcell.00440.2010
- Modeling F-actin cortex influence on the secretory properties of neuroendocrine cells Gutierrez LM, Gil A Commun Integr Biol 2011 4(4):413 https://doi.org/10.4161/cib.4.4.15251
- P2X7 Receptors Trigger ATP Exocytosis and Modify Secretory Vesicle Dynamics in Neuroblastoma Cells Gutierrez-Martin Y, Bustillo D,Gomez-Villafuertes R, Sanchez-Nogueiro J, Torregrosa-Hetland C, Binz T, Gutierrez LM, Miras-Portugal MT, Artalejo AR J Biol Chem 2011 286(13):11370 https://doi.org/10.1074/jbc.M110.139410
- The F-actin cortical network is a major factor influencing the organization of the secretory machinery in chromaffin cells Torregrosa-Hetland CJ, Villanueva J, Giner D, Lopez-Font I, Nadal A, Quesada I, Viniegra S, Exposito-Romero G, Gil A, Gonzalez-Velez V, Segura J, Gutierrez LM J Cell Sci 2011 124(5):727 https://doi.org/10.1242/jcs.078600
- alpha-Synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis Darios F, Ruiperez V, Lopez I, Villanueva J, Gutierrez LM, Davletov B EMBO Rep 2010 11(7):528 https://doi.org/10.1038/embor.2010.66
- Association of SNAREs and Calcium Channels with the Borders of Cytoskeletal Cages Organizes the Secretory Machinery in Chromaffin Cells Torregrosa-Hetland CJ, Villanueva J, Lopez-Font I, Garcia-Martinez V, Gil A, Gonzalez-Velez V, Segura J, Viniegra S, Gutierrez LM Cell Mol Neurobiol 2010 30(8):1315 https://doi.org/10.1007/s10571-010-9565-1
- Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis Lopez-Font I, Gea-Sorli S, De-Madaria E, Gutierrez LM, Perez-Mateo M, Closa D World J Gastroenterol 2010 16(27):3411 https://doi.org/10.3748/wjg.v16.i27.3411
- t-SNARE cluster organization and dynamics in chromaffin cells Lopez-Font I, Torregrosa-Hetland CJ, Villanueva J, Gutierrez LM J Neurochem 2010 114(6):1550 https://doi.org/10.1111/j.1471-4159.2010.06872.x
- The organization of the secretory machinery in chromaffin cells as a major factor in modeling exocytosis Villanueva J, Torregrosa-Hetland CJ, Gil A, Gonzalez-Velez V, Segura J, Viniegra S, Gutierrez LM HFSP J 2010 4(2):85 https://doi.org/10.2976/1.3338707
Luis Miguel Gutiérrez Pérez