Personal
José Vicente Sánchez Mut
Group leader
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Functional Epi-Genomics of Aging and Alzheimer’s Disease
https://in.umh-csic.es/group3886
- Huellas Moleculares hacia la Progresión y la Resistencia de la Enfermedad de Alzheimer
- Molecular Basis of Sleep Modulation of Alzheimers Disease Resilience (MOSAR)
- Sex-dependent interferon signaling contributes to female-biased vulnerability in Alzheimer’s disease. López-López V, Iniesta G, Galán-Ganga M, Expósito-Coca A, Durán-Laforet V, Bhojwani-Cabrera AM, Navarron CM, Guillot-Fernández M, Venero JL, Sánchez-Mut JV, Barco A, Giralt A, López-Atalaya JP. J Neuroinflammation. 2026 23, 217 https://doi.org/10.1186/s12974-026-03840-0
- The PM20D1-OLE pathway induces microglia rewiring to ameliorate Alzheimer disease. Pozzi-Ruiz, V., Giner de Gracia, A., Glauser, L., Romani, M., Gunter-Rahman, F., González-Ramón, A., Haj-Yahya, M., Kolla, R., Burns, A.M., Lashuel, H.A., Auwerx, J., Gräff, J. and Sanchez-Mut, J.V. Cell Death and Disease. 2026 https://doi.org/10.1038/s41419-026-08791-1
- Kdm1a safeguards the topological boundaries of PRC2-repressed genes and prevents aging-related euchromatinization in neurons. Del Blanco B, Niñerola S, Martín-González AM, Paraíso-Luna J, Kim M, Muñoz-Viana R, Racovac C, Sánchez-Mut JV, Ruan Y and Barco A. Nature Communications. 2024 15, 1781 (2024) https://www.nature.com/articles/s41467-024-45773-3
- A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment. Pérez, R.F., Tezanos, P., Peñarroya, A., González-Ramón, A., Urdinguio, R.G., Gancedo-Verdejo, J., Tejedor, J.R., Santamarina-Ojeda, P., Alba-Linares, J.J., Sainz-Ledo, L., Roberti, A., López, V., Mangas, C., Moro, M., Cintado, E., Muela, P., Rodríguez-Santamaría, M., Ortea, I., Iglesias-Rey, R., Castilla-Silgado, J., Tomás-Zapico, C., Iglesias-Gutiérrez, E., Sanchez-Mut, J.V., Trejo, J.L., Fernández, A.F. and Fraga, M.F. Nature Communications. 2024 15, art. 5829 https://www.nature.com/articles/s41467-024-49608-z#citeas
- Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer’s disease patients. Escamilla S, Badillos R, Comella JX, Solé M, Pérez-Otaño I, Sánchez Mut JV, Sáez-Valero J and Cuchillo-Ibáñez I. Alzheimer's & Dementia 2024 1-15 (in press) https://doi.org/10.1002/alz.14125
- PM20D1 is a quantitative trait locus associated with Alzheimer’s disease Sanchez-Mut JV,Heyn H, Silva BA, Dixsaut L, Garcia-Esparcia P, Vidal E, Sayols S, Glauser L, Monteagudo-Sánchez A, Perez-Tur J, Ferrer I, Monk D, Schneider B, Esteller M, Gräff Nat Med 2018 24(5):598 https://doi.org/10.1038/s41591-018-0013-y
- Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns Sanchez-Mut JV,Heyn H, Vidal E, Moran S, Sayols S, Delgado-Morales R, Schultz MD, Ansoleaga B Garcia-Esparcia P, Pons-Espinal M, Martinez de Lagran M, Dopazo J, Rabano A, Avila J, Dierssen M, Ira Lott, Ferrer I, Ecker JR, Esteller M Transl Psychiatry 2016 6(1):e718 https://doi.org/10.1038/tp.2015.214
- Epigenetic Alterations in Alzheimer’s Disease. Sanchez-Mut JV , Gräff J. Front Behav Neurosci 2015 0,6159722222 https://doi.org/10.3389/fnbeh.2015.00347
- Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer’s disease Jose Vicente Sanchez-Mut , Ester Aso, Holger Heyn, Tadashi Matsuda, Christoph Bock, Isidre Ferrer, Manel Esteller Hippocampus 2014 24(4):363 https://doi.org/ 10.1002/hipo.22245
- DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease Jose V Sanchez-Mut , Ester Aso, Nicolas Panayotis, Ira Lott, Mara Dierssen, Alberto Rabano, Rocio G Urdinguio, Agustin F Fernandez, Aurora Astudillo, Jose I Martin-Subero, Balazs Balint, Mario F Fraga, Antonio Gomez, Cecile Gurnot, Jean-Christophe Roux, Jesus Avila, Takao K Hensch, Isidre Ferrer, Manel Esteller Brain 2013 136(Pt 10):3018 https://doi.org/10.1093/brain/awt237
José Vicente Sánchez Mut