Personal
Juan Lerma

Group

• Synaptic Physiology (URL: https://in.umh-csic.es/group3888)

Programs

• Synaptic modulation of neural circuits and behavior

Projects

• KAINATE RECEPTOR OVEREXPRESSION AND BRAIN DISEASE
• (Finalizado) CENTROS DE EXCELENCIA SEVERO OCHOA 2018/2022

Articles

• Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum. Kakegawa W, Paternain AV, Matsuda K, Aller MI, Iida I, Miura E, Kazuya Nozawa K, Yamasaki T, Sakimura K, Yuzaki M and Lerma J. Cell Reports. 2024 in press https://doi.org/10.1016/j.celrep.2024.114427
• Exploring the Frontiers of Neuroscience: Highlights from the 11th IBRO World Congress (Editorial) Daniela Schiller, Juan Lerma Neuroscience. 2023 525, 10 August 2023, Pages 1-2 https://doi.org/10.1016/j.neuroscience.2023.07.007
• Adenosine A2A receptors control synaptic remodeling in the adult brain. Xu, X., Beleza, R.O., Gonçalves, F.Q., Valbuena, S., Alçada-Morais, S., Gonçalves, N., Magalhães, J., Rocha, J.M.M., Ferreira, S., Figueira, A.S.G., Lerma, J., Cunha, R.A., Rodrigues, R.J., Marques, J.M. Sci Rep. 2022 12(1): art 14690 https://doi.org/10.1038/s41598-022-18884-4
• Kainate receptors, homeostatic gatekeepers of synaptic plasticity Valbuena S, Lerma J Neuroscience 2021 19,01180556 https://doi.org/10.1016/j.neuroscience.2019.11.050
• Losing balance: Kainate receptors and psychiatric disorders comorbidities ValbuenaS, Lerma J Neuropharmacol 2021 191:108558 https://doi.org/10.1016/j.neuropharm.2021.108558
• Diffusion-weighted MRI in neurodegenerative and psychiatric animal models: experimental strategies and main outcomes Eed A, Cerdán Cerdá A, Lerma J, De Santis S J Neurosci Methods 2020 343:108814 https://doi.org/10.1016/j.jneumeth.2020.108814
• N-(7-(1H-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo Pharmacology. Møllerud S, Hansen RB, Pallesen J, Temperini P, Pasini D, Bornholt J, Nielsen B, Mamedova E, Chalupnik P, Paternain AV, Lerma J, Diaz-delCastillo M, Andreasen JT, Frydenvang K, Kastrup JS, Johansen TN, Pickering DS ACS Chem Neurosci 2019 10(11):4685 https://doi.org/10.1021/acschemneuro.9b00479
• Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model Valbuena S, García Á, Mazier W, Paternain AV, Lerma J Nature Communications 2019 10:4991 https://doi.org/10.1038/s41467-019-13004-9
• Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation Simões AP, Silva CG, Marques JM, Pochmann D, Porciuncula LO, Ferreira S, Oses JP, Beleza RO, Real JI, Köfalvi A, Bahr BA, Lerma J, Cunha RA, Rodrigues RJ Cell Death Dis 2018 3:297 https://doi.org/10.1038/s41419-018-0351-1
• Increased Grik4 Gene Dosage Causes Imbalanced Circuit Output and Human Disease-Related Behaviors Arora V, Pecoraro V, Aller MI, Roman C, Paternain AV, Lerma J Cell Rep 2018 23(13):3827 https://doi.org/10.1016/j.celrep.2018.05.086
• Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential Comune M, Rai A, Chereddy KK, Pinto S, Aday S, Ferreira AF, Zonari A, Blersch J, Cunha R, Rodrigues R, Lerma J, Simões PN, Preat V, Ferreira L J Control Release 2017 262:58 https://doi.org/10.1016/j.jconrel.2017.07.007
• NEW DEVELOPMENTS IN NEUROSCIENCE FOR 2017 Lerma J Neuroscience 2017 343:298 https://doi.org/10.1016/j.neuroscience.2016.12.022
• Non-canonical Signaling, the Hidden Life of Ligand-Gated Ion Channels Valbuena S, Lerma J Neuron 2016 92(2):316 https://doi.org/10.1016/j.neuron.2016.10.016
• Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches Izquierdo-Serra M, Bautista-Barrufet A, Trapero A, Garrido-Charles A, Diaz-Tahoces A, Camarero N, Pittolo S, Valbuena S, Perez-Jimenez A, Gay M, Garcia-Moll A, Rodriguez-Escrich C, Lerma J, de la Villa P, Fernandez E, Pericàs MÀ, Llebaria A, Gorostiza P Nat Commun 2016 7:12221 https://doi.org/10.1038/ncomms12221
• SERVING NEUROSCIENCE, SERVING IBRO, SERVING NEUROSCIENTISTS Lerma J Neuroscience 2016 312:260 https://doi.org/10.1016/j.neuroscience.2015.11.036
• Synaptic Targeting of Kainate Receptors Palacios-Filardo J, Aller MI, Lerma J Cereb Cortex 2016 26(4):1464 https://doi.org/10.1093/cercor/bhu244
• The Brain Prize 2016: A prize not to forget Lerma J Neuroscience 2016 321:vi https://doi.org/10.1016/j.neuroscience.2016.03.005
• A Proteomic Analysis Reveals the Interaction of GluK1 Ionotropic Kainate Receptor Subunits with Go Proteins Rutkowska-Wlodarczyk I, Aller MI, Valbuena S, Bologna JC, Prezeau L, Lerma J J Neurosci 2015 35(13):5171 https://doi.org/10.1523/JNEUROSCI.5059-14.2015
• Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features Aller MI, Pecoraro V, Paternain AV, Canals S, Lerma J J Neurosci 2015 35(40):13619 https://doi.org/10.1523/JNEUROSCI.2217-15.2015
• Epilog: Cajal’s unique and legitimated school Lerma J, De Carlos JA Front Neuroanat 2014 8:58 https://doi.org/10.3389/fnana.2014.00058
• Amelioration of ischemic brain damage by peritoneal dialysis, Godino MC, Romera VG, Sanchez-Tomero JA, Pacheco J, Canals S, Lerma J, Vivancos J, Moro MA, Torres M, Lizasoain I, Sanchez-Prieto J J Clin Invest 2013 123(10):4359 https://doi.org/10.1172/JCI67284
• CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation Marques JM, Rodrigues RJ, Valbuena S, Rozas JL, Selak S, Marin P, Aller MI, Lerma J J Neurosci 2013 33(46):18298 https://doi.org/10.1523/JNEUROSCI.3136-13.2013
• Kainate receptors in health and disease Lerma J, Marques JM Neuron 2013 80(2):292 https://doi.org/10.1016/j.neuron.2013.09.045
• Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth Mire E, Mezzera C, Leyva-Diaz E, Paternain AV, Squarzoni P, Bluy L, Castillo-Paterna M, Lopez MJ, Peregrin S, Tessier-Lavigne M, Gare S, Galceran J, Lerma J, Lopez-Bendito G Nat Neurosci 2012 15(8):1134 https://doi.org/10.1038/nn.3160
• Net(o) excitement for kainate receptors Lerma J Nat Neurosci 2011 14(7):808 https://doi.org/10.1038/nn.2864
• Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling Fazzari P, Paternain AV, Valiente M, Pla R, Lujan R, Lerma J, Marin O, Rico B Nature 2010 464(7293):1376 https://doi.org/10.1038/nature08928
• SNAP-25 Is a Target of Protein Kinase C Phosphorylation Critical to NMDA Receptor Trafficking Lau CG, Takayasu Y, Rodenas-Ruano A, Paternain AV, Lerma J, Bennett V, Zukin RS J Neurosci 2010 30(1):242 https://doi.org/10.1523/JNEUROSCI.4933-08.2010

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