drosophila                   Carmena lab

"Asymmetric division of neural stem cells in development and tumorigenesis"

Lab publications

Manzanero-Ortiz, S., de Torres-Jurado, A., Hernández-Rojas, R., Carmena, A. "Pilot RNAi Screen in Drosophila Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division" (2021). int. J. Mol. Sci. 22, 11332; doi.org/10.3390/ijms222111332  Article

Carmena, A. "Non-muscle myosin II activation: adding a classical touch to ROCK" (2021). Small GTPases 12(3), 161-166; doi.org/10.1080/21541248.2019.1671148  Article

Carmena, A. "The Case of the Scribble Polarity Module in Asymmetric Neuroblast Division in Development and Tunorigenesis" (2020). int. J. Mol. Sci. 21(8), 2865; doi:10.3390/ijms21082865  Article

Franco, M., Carmena, A. "Measurement of Mitotic Spindle Angle and Mitotic Cell Distance" (2019). Bio Protocol 9(22), e3432; doi:10.21769/BioProtoc.3432  Article

Franco, M., Carmena, A. "Eph signaling in mitotic spindle orientation: what's your angle here?" (2019). Cell cycle 18(20), 2590-2597; doi.org/10.1080/15384101.2019.1658479  Article

Franco, M., Carmena, A. "Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells" (2019). J Cell Biol 218(4), 1200-1217; doi: 10.1083/jcb.201807157  Article

Carmena, A. "Compromising asymmetric stem cell division in Drosophila central brain: Revisiting the connections with tumorigenesis" (2018). Fly 12(1), 71-80; doi: 10.1080/19336934.2017.1416277  Article

Rives-Quinto, N., Franco, M., De Torres-Jurado, A. and Carmena, A. "Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia" (2017). Development 144, 2570-2583; doi: 10.1242/dev.148171  Article

Keder, A., Rives-Quinto, N., Aerne, B.L., Franco, M., Tapon, N., and Carmena, A. “The Hippo Pathway Core Cassette Regulates Asymmetric Cell Division” (2015). Current Biology 25, 2739-2750; doi: dx.doi.org/10.1016/j.cub.2015.08.064  Article

Pérez-Gómez, R., Slováková, J., Rives-Quinto, N., Krejci, A. and Carmena, A. "A Serrate-Notch-Canoe complex mediates glial-neuroepithelial cell interactions essential during Drosophila optic lobe development" (2013). Journal of Cell Science 126(21), 4873-4884; doi: 10.1242/jcs.125617  Article

Keder, A. and Carmena, A. “Cytoplasmic protein motility and polarized sorting during asymmetric cell division” (2013). WIREs Developmental Biology 2, 797-808; doi: doi.org/10.1002/wdev.116  Article

Slováková, J., Speicher, S., Sánchez-Soriano, N., Prokop, A. and Carmena, A. “The Actin-Binding Protein Canoe/AF-6 Forms a Complex with Robo and Is Required for Slit-Robo Signaling during Axon Pathfinding at the CNS Midline” (2012). The Journal of Neuroscience 32(29), 10035-10044; doi: doi.org/10.1523/JNEUROSCI.6342-11.2012  Article

Carmena, A. “A big new job for small GTPases” (2012). Small GTPases 3(3), 1-4; doi: doi.org/10.1523/JNEUROSCI.6342-11.2012  Article

Carmena, A.*, Makarova, A. and Speicher, S. "The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation" (2011). The Journal of Cell Biology 195(4), 553-562; doi: doi.org/10.1083/jcb.201108112  Article
*corresponding author

Slováková, J. and Carmena, A. "Canoe/AF-6 functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions" (2011). Development 138, 1563-1571; doi: doi.org/10.1242/dev.056192  Article

Carmena, A. "Approaching Drosophila development through proteomic tools and databases: At the hub of the post-genomic era" (2009). Mechanisms of Development 126, 761-770; doi: doi.org/10.1016/j.mod.2009.08.001  Article

Carmena, A. "Signaling networks during development: the case of asymmetric cell division in the Drosophila nervous system" (2008). Developmental Biology 321, 1-17; doi: doi.org/10.1016/j.ydbio.2008.06.010  Article

Speicher, S., Fischer, A., Knoblich, J and Carmena, A. "The Drosophila PDZ Protein Canoe Regulates the Asymmetric Division of Neural and Muscle Progenitors" (2008). Current Biology 18, 831-837; doi: doi.org/10.1016/j.cub.2008.04.072  Article

Carmena, A.*, Speicher, S. and Baylies, M.K. "The PDZ protein Canoe/AF-6 Links Ras-MAPK, Notch and Wingless/Wnt Signaling Pathways by Directly Interacting with Ras, Notch and Dishevelled" (2006). PLoS ONE 1(1), e66; doi: doi.org/10.1371/journal.pone.0000066  Article
*corresponding author

Other publications

Carmena, A. and Baylies, M.K. "Development of the Larval Somatic Musculature" In "Muscle Development in Drosophila" (2005). Landes Bioscience. H. Sink editor. Article

Carmena, A., Buff, E., Halfon, M.S., Gisselbrecht, S., Jiménez, F., Baylies, M.K., and Michelson, A.M. "Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm" (2002). Developmental Biology 244, 226-242; doi: doi.org/10.1006/dbio.2002.0606  Article

Halfon, M.S., Carmena, A., Gisselbrecht, S., Sackerson, C.M., Jiménez, F., Baylies, M.K. and. Michelson, A.M. "Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors" (2000). Cell 103, 63-74; doi: doi.org/10.1016/S0092-8674(00)00105-7  Article

Carmena, A., Gisselbrecht, S., Harrison, J., Jiménez, F. and Michelson, A.M. "Combinatorial Signalling Codes for the Progressive Determination of Cell Fates in the Drosophila Embryonic Mesoderm" (1998). Genes & Development 12(24), 3910-3922; PMCID: PMC317272  Article

Buff, E., Carmena, A., Gisselbrecht, S., Jiménez, F. and Michelson, A.M. "Signaling by the Drosophila Epidermal Growth Factor Receptor is Required for the Specification and Diversification of Embryonic Muscle Progenitors" (1998). Development 125, 2075-2078; PMID: 9570772  Article

Speicher, S., García-Alonso, L., Carmena, A., Martín-Bermudo, M.D., de la Escalera S., Jiménez F. "Neurotactin Functions in Concert with Other Identified CAMs in Growth Cone Guidance in Drosophila" (1998). Neuron 20(2), 221-233; doi: doi.org/10.1016/S0896-6273(00)80451-1  Article

Carmena, A., Murugasu-Oei, B., Menon, D., Jiménez, F. and Chia, W. "inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis" (1998). Genes & Development 12, 304-315; PMCID: PMC316482  Article

Carmena, A., Bate, M. and Jiménez, F. "lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis" (1995). Genes & Development 9(19), 2373-2383; doi: doi.org/10.1101/gad.9.19.2373  Article

Martín-Bermudo, M.D.*, Carmena, A.* and Jiménez, F. "Neurogenic genes control gene expression at the transcriptional level in early neurogenesis and in mesectoderm specification" (1995) Development 121, 219-224. Article
* coauthors