Principal Investigator
Ph.D. Investigator
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Research Fields
Our laboratory investigates the molecular underpinnings of age-related cognitive decline and neurodegeneration, with a particular interest in Alzheimer’s disease (AD). We hypothesize that genetics, epigenetics, and the interaction of both – “neuro-epi-genetics” –, have long-lasting effects on brain function.
To tackle this hypothesis, we use mouse models and human samples, and combine molecular and behavioral neuroscience with state-of-the-art single-cell, next generation sequencing (NGS), bioinformatic tools and epi-genetic editing.
Our ultimate goal is to better understand age-related brain malfunctioning and to identify new biomarkers and targets to further develop current dementia-related therapies.
Representative Publications
Sanchez-Mut JV
,
Heyn H, Silva BA, Dixsaut L, Garcia-Esparcia P, Vidal E, Sayols S, Glauser L, Monteagudo-Sánchez A, Perez-Tur J, Ferrer I, Monk D, Schneider B, Esteller M, Gräff
"
PM20D1 quantitative trait locus is associated with Alzheimer’s disease.
"
Nat Med
.
24(5)
,
598
-
603
(
2018
)
Sanchez-Mut JV
,
Heyn H, Vidal E, Moran S, Sayols S, Delgado-Morales R, Schultz MD, Ansoleaga B Garcia-Esparcia P, Pons-Espinal M, Martinez de Lagran M, Dopazo J, Rabano A, Avila J, Dierssen M, Ira Lott, Ferrer I, Ecker JR, Esteller M
"
Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns.
"
Transl Psychiatry
.
6
,
(e718)
-
(
2016
)
Sanchez-Mut JV
,
Gräff J.
"
Epigenetic Alterations in Alzheimer's Disease.
"
Front Behav Neurosci
.
9
,
347
-
(
2015
)
Sanchez-Mut JV
,
Aso E, Heyn H, Matsuda T, Bock C, Ferrer I, Esteller M
"
Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.
"
Hippocampus
.
24(4)
,
363
-
8
(
2014
)
Sanchez-Mut JV
,
Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, Avila J, Hensch TK, Ferrer I, Esteller M
"
DNA Methylation Map of Mouse Brain Identifies Targets of Epigenetic Disruption in Alzheimer’s Disease.
"
Brain
.
136
,
3018
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27
(
2013
)
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