HomeAbout the InstituteResearch UnitsPeopleLinksPh.D ProgramEnglish Language Idioma EspañolWeb SearchIntranet Access
Research Group
Sensory-motor processing by subcortical areas
Unit Unit Cellular and Systems Neurobiology »

Principal Investigator Ph.D. Investigator Graduate students / Research Assistant Master Students
Research Fields
The basal ganglia are involved in a wide range of functions including decision-making, reward motor learning and selection motor sequences, all of which require integration of sensory and motor information. Problems in the basal ganglia function can generate numerous and diverse neurological disorders, for example: Parkinson’s and Huntington’s diseases, Tourette syndrome, obsessive-compulsive disorder, dystonia and also attention-deficit hyperactivity disorder (ADHD). The striatum (caudate nucleus & putamen) is the “door” or input layer of the basal ganglia that receives inputs from multiple cortical areas as prefrontal, motor or sensory, and thalamus. The striatum is best known for its role in planning and selecting motor sequences. But selection of proper motor sequences also requires the prioritizing of sensory information. Sensory information from different modalities such as tactile, visual, auditory or olfactory, all converge in the striatum. All of these simultaneous inputs have to be processed, filtered and integrated in order to select the appropriate ones. How striatal neurons process the information is largely unknown. We aim to study the role of the striatum in the sensory processing and its interplay with motor functions. To answer this question we use complementary electrophysiological, optical and anatomical methods.

Representative Publications

Alegre-Cortés J , Sáez M, Montanari R, Reig R. " Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum. " eLife . 10 , e60580 - DOI: 10.7554/eLife.60580 ( 2021 )

Sáez M , Ketzef M, Alegre-Cortés J, Reig R, Silberberg G. " A New Micro-holder Device for Local Drug Delivery during In Vivo Whole-cell Recordings. " Neuroscience . 318 , 115 - 123 ( 2018 )

Reig R. , Silberberg G. " Distinct Corticostriatal and Intracortical Pathways Mediate Bilateral Sensory Responses in the Striatum. " Cereb. Cortex . 26(12) , 4405 - 4415 ( 2016 )

Reig R , Zerlaut Y, Vergara R, Destexhe A, Sanchez-Vives MV. " Gain modulation of synaptic inputs by network state in auditory cortex in vivo " J. Neurosci . 35(6) , 2689 - 2702 ( 2015 )

Reig R , Silberberg G. Multisensory integration in the mouse striatum. " Multisensory integration in the mouse striatum. " Neuron . 83(5) , 1200 - 1212 ( 2014 )
Consejo Superior de Investigaciones Científicas
Universidad Miguel Hernández

Campus de San Juan | Sant Joan d’Alacant
Alicante | España

Tel. + 34 965 23 37 00
Fax + 34 965 91 95 61
© 2004-2020 Instituto de Neurociencias
Alicante | España | Legal Note |
Diseño web Digital Nature