HomeAbout the InstituteResearch UnitsPeopleLinksPh.D ProgramEnglish Language Idioma EspañolWeb SearchIntranet Access
Research Group
Development and assembly of bilateral neural circuits
Unit Unit Developmental Neurobiology »

Unit Click here to go to the Laboratory Website

Principal Investigator Ph.D. Investigator Graduate students / Research Assistant Master Students Technician Administration
Research Fields
The proper development and connectivity of an adult brain need the extension and guide of neuronal axons to their targets where they will establish appropriate synapses. We are interested in the molecular mechanisms underlying axon guidance and target recognition during the development of the nervous system. We focus on the binary decision of crossing or not the midline that many different types of axons must take at some point of their trajectory and how later they reach their final targets at both sides of the brain and once there, sensory information from both brain hemispheres is integrated and processed. Many features of mature neural function, including the interpretation of sensory information and the coordination of locomotion, depend on coherent communication between the two halves of the nervous system. Therefore, the correct formation of bilateral circuits is essential for the perfect functioning of the mature brain. To understand the mechanisms underlying the development of bilateral circuits our group applies a multidisciplinary set of approaches ranging from mouse genetics, anatomic studies and gene delivery in vivo and in vitro using the mouse visual system as a model.

Representative Publications

Morenilla-Palao C , López-Cascales MT, López-Atalaya JP, Baeza D, Calvo L, Barco A & Herrera E " A Zic2-regulated switch in a non-canonical Wnt/ß-catenin pathway is essential for the formation of bilateral circuits. " Science Advances . in press , - ( 2020 )

Murcia-Belmonte V , Coca Y, Vegar C, Negueruela S, de Juan C, Valiño A, da Silva R, Kania A, Martínez-Otero L, Borrell V, Erskine L, Herrera E " A retino-retinal projection guided by Unc5c emerged in species with retinal waves. " Current Biology . 29(7) , 1149 - 1160.e4 ( 2019 )

Fernández-Nogales M , Murcia-Belmonte V, Chen HY, Herrera E. " The peripheral eye: A neurogenic area with potential to treat retinal pathologies? " Progress in Retinal and Eye Research . 68 , 110 - 123 ( 2019 )

Marcucci F , Murcia-Belmonte V, Coca Y, Kuwajima T, Khalid S, Ferreiro S, Ross M, & Mason C*, Herrera E " The ciliary margin zone of the mammalian retina generates retinal ganglion cells. " Cell Reports . 17(12) , 3153 - 3164 ( 2016 )

Escalante E. , Murillo B, Morenilla-Palao C, Klar A and Herrera E. " Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS. " Neuron . 80 , 1392 - 1406 ( 2013 )
Consejo Superior de Investigaciones Científicas
Universidad Miguel Hernández

Campus de San Juan | Sant Joan d’Alacant
Alicante | España

Tel. + 34 965 23 37 00
Fax + 34 965 91 95 61
© 2004-2020 Instituto de Neurociencias
Alicante | España | Legal Note |
Diseño web Digital Nature