A gene regulatory network to control EMT programs in development and disease

Nature Communications 10, Article number: 5115
Publicado: 11 Nov 2019

Descubren un mecanismo que explica los problemas de orientación espacial en las personas con síndrome de Down

Nature Communications,
Publicado: 1 Noviembre 2019;

Descubren cómo se integra la información del embrión para que el corazón ocupe su posición final

Developmental Cell
https://doi.org/10.1016/j.devcel.2019.09.012
Publicado: 17 Octubre 2019

Researchers at the CSIC-UMH Neuroscience Institute discover molecules in unicellular organisms that are crucial for the organization of vertebrate tissues.

Molecular Biology and Evolution.
Published: 07 October 2019

Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus.

Nat Neurosci.
Publicado: 3 Septiembre 2019;

Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb

Cell Reports 28 (10), 2715–2727.e5
Publicado: 3 Septiembre 2019

Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.

eLife
Publicado: 15 Mayo 2019

Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice.

Science
Publicado: 2 Mayo 2019

Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence.

JAMA Psychiatry
Publicado: 3 Abril 2019

A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves.

Current Biology.
Published: 2019 Mar 12;

CBP y SRF co-regulan el crecimiento dendrítico y la maduración sináptica

Cell Death & Diff.
Publicado: 8 Marzo 2019

Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells

J Cell Biol.
Published: 2019 Feb 26;

The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels

J Neurosci. 39(6):949-969
Publicado: 6 Feb 2019

Silent Learning

Curr Biol. 28(21):3508-3515.e5.
Published: 2018 Nov 5;

Evolution of cortical neurogenesis in amniotes controlled by Robo signaling levels.

Cell 174, 1-17
Publicado: 28 Junio 2018

Increased Grik4 Gene Dosage Causes Imbalanced Circuit Output and Human Disease-Related Behaviors

Cell Rep. 23(13):3827-3838
Published: 2018 Jun 26;

Finding influential nodes for integration in brain networks using optimal percolation theory.

Nature Communications,
Publicado: 12 Junio 2018

PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation

Cell Reports, 22(10): 2541–2549
Published 6 March 2018

Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells.

Journal of Cell Biology,
Publicado: 22 Febrero 2018

Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons.

Cell Reports,
Publicado: 3 Octubre 2017

A right-handed signalling pathway drives heart looping in vertebrates.

Nature , 549: 86-90
Published: Sept 6 , 2017

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1.

Mol Neurobiol.
Published: 2017 Aug 16

Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia.

Development, 144(14): 2570-2583
Publicado: 15 Julio 2017

A Complex Code of Extrinsic Influences on Cortical Progenitor Cells of Higher Mammals.

Cerebral Cortex
Publicado: 6 Julio 2017

C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease.

Scientific Reports 7: 2477
Publicado: 30 Mayo 2017

Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.

Cell 169: 621-635
Publicado: 4 May 2017

Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects

eLife 2017;6:e21735
Publicado: 28 Marzo 2017

Distribuci�n dispersa de la selectividad para las propiedades cinem�ticas de los est�mulos en la corteza de barriles de rat�n.

Cereb Cortex 1-8.
Publicado: 25 Febrero 2017

Prenatal thalamic waves regulate cortical area size before sensory processing.

Nature Communications 8, Article number: 14172
Publicado: 3 Febrero 2017

The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells

Cell Reports , Volume 17, Issue 12, Pag 3153�3164
Published: 20 Dec. 2016

The speed�curvature power law in Drosophila larval locomotion.

Biology Letters 12:20160597
Publicado: 25 Octubre 2016

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer�s disease

Molecular Neurodegeneration 2016, 11:66
Published: 29 September 2016

Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes

Cerebral Cortex.
Publicado online: 20 Septiembre 2016

Captivating New Roles of F-Actin Cortex in Exocytosis and Bulk Endocytosis in Neurosecretory Cells

Trends in Neurosciences 39, 605-613
Sept. 2016

The �-amyloid peptide compromises Reelin signaling in Alzheimer�s disease

Scientific Reports 6, Article number: 31646
Published 17 agosto 2016.

A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels

Nature Communications (2016) 7, Article number: 11812
First published online: 6 Jun 2016

Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice

Nature Communications 7, Article number: 11761
Published 01 June 2016

Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells

Cereb Cortex (2016)
First published online: May 13, 2016

The Hippo Pathway Core Cassette Regulates Asymmetric Cell Division

Current Biology 25, 1�12
November 2, 2015

Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features

J Neurosci. 2015 Oct 7;35(40):13619-28.
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A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3

Science DOI: 10.1126/science.aac6767; Online October 1 2015

Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain

Nat Commun. 2015 Aug 27; 6:8095

Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain

The Journal of Neuroscience, 12 August 2015, 35(32): 11266-11280

Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch.

EMBO J.;34(15):2025-41 ; 2015 Aug 4

Snail1-induces partial epitelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease.

Nature Medicine. Aug 3, 2015. doi: 10.1038/nm.3901

Endocrine remodelling of the adult intestine sustains reproduction in Drosophila

Elife. Jul 28, 2015.

DCC receptor functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity

EMBO Reports (2015) embr.201439882

A Proteomic Analysis Reveals the Interaction of GluK1 Ionotropic Kainate Receptor Subunits with Go Proteins

The Journal of Neuroscience, 1 April 2015, 35(13): 5171-5179;

Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly

EMBO J. 2015 Apr 26. pii: e201591176.

Widespread vestibular activation of the rodent cortex

The Journal of Neuroscience 2015 Apr 15;35(15):5926-34

Frequency-dependent gating of hippocampal-neocortical interactions

Cerebral Cortex, 2015, March 10 ;

Heteromers of amyloid precursor protein in cerebrospinal fluid.

Molecular Neurodegeneration 2015, 10:2

Phenotyping the central nervous system of the embryonic mouse by magnetic resonance microscopy.

Cell Reports (2014) September 4.

Loss of neuronal 3D chromatin organization causes transcriptional and behavioral deficits related to serotonergic dysfunction.

Nat Comm. (2014) Jul 18;5:4450

Phenotyping the central nervous system of the embryonic mouse by magnetic resonance microscopy.

Neuroimage (2014),online 22 April 2014.

FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons

Current Biology, 24: 1-15, 20 Feb 2014

Statistical Wiring of Thalamic Receptive Fields Optimizes Spatial Sampling of the Retinal Image.

Neuron, 81(4): 943-956, 19 Feb 2014

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Nature Communications, 2014 January 20.

The synaptic connections delivering sensory information to neurons of the cerebral cortex provide a rich variety of messages.

The Journal of Neuroscience, 8 January 2014, 34(2): 515-526

Zic2-Dependent Axon Midline Avoidance Controls the Formation of Major Ipsilateral Tracts in the CNS.

Neuron 80(6): 1392-1406 , 2013 Dec 18

Uncoupling of EphA/ephrinA signaling and spontaneous activity in neural circuit wiring.

The Journal of Neuroscience, 13 November 2013, 33(46):18208-18218

A Serrate�Notch�Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development.

Journal of Cell Science 126: 4873-4884 , 2013 Nov 1

Conserved miR-8/miR-200 Defines a Glial Niche that Controls Neuroepithelial Expansion and Neuroblast Transition

Developmental Cell 27(2):174-187 ,2013 oct 28

eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aatRNA complex.
Cell Rep. 2013 oct 25, doi:10.1016/j.celrep.2013.09.030

Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes

Neuron 79, 1152-1168, september 18, 2013

Lineage-specific laminar organization of cortical GABAergic interneurons
Nature Neuroscience 2013, 16:1199-1210

Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition.
Nucl. Acids Res. first published online July 1, 2013.1-13 doi:10.1093/nar/gkt590

Genomic landscape of transcriptional and epigenetic dysregulation in a model of early-onset polyglutamine disease
The Journal of Neuroscience, June 19 (2013), 33(25):10471-10482

Regulation of cerebral cortex size and folding by expansion of basal progenitors
EMBO J (2013) http://dx.doi.org/10.1038/emboj.2013.96

Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate
Cell (2013), 153:535-549.

Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
Neuron(2013), 77: 457�471

Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.
Cancer Cell (2012), http://dx.doi.org/10.1016/j.ccr.2012.10.012

Slit/Robo Signaling Modulates the Proliferation of Central Nervous System Progenitors.

Neuron(2012), http://dx.doi.org/10.1016/j.neuron.2012.08.003

Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth
Development2012 Sept; 139(17):3200-10
doi:10.1242/dev.080564

The Actin-Binding Protein Canoe/AF-6 Forms a Complex with Robo and Is Required for Slit-Robo Signaling during Axon Pathfinding at the CNS Midline
The Journal of Neuroscience 2012 18 July; 32(39):10035-10044

Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth
Nat Neurosci. 2012 Jul 8. doci: 10.1038/nn.3160.

Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation
Science. 4 May 2012: Vol. 336 no. 6081 pp. 579-582.

The Lhx2 Transcription Factor Controls Thalamocortical Axonal Guidance by Specific Regulation of Robo1 and Robo2 Receptors
The Journal of Neuroscience, March 28, 2012. 32(13):4372–4385

cAMP Response Element-Binding Protein Is a Primary Hub of Activity-Driven Neuronal Gene Expression
The Journal of Neuroscience, December 14, 2011 � 31(50): 18237-50

A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area.
J Neurosci 31:16570-16580. 16 Nov 2011

The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation
The Journal of Cell Biology 195:553-562. doi:10.1083/jcb.201108112 (2011) (The Rockefeller University Press)

Germinal Zones in the Developing Cerebral Cortex of Ferret: Ontogeny, Cell Cycle Kinetics, and Diversity of Progenitors
Cerebral Cortex, 10 October 2011; doi:10.1093/cercor/bhq284

Emergent Growth Cone Responses to Combinations of Slit1 and Netrin 1 in Thalamocortical Axon Topography.
Current Biology 25, 1-8 (2011)

Reciprocal repression between Sox3 and Snail transcription factors defines embryonic territories at gastrulation.
Dev. Cell. 21, 546-558

Focal Adhesion Kinase Modulates Radial Glia-Dependent Neuronal Migration through Connexin-26.
J. Neurosci. 31, 11678-91 (2011).

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.
EMBO J., 2011. Aug 16. 30(20):4287-98