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People About the institute Javier Sáez Valero
Licenciatura:
 Degree in Biology, Faculty of Biology, University of Murcia, Spain, 1990.


Doctorado:
Ph.D. in Biology , at the Dept. of Biochemistry and Molecular Biology, University of Murcia, 1996.


Estancias Postdoctorales:
-Dept. of Pathology, Lab. of Molecular Neurobiology, Melbourne Univ., VIC, Australia (1996-1999)
-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italia (1999)


Estancias Anteriores:
-Research scientist at the IN-UMH/CSIC supported by a MEC return grant (2000)
-Research scientist at the Hosp. Gral. Univ. Alicante supported by a FIS grant (SNS-ISC-III) (2001)
 


Situación Actual:
Catedrático, Dpto. Bioquímica y Biología Molecular, Universidad Miguel Hernández de Elche.


Líneas de Investigación:
1. Relationship between Aβ and presenilin-1 with acetylcholinesterase
2. Reelin in Alzheimer’s disease: Aβ and P-tau cross-talk, a role for Reelin?
3. New Alzheimer’s diagnostic biomarkers:
         3.1. Glycoforms of proteins
         3.2. Aβ related proteins


Publicaciones Relevantes:

Sogorb-Esteve A , García-Ayllón MS, Fortea J, Sánchez-Valle R, Lleó A, Molinuevo JL, Sáez-Valero J. " Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease. " Mol Neurodegener . 11 , - 66 ( 2016 )

Garcia-Ayllón MS. , Cauli O, Silveyra MX, Rodrigo R, Candela A, Compañ A, Jover R, Pérez-Mateo M, Martínez S, Felipo V, Sáez-Valero J. " Brain cholinergic impairment in liver failure. " Brain . 131 , 2946 - 2956 ( 2008 )

Botella-Lopez A. , Burgaya, F; Gavin, R; Garcia-Ayllon, MS; Gomez-Tortosa, E; Peña-Casanova, J; Ureña, JM; Del Rio, JA; Blesa, R; Soriano, E; Saez-Valero, J. " Reelin expression and glycosylation patterns are altered in Alzheimer's disease. " Proc Natl Acad Sci USA . 103 , 5573 - 5578 ( 2006 )

Garcia-Ayllon MS. , Silveyra MX.,Candela A.,Compañ A.,Claria J.,Jover R.,Perez-Mateo M.,Felipo V.,Martinez S.,Galceran J.,Saez-Valero J. " Changes in liver and plasma acetylcholinesterase of rats with bile duct ligation. " Hepatology . 43 , 444 - 453 ( 2006 )

Sáez-Valero J. , Sberna G., McLean C.A., Masters C.L., Small D.H. " Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer’s disease. " The Lancet . 350 , 929 - 929 ( 1997 )
CSIC-UMH
 
 
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Universidad Miguel Hernández

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