A synaptic protein complex determines the type of memories that our brains store

eLife 10:e71575 3
Published:Nov 17, 2021

The apolipoprotein receptor LRP3 compromises APP levels.

Alzheimers Res Ther. 13(1):181
Published: 2021 Nov 2

Body-fat sensor triggers ribosome maturation in the steroidogenic gland to initiate sexual maturation in Drosophila

Cell Reports, 37 3
Published: 12 October 2021

Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis.

Cell Rep. 35(10):10922
Published: 2021 Jun 8

Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming

Sci Adv (15):eabe8978 3
Published: 2021 April 7;

Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum

Elife 10:e60580
Published: 2021 Feb 18

Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea.

The Journal of Neuroscience 40:8976-8993
Published: 2020 Nov 18;

A Zic2-regulated switch in a noncanonical Wnt/Beta-catenin pathway is essential for the formation of bilateral circuits

Sci. Adv. 6(46):eaaz8797
Published: 2020 Nov 13

Repression of Irs2 by let‐7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium.

EMBO J 2020; e105479
Published: 29 Sept 2020;

Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks.

Elife. 2020; 9:e57313.
Published: 2020 Jul 20

Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain.

Science Advances Vol. 6, no. 26, eaba0154
Published: 24 jun 2020;

KAT3-dependent acetylation maintains neuronal identity in the adult mouse brain.

Nature Communications 11(1):2588
Published: 2020 May 22;

A gene regulatory network to control EMT programs in development and disease

Nature Communications.
10, Article number: 5115 (2019)
Published: 11 Nov 2019;

Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model.

Nature Communications
Published: 01 Nov 2019;

Spanish researchers discover how left-right information is integrated to ensure correct organ positioning.

Developmental Cell.
https://doi.org/10.1016/j.devcel.2019.09.012
Published: 17 October 2019;

Researchers at the CSIC-UMH Neuroscience Institute discover molecules in unicellular organisms that are crucial for the organization of vertebrate tissues

Molecular Biology and Evolution,
Published: 07 October 2019;

Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus.

Nat Neurosci.
Published: 09 September 2019;

Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb

Cell Reports 28 (10), 2715–2727.e5
Published: 3 September 2019;

Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.

eLife.
Published: 2019 May 15;

Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice

Science, Published: 2019 May 2;
N. Antón-Bolaños et al.,Science 10.1126/science.aav7617 (2019)

Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence.

JAMA Psychiatry
Published: 2019 Apr 3

A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves.

Current Biology
Published: 2019 Mar 12;

CBP and SRF co-regulate dendritic growth and synaptic maturation

Cell Death & Diff.
Published: March 8th, 2019

Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells

J Cell Biol.
Published: 2019 Feb 26;

The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels

J Neurosci. 39(6):949-969
Published: 2019 Feb 6

Silent Learning

Curr Biol. 28(21):3508-3515.e5.
Published: 2018 Nov 5;

Evolution of cortical neurogenesis in amniotes controlled by Robo signaling levels

Cell 174, 1-17
Published: June 28, 2018

Increased Grik4 Gene Dosage Causes Imbalanced Circuit Output and Human Disease-Related Behaviors

Cell Rep. 23(13):3827-3838
Published: 2018 Jun 26;

Finding influential nodes for integration in brain networks using optimal percolation theory.

Nature Communications
Published: June 12, 2018

PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation

Cell Reports, 22(10) Pages 2541–2549
Published: 6 March 2018

Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells.

Journal of Cell Biology,
Published: February 22, 2018

Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons

Cell Reports, 21: p47–59,
Published: October 03, 2017

A right-handed signalling pathway drives heart looping in vertebrates.

Nature , 549: 86-90
Published: Sept 6 , 2017

Inhibition of γ-secretase leads to an increase in presenilin-1.

Mol Neurobiol.
Published: 2017 Aug 16.

Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia.

Development , 144(14): 2570-2583
Published: July 15, 2017

A Complex Code of Extrinsic Influences on Cortical Progenitor Cells of Higher Mammals.

Cerebral Cortex
Published: July 6 , 2017

C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease.

Scientific Reports 7: 2477
Published 30 May 2017

Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.

Cell 169:621-635
Published: May 4 , 2017

Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects.

eLife 2017;6:e21735
Published 28 March 2017

Interspersed Distribution of Selectivity to Kinematic Stimulus Features in Supragranular Layers of Mouse Barrel Cortex.

Cereb Cortex 1-8
Published: 25 February 2017

Prenatal thalamic waves regulate cortical area size before sensory processing.

Nature Communications 8, Article number: 14172
Published 03 February 2017

The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells

Cell Reports, Volume 17, Issue 12, Pag 3153–3164
Published: 20 Dec 2016

The speed-curvature power law in Drosophila larval locomotion.

Biology Letters, 12:20160597
Published 25 October 2016.

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer’s disease.

Molecular Neurodegeneration 2016, 11:66
Published: 29 September 2016

Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes.

Cerebral Cortex.
First published online: September 20, 2016

Captivating New Roles of F-Actin Cortex in Exocytosis and Bulk Endocytosis in Neurosecretory Cells

Trends in Neurosciences 39, 605-613
Published 3 September 2016

The ß-amyloid peptide compromises Reelin signaling in Alzheimer’s disease

Scientific Reports 6, Article number: 31646
Published 17 August 2016

A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels

Nature Communications (2016) 7, Article number: 11812
First published online: 6 Jun 2016

Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice

Nature Communications 7, Article number: 11761
Published 01 June 2016

Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells

Cereb. Cortex (2016)
First published online: May 13, 2016

The Hippo Pathway Core Cassette Regulates Asymmetric Cell Division

Current Biology 25, 1–12
November 2, 2015

Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features

J Neurosci. 2015 Oct 7;35(40):13619-28.
doi: 10.1523/JNEUROSCI.2217-15.2015.

A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3

Science DOI: 10.1126/science.aac6767 ; Oct 1 2015

Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain

Nat Commun. 2015 Aug 27; 6:8095

Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain

The Journal of Neuroscience, 12 August 2015, 35(32): 11266-11280;

Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch.

EMBO J.;34(15):2025-41; 2015 Aug 4

Snail1-induces partial epitelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

Nature Medicine. Aug 3, 2015. doi: 10.1038/nm.3901

Endocrine remodelling of the adult intestine sustains reproduction in Drosophila.

Elife. Jul 28, 2015.

DCC receptor functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity

EMBO Reports (2015) embr.201439882

A Proteomic Analysis Reveals the Interaction of GluK1 Ionotropic Kainate Receptor Subunits with Go Proteins

The Journal of Neuroscience, 1 April 2015, 35(13): 5171-5179;

Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly

EMBO J. 2015 Apr 26. pii: e201591176.

Widespread vestibular activation of the rodent cortex

The Journal of Neuroscience 2015 Apr 15;35(15):5926-34

Frequency-dependent gating of hippocampal-neocortical interactions

Cerebral Cortex (2015), March 10.

Heteromers of amyloid precursor protein in cerebrospinal fluid.

Molecular Neurodegeneration 2015, 10:2

Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

Cell Reports (2014), September 4.

Loss of neuronal 3D chromatin organization causes transcriptional and behavioral deficits related to serotonergic dysfunction.

Nat Comm. (2014) Jul 18;5:4450

Phenotyping the central nervous system of the embryonic mouse by magnetic resonance microscopy.

Neuroimage (2014), online 22 April 2014

FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons

Current Biology, 24: 1-15, 20 Feb 2014

Statistical Wiring of Thalamic Receptive Fields Optimizes Spatial Sampling of the Retinal Image.

Neuron, 81(4): 943-956, 19 Feb 2014

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Nature Communications, 2014 January 20.

The synaptic connections delivering sensory information to neurons of the cerebral cortex provide a rich variety of messages.

The Journal of Neuroscience, 8 January 2014, 34(2): 515-526

Zic2-Dependent Axon Midline Avoidance Controls the Formation of Major Ipsilateral Tracts in the CNS.

Neuron 80(6): 1392-1406 , 2013 Dec 18.

Uncoupling of EphA/ephrinA signaling and spontaneous activity in neural circuit wiring.

The Journal of Neuroscience, 13 November 2013, 33(46):18208-18218

A Serrate–Notch–Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development.

Journal of Cell Science 126: 4873-4884 , 2013 Nov 1

Conserved miR-8/miR-200 Defines a Glial Niche that Controls Neuroepithelial Expansion and Neuroblast Transition

Developmental Cell 27(2):174-187 ,2013 oct 28

eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aatRNA complex.

Cell Rep. 2013 oct 25,doi:10.1016/j.celrep.2013.09.030

Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes

Neuron 79, 1152-1168, september 18, 2013

Lineage-specific laminar organization of cortical GABAergic interneurons

Nature Neuroscience 2013, 16:1199-1210

Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition.
Nucl. Acids Res. first published online July 1, 2013.1-13 doi:10.1093/nar/gkt590

Genomic landscape of transcriptional and epigenetic dysregulation in a model of early-onset polyglutamine disease

The Journal of Neuroscience, June 19 (2013), 33(25):10471-10482

Regulation of cerebral cortex size and folding by expansion of basal progenitors
EMBO J (2013) http://dx.doi.org/10.1038/emboj.2013.96

Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate
Cell (2013), 153:535-549.

Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
Neuron(2013), 77: 457–471

Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.
Cancer Cell (2012), http://dx.doi.org/10.1016/j.ccr.2012.10.012

Slit/Robo Signaling Modulates the Proliferation of Central Nervous System Progenitors.

Neuron(2012), http://dx.doi.org/10.1016/j.neuron.2012.08.003

Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth
Development 2012 Sept; 139(17):3200-10
doi:10.1242/dev.080564

The Actin-Binding Protein Canoe/AF-6 Forms a Complex with Robo and Is Required for Slit-Robo Signaling during Axon Pathfinding at the CNS Midline
The Journal of Neuroscience 2012 Jul 18; 32(39): 10035-10044

Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth
Nat Neurosci. 2012 Jul 8. doci: 10.1038/nn.3160.

Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation
Science. 4 May 2012: Vol. 336 no. 6081 pp. 579-582.

The Lhx2 Transcription Factor Controls Thalamocortical Axonal Guidance by Specific Regulation of Robo1 and Robo2 Receptors
The Journal of Neuroscience, March 28, 2012. 32(13):4372–4385

cAMP Response Element-Binding Protein Is a Primary Hub of Activity-Driven Neuronal Gene Expression
The Journal of Neuroscience, December 14, 2011 • 31(50): 18237-50

A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area.
J Neurosci 31:16570-16580. 16 Nov 2011

The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation
The Journal of Cell Biology 195:553-562. doi:10.1083/jcb.201108112 (2011) (The Rockefeller University Press)

Germinal Zones in the Developing Cerebral Cortex of Ferret: Ontogeny, Cell Cycle Kinetics, and Diversity of Progenitors
Cerebral Cortex, 10 October 2011; doi:10.1093/cercor/bhq284

Emergent Growth Cone Responses to Combinations of Slit1 and Netrin 1 in Thalamocortical Axon Topography.
Current Biology 25, 1-8 (2011)

Reciprocal repression between Sox3 and Snail transcription factors defines embryonic territories at gastrulation.
Dev. Cell. 21, 546-558

Focal Adhesion Kinase Modulates Radial Glia-Dependent Neuronal Migration through Connexin-26.
J. Neurosci. 31, 11678-91 (2011).

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.
EMBO J., 2011. Aug 16. 30(20):4287-98