HomeAbout the InstituteResearch UnitsPeopleLinksPh.D ProgramEnglish Language Idioma EspañolWeb SearchIntranet Access
Research highlights About the institute
Spontaneous activity controls DCC receptor expression

DCC receptor functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity

EMBO Reports (2015) embr.201439882, Published online 06.05.2015

Mar Castillo-Paterna, Verónica Moreno-Juan, Anton Filipchuk, Luis Rodríguez-Malmierca, Rafael Susín, and Guillermina López-Bendito

Controlling axon growth rate is a fundamental process when establishing brain connections. Using the thalamocortical system as a model, we previously showed that spontaneous calcium activity controls the growth rate of thalamocortical axons by regulating the transcription of Robo1 through an NF-kB binding site in its promoter. Robo1 acts as a brake for thalamocortical axons growth in vivo. Here, we have identified the Netrin-1 receptor DCC acting as an accelerator for thalamic axon growth. Dcc transcription is regulated by spontaneous calcium activity in thalamocortical neurons. Activating DCC signaling restores normal axon growth in electrically silenced neurons. Moreover, we have identified an AP-1 binding site in the Dcc promoter that is crucial for the activity-dependent regulation of this gene. In sum, we have determined Dcc gene as a novel downstream target of spontaneous calcium activity involved in axon growth control. Together with our previously published data, we demonstrate a mechanism for axon growth control that relies on the activity-dependent regulation of two functionally opposed molecules, Robo1 and DCC. Their activity will allow a tight and efficient regulation of this process necessary for the correct establishment of neuronal connections during development.


Research Highlights Archive

Consejo Superior de Investigaciones Científicas
Universidad Miguel Hernández

Campus de San Juan | Sant Joan d’Alacant
Alicante | España

Tel. + 34 965 23 37 00
Fax + 34 965 91 95 61
© 2004-2020 Instituto de Neurociencias
Alicante | España | Legal Note |
Diseño web Digital Nature