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People About the institute Guillermina López Bendito
Biology studies, Universidad de Alicante, Spain. June 1997.

Ph.D program:
Doctorate in Neuroscience at the Instituto de Neurociencias, Universidad Miguel Hernández, Alicante, Spain, December 2000.

Posdoctoral Positions:
Postdoctoral Research Fellow at the Department of Human Anatomy & Genetics, Oxford (United Kingdom) from 2001-2004

Previous positions:
PhD student at the Department of Histology, Institute of Neuroscience, CSIC-Universidad Miguel Hernández in Alicante (Spain) from 1997-1999.

PhD student at the Developmental Neurobiology Unit, Institute of Neurosciences, CSIC Universidad Miguel Hernández in Alicante (Spain) from 1999-2000.

 “Ramón y Cajal” Research Scientist from Consejo Superior de Investigaciones Científicas since 1st of April 2004 - August 2007.

Current Position:
CSIC Group Leader

Research Fields:
Our research focuses to understand the cellular and molecular mechanisms involved in the guidance of the main axonal tracts of the CNS in mammals. In particular, we are interested in elucidating how one of the most complex axon guidance systems in the mammalian forebrain, the thalamocortical projection, develops. Thalamocortical axons translate sensory information to the cerebral cortex in a topographical manner. Furthermore, recent studies have suggested that an abnormal development of this projection might be involved in some neurological diseases such as autism or epilepsy.

We are interested in the study of two basic mechanisms required for normal development of the thalamocortical projection: (1) neuronal specification of thalamic neurons, the process by which different types of dorsal thalamic cells (visual, auditory…) are generated, and (2) topographical axon guidance and targeting to the cortex, which allows the integration of these thalamocortical projections into the cortical circuit. To study these mechanisms, we combine experimental embryology, imaging techniques and standard histology, cellular and molecular biology methods, using the mice as experimental model.

Representative Publications

Lopez-Bendito G. , Flames N.,Ma L.,Fouquet C.,Di Meglio T.,Chedotal A., Tessier-Lavigne M.,Marin O. " Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. " J Neurosci. . 27 , 3395 - 3407 ( 2007 )

Lopez-Bendito G.* , Cautinat A*, Sánchez JA, Bielle F, Flames N, Garratt AN, Talmage DA, Role L, Charnay P, Marín O, Garel S. " Tangential neuronal migration controls axon guidance: a role for Neuregulin-1 on thalamocortical axon navigation. " Cell . 125 , 127 - 142 ( 2006 ) * Co-author

López-Bendito, G. , Molnar, Z. " Thalamocortical development: How we are going to get there? " Nat Rev Neurosci . 4 , 276 - 289 ( 2003 )

Molnár, Z*. , López-Bendito, G*. Small, J. Partridge, L.D. Blakemore, C. Wilson, M.C. " Normal development of embryonic thalamocortical connectivity in the absence of evoked synaptic activity. " J Neurosci . 22(23) , 10313 - 10323 ( 2002 ) * Co-author

Jones, L* , López-Bendito, G*, Grüss, P. Stroykova, A., Molnár, Z. " Pax6 is required for the normal development of the forebrain axonal connections. " Development . 129(21) , 5041 - 5052 ( 2002 ) * Co-author
Consejo Superior de Investigaciones Científicas
Universidad Miguel Hernández

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