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People About the institute Manuel Criado Herrero
· Master Degree in Sciences, Biochemistry Specialty (1971-1976) Universidad Complutense of Madrid. Degree 2-2-1977

Ph.D program:
· Doctorate (1976-1980) Doctor in  Chemistry Universidad Complutense of Madrid. Doctor Degree 3-7-1980. Ph.D. Thesis made at  Instituto Cajal-C.S.I.C., Madrid (Dr. Jaime Monreal Llop, director) and Instituto de Biología Celular of Buenos  Aires,   Argentina  (Dr. Eduardo De Robertis)

Posdoctoral Positions:
1980-82 Postdoctoral fellow of the Alexander von Humboldt Foundation,  Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
1982-83 Postdoctoral fellow of the Max Planck Society, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
1984 Research Associate, Salk Institute for Biological Studies, La Jolla, California, U.S.A.
1985  Ossermann-McClure fellow of the Miasthenia Gravis Foundation, Salk Institute for Biological Studies, La Jolla, California, U.S.A.

Previous positions:
1986-89 Independent researcher of the Max Planck Society, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
1989-1994 Professor, Department of Neurochemistry, University of Alicante, Spain.
1994-1997 Full Professor, Department of Neurochemistry, University of Alicante
1997-present Full Professor, Department of Biochemistry and Molecular Biology, Universidad Miguel Hernández, San Juan-Alicante, Spain

Current Position:
Full Professor of Biochemistry and Molecular Biology

Research Fields:
The nicotinic acetylcholine receptor is widely distributed in the central and perypheral nervous systems. Important functions and pathologies specific of the nervous system, such as memory, anxiety, analgesy, cerebral circulation, nicotine adiction and Alzheimer disease, could have improved their understanding and/or treatment through the study of the mechanisms which regulate the function and expression of nicotinic receptors. We use cell and molecular biology techniques in the following main projects:
1. Mechanisms geverning the functional expression of nicotinic receptors. By using specific mutants we study subunit assembly and receptor gating.
2. Search for proteins able to regulate receptor biogenesis and function. Synthesis, assembly and localization of nicotinic receptors are complex processes that need the action of specific proteins. At present we characterize the interaction of some  proteins with specific nicotinic receptor subtypes.

Representative Publications

Castillo M. , Mulet, J., Aldea, M., Gerber, S., Sala, S., Sala, F., Criado, M. " Role of the N-terminal alpha-helix in biogenesis of alpha7 nicotinic receptors. " J. Neurochem . 108 , 1399 - 1409 ( 2009 )

Castelan F. , Castillo M,Mulet J, Sala S.,Sala F, Criado M. " Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression. " J.Neurochem . 105 , 617 - 627 ( 2008 )

Criado M. , M., Mulet, J., Castillo, M., Aldea, M., Sala, S., Sala, F. " Interactions between loop 5 and Beta-strand Beta6’ are involved in Alpha7 nicotinic acetylcholine receptors channel gating. " J.Neurochem . 104 , 719 - 730 ( 2008 )

Aldea M. , Mulet, J., Sala, S., Sala, F. Criado, M. " Non-charged amino acids from three different domains contribute to link agonist binding to channel gating in alpha7 nicotinic acetylcholine receptors. " J.Neurochem . 103 , 725 - 735 ( 2007 )

Castelan F. , Mulet J.,Aldea M.,Sala S.,Sala F.,Criado M. " Cytoplasmic regions adjacent to the M3 and M4 transmembrane segments influence expression and function of alpha7 nicotinic acetylcholine receptors. A study with single amino acid mutants. " J.Neurochem . 100 , 406 - 415 ( 2007 )
Consejo Superior de Investigaciones Científicas
Universidad Miguel Hernández

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