Publications per year

~ Team

~ Angel Barco


New publications

  • Cid E, Marquez-Galera A, Valero M, Gal B, Medeiros DC, Navarron CM, Ballesteros-Esteban L, Reig-Viader R, Morales AV, Fernandez-Lamo I, Gomez-Dominguez D, Sato M, Hayashi Y, Bayes A, Barco A, Lopez-Atalaya JP, de la Prida LM (2021). Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis. Cell Rep 35(10):109229. doi: 10.1016/j.celrep.2021.109229. .
  • Fuentes-Ramos M, Alaiz-Noya M, Barco A (2021). Transcriptome and epigenome analysis of engram cells: Next-generation sequencing technologies in memory research. Neurosci Biobehav Rev 127:865-875. doi: 10.1016/j.neubiorev.2021.06.010. .
  • Morenilla-Palau C, Lopez-Cascales MT, Lopez-Atalaya JP, Baeza D, Calvo-Diaz L, Barco A, Herrera E (2020). Repression of an alternative Wnt/beta-catenin pathway in axon-navigating neurons leads to the formation of bilateral circuits. Sci Adv 6(46):eaaz8797. doi: 10.1126/sciadv.aaz8797. .
  • Calzari L*, Barcella M*, Alari V, Braga D, Muñoz-Viana R, Barlassina C, Finelli P, Gervasini C, Barco A, Russo S, Larizza L (2020). Transcriptome analysis of iPSC-derived neurons from Rubinstein-Taybi patients reveals deficits in neuronal differentiation. Mol Neurobiol 57(9):3685-3701. doi: 10.1007/s12035-020-01983-6. .
  • Lipinski M, Muñoz-Viana R, del Blanco B, Marquez-Galera A, Medrano-Relinque J, Carames JM, Szczepankiewicz A, Fernandez-Albert J, Navarrón CM, Olivares R, Wilczynski GM, Canals S, Lopez-Atalaya JP and Barco A (2020). KAT3-dependent acetylation maintains neuronal identity in the adult mouse brain. Nat Comm. 11(1):2588. . Highlight:

Selected publications

  • Fernandez-Albert J, Lipinski M, Lopez-Cascales MT, Rowley MJ, Martin-Gonzalez AM, del Blanco B, Corces VG, Barco A (2019). Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus.Nat Neurosci. 22, 1718-30. . Highlight:

  • Scandaglia M, Lopez-Atalaya JP, Medrano-Fernandez A, Lopez-Cascales MT, del Blanco B, Lipinski M, Benito E, Olivares R, Iwase S, Shi Y, Barco A (2017). Loss of Kdm5c causes spurious transcription and prevents the fine-tuning of activity-regulated enhancers in neurons. Cell Reports 21(1):47-59. . Research highlight: HL-US

  • Lopez-Atalaya JP and Barco A (2014). Can changes in histone acetylation contribute to memory formation? Trends Genet Dec; 30(12):529-39.

  • Ito S, Magalska A, Alcaraz-Iborra M, Lopez-Atalaya JP, Rovira V, Contreras-Moreira B, Lipinski M, Olivares R, Martinez-Hernandez J, Ruszczycki B, Lujan R, Geijo-Barrientos E, Wilczynski GM and Barco A (2014). Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction. Nat Comm 2014 Jul 18;5:4450. . Research highlight: HL-US

  • Lopez-Atalaya JP, Ito S, Valor LM, Benito E and Barco A (2013). Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition. Nucleic Acids Res 41(17):8072-84. . Research highlight: HL-US

  • Lopez-Atalaya JP, Ciccarelli A, Viosca J, Valor LM, Jimenez-Minchan M, Canals S, Giustteto M and Barco A (2011). CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement. EMBO J 30(20): 4287-98. pubmed. Research highlight: HL-US

  • Benito E and Barco A (2010). CREB's control of intrinsic and synaptic plasticity: Implications for CREB-dependent memory models. Trends Neurosci 33(5):230-40. pubmed

  • Barco A, Patterson S, Alarcon JM, Gromova P, Mata-Roig, M, Morozov A and Kandel ER (2005). Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for both the maintenance of LTP and for synaptic capture. Neuron, 48(1): 123-137. pubmed

  • Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER and Barco A (2004). Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron 42(6):947-959. pubmed (Featured article pubmed)

  • Barco A, Alarcon JM and Kandel ER (2002) Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108(5):689-703. pubmed




Instituto de Neurociencias
Consejo Superior de Investigaciones Científicas (CSIC)
Universidad Miguel Hernández (UMH)

Av. Santiago Ramón y Cajal s/n
03550 San Juan de Alicante


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